scholarly journals Effect of pneumoperitoneum and Trendelenburg position on gastro-oesophageal reflux and lower oesophageal sphincter pressure

1996 ◽  
Vol 76 (1) ◽  
pp. 130-132 ◽  
Author(s):  
J P Tournadre ◽  
D Chassard ◽  
K R Berrada ◽  
P Bouletreau
Keyword(s):  
Lower Oesophageal Sphincter ◽  
Oesophageal Reflux ◽  
Sphincter Pressure ◽  
Trendelenburg Position ◽  
Lower Oesophageal Sphincter Pressure

scholarly journals Cisapride restores the decreased lower oesophageal sphincter pressure in reflux patients.

Gut ◽  
1988 ◽  
Vol 29 (5) ◽  
pp. 631-635 ◽  
Author(s):  
P Ceccatelli ◽  
J Janssens ◽  
G Vantrappen ◽  
S Cucchiara
Keyword(s):  
Lower Oesophageal Sphincter ◽  
Sphincter Pressure ◽  
Lower Oesophageal Sphincter Pressure

scholarly journals An ambulant porcine model of acid reflux used to evaluate endoscopic gastroplasty

Gut ◽  
1999 ◽  
Vol 44 (6) ◽  
pp. 782-788 ◽  
Author(s):  
S S Kadirkamanathan ◽  
E Yazaki ◽  
D F Evans ◽  
C C Hepworth ◽  
F Gong ◽  
...  
Keyword(s):  
Acid Reflux ◽  
Flexible Endoscopy ◽  
Lower Oesophageal Sphincter ◽  
Oesophageal Reflux ◽  
Antireflux Procedure ◽  
Sphincter Pressure ◽  
Large White ◽  
Oesophageal Wall ◽  
Therapeutic Procedures ◽  
Invasive Surgical Approach

BACKGROUNDThere is a lack of suitable models for testing of therapeutic procedures for gastro-oesophageal reflux disease. Endoscopic sewing methods might allow the development of a new less invasive surgical approach to treatment of gastrointestinal disorders.AIMSTo develop an animal model of gastro-oesophageal reflux for testing the efficacy of a new antireflux procedure, endoscopic gastroplasty, performed at flexible endoscopy without laparotomy or laparoscopy.METHODSAt endoscopy a pH sensitive radiotelemetry capsule was sewn to the oesophageal wall, 5 cm above the lower oesophageal sphincter, in six large white pigs. Ambulant pH recordings (48–96 hours; total 447 hours) were obtained. The median distal oesophageal pH was 6.8 (range 6.4–7.3); pH was less than 4 for 9.3% of the time. After one week, endoscopic gastroplasty was performed by placing sutures below the gastro-oesophageal junction, forming a neo-oesophagus of 1–2 cm in length. Postoperative manometry and pH recordings (24–96 hours; total 344 hours) were carried out.RESULTSFollowing gastroplasty, the median sphincter pressure increased significantly from 3 to 6 mm Hg and in length from 3 to 3.75 cm. The median time pH was less than 4 decreased significantly from 9.3% to 0.2%.CONCLUSIONSThese are the first long term measurements of oesophageal pH in ambulant pigs. The finding of spontaneous reflux suggested a model for studying treatments of reflux. Endoscopic gastroplasty increased sphincter pressure and length and decreased acid reflux.

Anaesthesia Induction and Lower Oesophageal Sphincter Pressure

1978 ◽  
Vol 22 (1) ◽  
pp. 16-20 ◽  
Author(s):  
S. Laitinen ◽  
R. E. M. Mokka ◽  
J. V. I. Valanne ◽  
T. K. I. Larmi
Keyword(s):  
Lower Oesophageal Sphincter ◽  
Sphincter Pressure ◽  
Anaesthesia Induction ◽  
Lower Oesophageal Sphincter Pressure
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