scholarly journals THE ANALGESIC ACTION AND NEURONAL MECHANISM OF PROPANIDID

1972 ◽  
Vol 44 (8) ◽  
pp. 809-816 ◽  
Author(s):  
TATSUSHI FUJITA ◽  
HlDEAKI ISHIKURA ◽  
YASUHARU KlTANI
Keyword(s):  
Analgesic Action ◽  
Neuronal Mechanism

Assessment for the Role of Serotonin Receptor Subtype 3 for the Analgesic Action of Morphine at the Spinal Level

2005 ◽  
Vol 18 (2) ◽  
pp. 113
Author(s):  
Myung Ha Yoon ◽  
Hong Buem Bae ◽  
Jeong Il Choi ◽  
Seok Jae Kim ◽  
Chang Mo Kim ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Receptor Subtype ◽  
Analgesic Action ◽  
Spinal Level ◽  
Subtype 3

Inhibition of Glutamatergic Synaptic Input to Spinal Lamina IIo Neurons by Presynaptic α2-Adrenergic Receptors

2002 ◽  
Vol 87 (4) ◽  
pp. 1938-1947 ◽  
Author(s):  
Yu-Zhen Pan ◽  
De-Pei Li ◽  
Hui-Lin Pan
Keyword(s):  
Receptor Antagonist ◽  
Synaptic Input ◽  
Adrenergic Receptors ◽  
Adrenergic Receptor ◽  
Dorsal Root ◽  
Primary Afferents ◽  
Noradrenergic System ◽  
Analgesic Action ◽  
Adrenergic Agonists ◽  
Excitatory Synaptic Input

Activation of spinal α2-adrenergic receptors by the descending noradrenergic system and α2-adrenergic agonists produces analgesia. However, the sites and mechanisms of the analgesic action of spinally administered α2-adrenergic receptor agonists such as clonidine are not fully known. The dorsal horn neurons in the outer zone of lamina II (lamina IIo) are important for processing nociceptive information from C-fiber primary afferents. In the present study, we tested a hypothesis that activation of presynaptic α2-adrenergic receptors by clonidine inhibits the excitatory synaptic input to lamina IIo neurons. Whole cell voltage-clamp recordings were performed on visualized lamina IIo neurons in the spinal cord slice of rats. The miniature excitatory postsynaptic currents (mEPSCs) were recorded in the presence of tetrodotoxin, bicuculline, and strychnine. The evoked EPSCs were obtained by electrical stimulation of the dorsal root entry zone or the attached dorsal root. Both mEPSCs and evoked EPSCs were abolished by application of 6-cyano-7-nitroquinoxaline-2,3-dione. Clonidine (10 μM) significantly decreased the frequency of mEPSCs from 5.8 ± 0.9 to 2.7 ± 0.6 Hz (means ± SE) without altering the amplitude and the decay time constant of mEPSCs in 25 of 27 lamina IIo neurons. Yohimbine (2 μM, an α2-adrenergic receptor antagonist), but not prazosin (2 μM, an α1-adrenergic receptor antagonist), blocked the inhibitory effect of clonidine on the mEPSCs. Clonidine (1–20 μM, n = 8) also significantly attenuated the peak amplitude of evoked EPSCs in a concentration-dependent manner. The effect of clonidine on evoked EPSCs was abolished in the presence of yohimbine ( n = 5). These data suggest that clonidine inhibits the excitatory synaptic input to lamina IIo neurons through activation of α2-adrenergic receptors located on the glutamatergic afferent terminals. Presynaptic inhibition of glutamate release from primary afferents onto lamina IIoneurons likely plays an important role in the analgesic action produced by activation of the descending noradrenergic system and α2-adrenergic agonists.

Non-neuronal regulation and repertoire of cholinergic receptors in organs

2010 ◽  
Vol 1 (5-6) ◽  
pp. 357-366
Author(s):  
Tsuyoshi Sato ◽  
Dai Chida ◽  
Takanori Iwata ◽  
Michihiko Usui ◽  
Kouki Hatori ◽  
...  
Keyword(s):  
Therapeutic Agents ◽  
Cholinergic Receptors ◽  
Target Cells ◽  
Neuronal Mechanism ◽  
Neuronal Regulation ◽  
Cholinergic Pathway

AbstractMany studies on the cholinergic pathway have indicated that cholinergic receptors, which are widely expressed in various cells, play an important role in all body organs. In this review, we present the concept that cholinergic responses are regulated through a neuronal or non-neuronal mechanism. The neuronal mechanism is a system in which acetylcholine binds to cholinergic receptors on target cells through the nerves. In the non-neuronal mechanism, acetylcholine, produced by neighboring cells in an autocrine/paracrine manner, binds to cholinergic receptors on target cells. Both mechanisms subsequently lead to physiological and pathophysiological responses. We also investigated the subunits/subtypes of cholinergic receptors on target cells, physiological and pathophysiological responses of the organs via cholinergic receptors, and extracellular factors that alter the subtypes/subunits of cholinergic receptors. Collectively, this concept will elucidate how cholinergic responses occur and will help us conduct further experiments to develop new therapeutic agents.

scholarly journals Analgesic action of nicotine on tibial nerve transection (TNT)-induced mechanical allodynia through enhancement of the glycinergic inhibitory system in spinal cord

Life Sciences ◽  
2006 ◽  
Vol 80 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Md. Joynal Abdin ◽  
Norimitsu Morioka ◽  
Katsuya Morita ◽  
Tomoya Kitayama ◽  
Shigeo Kitayama ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mechanical Allodynia ◽  
Tibial Nerve ◽  
Nerve Transection ◽  
Analgesic Action ◽  
Inhibitory System

scholarly journals Neuronal mechanism of nociceptin-induced modulation of learning and memory: Involvement of N-methyl-D-aspartate receptors

2003 ◽  
Vol 8 (8) ◽  
pp. 752-765 ◽  
Author(s):  
T Mamiya ◽  
K Yamada ◽  
Y Miyamoto ◽  
N König ◽  
Y Watanabe ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Neuronal Mechanism

Charles and Emma Darwin: Under the ‘influence’ of chloroform anaesthesia

2021 ◽  
pp. 0310057X2110203
Author(s):  
John D Paull ◽  
Michael G Cooper
Keyword(s):  
Carnivorous Plants ◽  
Analgesic Action ◽  
Online Search ◽  
Cambridge University

A number of Charles Darwin’s biographies record the administration of chloroform by Darwin to his wife Emma, during her labour and delivery of her eighth child, Leonard. This occurred on 15 January 1850, a little over two years after James Young Simpson in Edinburgh described the analgesic action of inhaled chloroform. An online search of more than 9000 items of Darwin’s correspondence at Cambridge University and other sources revealed that he was an active proponent and user of chloroform in midwifery, for euthanising animals he studied, as well as in botanical studies of carnivorous plants. He also discovered that the concurrent inhalation of chloroform, during its administration to his wife, alleviated his distressing anxiety which he suffered when present at her earlier confinements.

scholarly journals A REVIEW OF ANALGESIC ACTION OF PATHADI YOG IN TREATMENT OF PILES

2015 ◽  
Vol 6 (1) ◽  
pp. 65-68
Author(s):  
Sandeep Kale ◽  
Anand Kalaskar ◽  
Vikram Supugade ◽  
Yogesh Narkhede ◽  
Pradip Kale
Keyword(s):  
Analgesic Action

Analgesic Action and Pharmacokinetics of Morphine and Diazepam in Man

1979 ◽  
Vol 51 (6) ◽  
pp. 495-502 ◽  
Author(s):  
J C Yang ◽  
W Crawford Clark ◽  
S H Ngai ◽  
Barry A. Berkowitz ◽  
Sydney Spector
Keyword(s):  
Analgesic Action

Caine: Evidence for cns analgesic action

Pain ◽  
1987 ◽  
Vol 30 ◽  
pp. S48 ◽  
Author(s):  
Yu Lin ◽  
T. J. Morrow ◽  
K. L. Casey
Keyword(s):  
Analgesic Action

Lack of Antinociceptive Activity of Sumatriptan in Rodents

Cephalalgia ◽  
1990 ◽  
Vol 10 (5) ◽  
pp. 207-212 ◽  
Author(s):  
Malcolm Skingle ◽  
Phillip J Birch ◽  
Glynnis E Leighton ◽  
Patrick PA Humphrey
Keyword(s):  
Antinociceptive Activity ◽  
The Novel ◽  
Analgesic Action ◽  
Beneficial Effects ◽  
Noxious Stimuli ◽  
Anti Migraine Drug

The present study attempts to determine whether the novel anti-migraine drug sumatriptan has antinociceptive activity in rodents. Sumatriptan had little or no antinociceptive activity against a range of noxious stimuli and we therefore conclude that it is unlikely that the beneficial effects of the drug in treating migraine are due to a non-specific analgesic action.

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