scholarly journals Corrigendum to: Systemic effects of missense mutations on SARS-CoV-2 spike glycoprotein stability and receptor-binding affinity

2021 ◽  
Author(s):  
Shaolei Teng ◽  
Adebiyi Sobitan ◽  
Raina Rhoades ◽  
Dongxiao Liu ◽  
Qiyi Tang
Keyword(s):  
Binding Affinity ◽  
Receptor Binding ◽  
Systemic Effects ◽  
Missense Mutations ◽  
Spike Glycoprotein ◽  
Receptor Binding Affinity

Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
MF Sprinzl ◽  
L Bührer ◽  
D Strand ◽  
G Schreiber ◽  
PR Galle ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Binding ◽  
Receptor Binding Affinity ◽  
Ifn Alpha ◽  
Antiviral Effects

[Aladan3]TIPP: A fluorescent ?-opioid antagonist with high ?-receptor binding affinity and ? selectivity

Biopolymers ◽  
2005 ◽  
Vol 80 (2-3) ◽  
pp. 325-331 ◽  
Author(s):  
Heru Chen ◽  
Nga N. Chung ◽  
Carole Lemieux ◽  
Bogumil Zelent ◽  
Jane M. Vanderkooi ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Binding ◽  
Opioid Antagonist ◽  
Receptor Binding Affinity

scholarly journals Additional disulfide bonds in insulin: Prediction, recombinant expression, receptor binding affinity, and stability

2015 ◽  
Vol 24 (5) ◽  
pp. 779-788 ◽  
Author(s):  
Tine N. Vinther ◽  
Ingrid Pettersson ◽  
Kasper Huus ◽  
Morten Schlein ◽  
Dorte B. Steensgaard ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Binding ◽  
Disulfide Bonds ◽  
Recombinant Expression ◽  
Receptor Binding Affinity

scholarly journals The expression of hACE2 receptor protein and its involvement in SARS-CoV-2 entry, pathogenesis, and its application as potential therapeutic target

Tumor Biology ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 177-196
Author(s):  
Lobna Al-Zaidan ◽  
Sarra Mestiri ◽  
Afsheen Raza ◽  
Maysaloun Merhi ◽  
Varghese Philipose Inchakalody ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Receptor Binding ◽  
Virus Disease ◽  
Respiratory Illness ◽  
Host Cells ◽  
World Health ◽  
Receptor Protein ◽  
Unknown Etiology ◽  
Spike Glycoprotein ◽  
Binding Interface

Pneumonia cases of unknown etiology in Wuhan, Hubei province, China were reported to the World Health Organization on 31st of December 2019. Later the pathogen was reported to be a novel coronavirus designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes Corona virus disease 2019 (COVID-19). The disease outspread was followed by WHO declaration of COVID-19 pandemic as a “Public Health Emergency of International Concern”. SARS-CoV-2 is a novel pathogenic beta coronavirus that infects humans causing severe respiratory illness. However, multifarious factors can contribute to the susceptibility to COVID-19 related morbidity and mortality such as age, gender, and underlying comorbidities. Infection initiates when viral particles bind to the host cell surface receptors where SARS-CoV-2 spike glycoprotein subunit 1 binds to the Angiotensin Converting Enzyme 2 (ACE2). It is of importance to mention that SARS-CoV and SARS-CoV-2 viruses’ mediate entry into the host cells via ACE2 receptor which might be correlated with the structural similarity of spike glycoprotein subunit 1 of both SARS viruses. However, the structural binding differs, whereas ACE2 receptor binding affinity with SARS-CoV-2 is 4 folds higher than that with SARS-CoV. Moreover, amino acids sequence divergence between the two S glycoproteins might be responsible for differential modulations of the specific immune response to both viruses. Identification of different aspects such as binding affinity, differential antigenic profiles of S-glycoproteins, and ACE2 mutations might influence the investigation of potential therapeutic strategies targeting SARS-CoV-2/ACE2 binding interface. In this review, we aim to elaborate on the expression of hACE2 receptor protein and its binding with SARS-CoV-2 S1 subunit, the possible immunogenic sequences of spike protein, effect of ACE 2 polymorphism on viral binding, and infectivity/susceptibility to disease. Furthermore, targeting of hACE2 receptor binding with SARS-CoV-2 S1 subunit via various mechanisms will be discussed to understand its role in therapeutics.

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