scholarly journals Computational resources associating diseases with genotypes, phenotypes and exposures

2018 ◽  
Vol 20 (6) ◽  
pp. 2098-2115 ◽  
Author(s):  
Wenliang Zhang ◽  
Haiyue Zhang ◽  
Huan Yang ◽  
Miaoxin Li ◽  
Zhi Xie ◽  
...  
Keyword(s):  
Software Tools ◽  
Omics Data ◽  
Related Factors ◽  
Environment Factors ◽  
The Public ◽  
Chemical Exposures ◽  
Development History ◽  
The Past ◽  
History Of ◽  
Computational Resources

AbstractThe causes of a disease and its therapies are not only related to genotypes, but also associated with other factors, including phenotypes, environmental exposures, drugs and chemical molecules. Distinguishing disease-related factors from many neutral factors is critical as well as difficult. Over the past two decades, bioinformaticians have developed many computational resources to integrate the omics data and discover associations among these factors. However, researchers and clinicians are experiencing difficulties in choosing appropriate resources from hundreds of relevant databases and software tools. Here, in order to assist the researchers and clinicians, we systematically review the public computational resources of human diseases related to genotypes, phenotypes, environment factors, drugs and chemical exposures. We briefly describe the development history of these computational resources, followed by the details of the relevant databases and software tools. We finally conclude with a discussion of current challenges and future opportunities as well as prospects on this topic.

Reflections on the Public Interpretation of Regional Environmental History In Western Pennsylvania

2014 ◽  
Vol 36 (3) ◽  
pp. 50-69
Author(s):  
Chris J. Magoc
Keyword(s):  
Environmental History ◽  
Public History ◽  
Industrial Development ◽  
The Public ◽  
Public Interpretation ◽  
The Past ◽  
Natural Resource Extraction ◽  
History Of ◽  
Environmental Histories ◽  
Western Pennsylvania

This essay attempts to counter the scarcity of efforts to address issues of natural resource extraction and environmental exploitation in public history forums. Focused on western Pennsylvania, it argues that the history of industrial development and its deleterious environmental impacts demands a regional vision that not only frames these stories within the ideological and economic context of the past, but also challenges residents and visitors to consider this history in light of the related environmental concerns of our own time. The essay explores some of the difficult issues faced by public historians and practitioners as they seek to produce public environmental histories that do not elude opportunities to link past and present in meaningful ways.

Veronicas and Artists

2017 ◽  
Keyword(s):  
Contemporary Art ◽  
Religious Images ◽  
The Public ◽  
The Past ◽  
History Of Art ◽  
The Status ◽  
History Of ◽  
The Way ◽  
Contemporary Artists

Chapter One deals with several central issues with regard to understanding the role of religious motifs in contemporary art. Besides being a repetition of imagery from the past, religious motifs embedded in contemporary artworks become a means to problematise not only the way different periods in the history of art are delimited, but larger and seemingly more rigid distinctions as those between art and non-art images. Early religious images differ significantly from art images. The two types are regulated according to different sets of rules related to the conditions of their production, display, appreciation and the way images are invested with the status of being true or authentic instances of art or sacred images. Chapter One provides a discussion of the important motif of the image not made by an artist’s hand, or acheiropoietos, and its survival and transformation, including its traces in contemporary image-making practices. All images are the result of human making; they are fictions. The way the conditions of these fictions are negotiated, or the way the role of the maker is brought to visibility, or concealed, is a defining feature of the specific regime of representation. While the cult image concealed its maker in order to maintain its public significance, and the later art image celebrated the artist as a re-inventor of the old image, contemporary artists cite religious images in order to reflect on the very procedures that produce the public significance and status of images.

The development history of accident causation models in the past 100 years: 24Model, a more modern accident causation model

2020 ◽  
Vol 134 ◽  
pp. 47-82 ◽  
Author(s):  
Gui Fu ◽  
Xuecai Xie ◽  
Qingsong Jia ◽  
Zonghan Li ◽  
Ping Chen ◽  
...  
Keyword(s):  
Development History ◽  
The Past ◽  
Accident Causation ◽  
History Of

“Tanked up Yobs” and “Self-Pity City”. Deconstructing the Myths of the Hillsborough Disaster

STADION ◽  
2019 ◽  
Vol 43 (1) ◽  
pp. 58-75
Author(s):  
Alan McDougall
Keyword(s):  
Public Discourse ◽  
British History ◽  
Public Realm ◽  
Grassroots Activism ◽  
The Public ◽  
The Past ◽  
Overwhelming Evidence ◽  
History Of ◽  
The Media ◽  
Government Legislation

On 15 April 1989, Liverpool FC played Nottingham Forest in an FA Cup semi-final at the Hillsborough Stadium in Sheffield in northern England. Catastrophic errors by the police and other organisations led to the deaths of 96 Liverpool supporters, crushed against the perimeter fences on the Leppings Lane terrace. Though the horrific facts of the disaster were quickly and widely known, they were lost beneath another narrative, promoted by the police, numerous politicians, and large sections of the media. This narrative blamed the disaster on “tanked up yobs”: drunk and aggressive Liverpool supporters, who turned up late and forced their way into the ground. Over the subsequent years and decades, as Hillsborough campaigners vainly sought justice for the disaster’s victims in a series of trials and inquests, the destructive allegation remained in the public realm. It was reinforced by establishment dismissal of Liverpool as a “self-pity city”, home to a community incapable of accepting official verdicts or of leaving the past in the past. This essay uncovers the history of the myths of the Hillsborough disaster. It first shows how these myths were established - how false narratives, with powerful backers, shifted responsibility for the disaster from the police to supporters, despite overwhelming evidence to the contrary. It then examines how these myths were embedded in public discourse - how Liverpool was demonised as an aggressively sentimental city where people refused to admit to “killing their own”. It finally analyses how these myths were overturned through research, media mobilisation, and grassroots activism, a process that culminated in the 2016 inquest verdict, which ruled that the 96 Hillsborough victims were unlawfully killed. In doing so, the essay shows how Hillsborough became a key event in modern British history, influencing everything from stadium design to government legislation.

The Lost Lullaby and Other Stories about Being an Armenian in Turkey

2006 ◽  
Vol 34 ◽  
pp. 67-92 ◽  
Author(s):  
Melissa Bilal
Keyword(s):  
Public Sphere ◽  
Cultural Politics ◽  
Lived Experiences ◽  
The Public ◽  
The Past ◽  
Armenian Identity ◽  
History Of ◽  
The Public Sphere ◽  
Different Cultures

Nınçir mangig im sirasun, Oror yem asum, Baydzar lusinn e meğm hayum, Ko ororotsum.By analyzing the transmission of Armenian lullabies within the changing contexts of identity and cultural politics in Turkey, this paper addresses displacement and loss as two interrelated experiences shaping the sense of being an Armenian in Turkey. I criticize the liberal multiculturalist perspective that represents cultures in a way that cuts the link between the past and the present, by dissociating different cultures from the history of their presence in Anatolia and the destruction of that presence. I argue that in such a context where cultures are detached from lived experiences and memory, it becomes impossible to share the stories of violence and pain in the public sphere; hence, the loss itself becomes the experience of being Armenian. Finally, I try to explain how today young generations of Armenians in İstanbul, in their search for an Armenian identity, have developed a certain way of belonging to the space and culture, a way of belonging that is very much shaped by the experience of loss.

scholarly journals PERSEBARAN ARCA BERCORAK SIWAISTISDI KOTA DENPASAR, BALI

2017 ◽  
Vol 29 (2) ◽  
pp. 93
Author(s):  
I Wayan Sumerata ◽  
Dewa Gede Yadhu Basudewa
Keyword(s):  
Qualitative Analysis ◽  
Research Result ◽  
Religious Activities ◽  
Literature Study ◽  
Human Culture ◽  
Development History ◽  
The Past ◽  
Alteration Process ◽  
The People ◽  
History Of

This research aims to reconstruct the history of human culture, and the depiction of alteration process of man’s culture in the past as well as contribute data about development history of figurine art, particuarly figurine with siva characteristic in Denpasar. Data were collected using observation, interview, and literature study method and were analyzed using qualitative analysis and iconography. The research result shows that figurines with siva characteristic in Denpasar distributed in ten sanctuaries. The types of siva character figurine are Durga, Ganesha, linga yoni, linga, yoni, holy priest, and nandi. Up to now those figurines are still functioned by the people for religious activities and as media to connect with God Almighty. Penelitian ini bertujuan untuk merekonstruksi sejarah kebudayaan manusia masa lampau, dan penggambaran proses perubahan budaya manusia masa lampau, serta memberikan sumbangan data mengenai sejarah perkembangan seni arca, khususnya yang bercorak Siwaistis di Kota Denpasar. Pengumpulan data menggunakan metode observasi, wawancara, dan studi kepustakaan dan dianalisis menggunakan analisis kualitatif dan ikonografi. Hasil penelitian menunjukkan bahwa arca bercorak Siwaistis di Kota Denpasar tersebar pada 10 tempat suci. Jenis arca bercorak Siwaistis yang ditemukan seperti arca Dewi Durga, arca Ganesha, lingga yoni, lingga, yoni, arca pendeta, dan arca Nandi. Sampai saat ini arca-arca tersebut masih difungsikan dan dimanfaatkan untuk kegiatan keagamaan sekaligus sebagai media untuk menghubungkan diri kepada Tuhan Yang Maha Esa.

scholarly journals Kildesikring og kaoskontroll – om bevaringsideologier og forvaltningsstrategier i en digital tidsalder

1970 ◽  
pp. 102
Author(s):  
Wenche Brun ◽  
Kristine Orestad Sørgaard
Keyword(s):  
Critical Review ◽  
Storage Conditions ◽  
Management Systems ◽  
Collection Management ◽  
Public Attention ◽  
The Public ◽  
The Past ◽  
History Of ◽  
The Subject ◽  
Improve Access

Norwegian museums have been the subject of a great deal of public attention in recent years. Unfortunately, this is not because of their interesting, compelling and thought-provoking exhibitions, but because of poor preservation practices and deteriorating collections. Previous reports have highlighted numerous failings in the management of these collections. A large portion of the collections has suffered through decades of poor storage. Some objects have even been damaged as a result of unacceptable storage conditions. Proper management of the collections has been hampered still further by the lack of common management systems. In the past ten to fifteen years, several projects have been launched in order to enhance collection management and to make the collections more accessible to the public. In this paper, we give a brief outline of the history of collections. We also provide a critical review of the projects and offer some suggestions as to what museums can do to further improve access to and the preservation of collections. 

The Oxford Handbook of Music Listening in the 19th and 20th Centuries

2018 ◽  
Keyword(s):  
Case Studies ◽  
Historical Research ◽  
Public Realm ◽  
Music Listening ◽  
Historical Sources ◽  
The Public ◽  
The Past ◽  
Wide Range ◽  
Musical Cultures ◽  
History Of

This handbook takes on the task of examining the history of music listening over the past two hundred years. It uses the “art of listening” as a leitmotif encompassing an entanglement of interdependent practices and discourses about a learnable mode of perception. The art of listening first emerged around 1800 and was adopted and adapted across the public realm to suit a wide range of collective listening situations from popular to serious art forms up to the present day. Because this is a relatively new subject in historical research, the volume combines case studies from several disciplines in order to investigate whether, how, and why practices of music listening changed. Focusing on a diverse set of locations and actors and using a range of historical sources, it attempts to historicize and reconstruct the evolution of listening styles to show the wealth of variants in listening. In doing so, it challenges the inherited image of the silent listener as the dominant force in musical cultures.

scholarly journals An Integrative Approach to Assessing Diet–Cancer Relationships

Metabolites ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 123 ◽  
Author(s):  
Rachel Murphy
Keyword(s):  
Systems Biology ◽  
Health Professionals ◽  
Biomarker Discovery ◽  
Integrative Approach ◽  
Omics Data ◽  
The Public ◽  
The Past ◽  
Diet And Cancer ◽  
The Relationship ◽  
Considerable Body

The relationship between diet and cancer is often viewed with skepticism by the public and health professionals, despite a considerable body of evidence and general consistency in recommendations over the past decades. A systems biology approach which integrates ‘omics’ data including metabolomics, genetics, metagenomics, transcriptomics and proteomics holds promise for developing a better understanding of how diet affects cancer and for improving the assessment of diet through biomarker discovery thereby renewing confidence in diet–cancer links. This review discusses the application of multi-omics approaches to studies of diet and cancer. Considerations and challenges that need to be addressed to facilitate the investigation of diet–cancer relationships with multi-omic approaches are also discussed.

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