scholarly journals Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors

2008 ◽  
Vol 24 (17) ◽  
pp. 1850-1857 ◽  
Author(s):  
J. Liu ◽  
G. D. Stormo
Keyword(s):  
Transcription Factors ◽  
Zinc Finger ◽  
Dna Recognition ◽  
C2h2 Zinc Finger ◽  
Context Dependent ◽  
Recognition Code

scholarly journals Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

Science ◽  
2018 ◽  
Vol 362 (6414) ◽  
pp. eaat0572 ◽  
Author(s):  
Quinlan L. Sievers ◽  
Georg Petzold ◽  
Richard D. Bunker ◽  
Aline Renneville ◽  
Mikołaj Słabicki ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Small Molecules ◽  
Zinc Finger ◽  
Ubiquitin Ligase ◽  
Biochemical Analysis ◽  
Zinc Fingers ◽  
Functional Characterization ◽  
C2h2 Zinc Finger

The small molecules thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruiting a Cys2-His2 (C2H2) zinc finger domain to Cereblon (CRBN), the substrate receptor of the CRL4CRBN E3 ubiquitin ligase. We screened the human C2H2 zinc finger proteome for degradation in the presence of thalidomide analogs, identifying 11 zinc finger degrons. Structural and functional characterization of the C2H2 zinc finger degrons demonstrates how diverse zinc finger domains bind the permissive drug-CRBN interface. Computational zinc finger docking and biochemical analysis predict that more than 150 zinc fingers bind the drug-CRBN complex in vitro, and we show that selective zinc finger degradation can be achieved through compound modifications. Our results provide a rationale for therapeutically targeting transcription factors that were previously considered undruggable.

scholarly journals Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors

2009 ◽  
Vol 122 (9) ◽  
pp. 1452-1460 ◽  
Author(s):  
J.-M. Mingot ◽  
S. Vega ◽  
B. Maestro ◽  
J. M. Sanz ◽  
M. A. Nieto
Keyword(s):  
Transcription Factors ◽  
Zinc Finger ◽  
Nuclear Import ◽  
C2h2 Zinc Finger

DNA recognition code of transcription factors

1995 ◽  
Vol 8 (4) ◽  
pp. 319-328 ◽  
Author(s):  
Masashi Suzuki ◽  
Steven E. Brenner ◽  
Mark Gerstein ◽  
Naoto Yagi
Keyword(s):  
Transcription Factors ◽  
Dna Recognition ◽  
Recognition Code
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