scholarly journals Noncoding RNAs in human cancer: one step forward in diagnosis and treatment

2016 ◽  
Vol 15 (3) ◽  
pp. 165-166
Author(s):  
Chunsheng Li ◽  
Lin Zhang
Keyword(s):  
Human Cancer ◽  
Noncoding Rnas ◽  
Diagnosis And Treatment ◽  
One Step

Prostate Carcinogenesis: Insights in relation to Epigenetics and Inflammation.

2020 ◽  
Vol 20 ◽  
Author(s):  
Mirazkar D. Pandareesh ◽  
Vivek Hamse Kameshwar ◽  
Kullaiah K. Byrappa
Keyword(s):  
Prostate Cancer ◽  
Epithelial Mesenchymal Transition ◽  
Human Cancer ◽  
Control Cell ◽  
Diagnosis And Treatment ◽  
Epigenetic Changes ◽  
Mesenchymal Transition ◽  
Prostate Carcinogenesis ◽  
History Of ◽  
Clinical Potential

: Prostate cancer is a multifactorial disease that mainly occurs due to the accumulation of somatic, genetic and epigenetic changes, resulting in the inactivation of tumor-suppressor genes and activation of oncogenes. Mutations in genes, specifically those that control cell growth and division or the repair of damaged DNA, make the cells grow and divide uncontrollably to form a tumor. The risk of developing prostate cancer depends upon the gene that has undergone the mutation. Identifying such genetic risk factors for prostate cancer pose a challenge for the researchers. Besides genetic mutations, many epigenetic alterations including DNA methylation, histone modifications (methylation, acetylation, ubiquitylation, sumoylation, and phosphorylation) nucleosomal remodelling, and chromosomal looping, have been significantly contributed to the onset of prostate cancer as well as the prognosis, diagnosis, and treatment of prostate cancer. Chronic inflammation also plays a major role in the onset and progression of human cancer, via. modifications in the tumor microenvironment by initiating epithelial-mesenchymal transition and remodelling the extracellular matrix. In this article, the authors present a brief history of the mechanisms and potential links between the genetic aberrations, epigenetic changes, inflammation and inflammasomes that are known to contribute to the prognosis of prostate cancer. Furthermore, the authors examine and discuss clinical potential of prostate carcinogenesis in relation to epigenetics and inflammation for its diagnosis and treatment.

One-Step Transformation from Rofecoxib to a COX-2 NIR Probe for Human Cancer Tissue/Organoid Targeted Bioimaging

2021 ◽  
Vol 4 (3) ◽  
pp. 2723-2731
Author(s):  
Lijun Xie ◽  
Renfu Li ◽  
Biyun Zheng ◽  
Zuoxu Xie ◽  
Xuefen Fang ◽  
...  
Keyword(s):  
Human Cancer ◽  
Cancer Tissue ◽  
One Step ◽  
Cox 2 ◽  
Human Cancer Tissue

scholarly journals The emerging role of super enhancer-derived noncoding RNAs in human cancer

Theranostics ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 11049-11062 ◽  
Author(s):  
Yutong Wang ◽  
Hui Nie ◽  
Xiaoyun He ◽  
Zhiming Liao ◽  
Yangying Zhou ◽  
...  
Keyword(s):  
Human Cancer ◽  
Noncoding Rnas ◽  
Super Enhancer

scholarly journals The emerging role of microRNAs and long noncoding RNAs in drug resistance of hepatocellular carcinoma

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ling Wei ◽  
Xingwu Wang ◽  
Liyan Lv ◽  
Jibing Liu ◽  
Huaixin Xing ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Human Cancer ◽  
Noncoding Rnas ◽  
Circular Rna ◽  
Long Noncoding Rnas ◽  
Protein Coding ◽  
Multiple Tumor ◽  
Nucleolar Rnas

Abstract Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the second most lethal human cancer. A portion of patients with advanced HCC can significantly benefit from treatments with sorafenib, adriamycin, 5-fluorouracil and platinum drugs. However, most HCC patients eventually develop drug resistance, resulting in a poor prognosis. The mechanisms involved in HCC drug resistance are complex and inconclusive. Human transcripts without protein-coding potential are known as noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small nucleolar RNAs (snoRNAs), long noncoding RNAs (lncRNAs) and circular RNA (circRNA). Accumulated evidences demonstrate that several deregulated miRNAs and lncRNAs are important regulators in the development of HCC drug resistance which elucidates their potential clinical implications. In this review, we summarized the detailed mechanisms by which miRNAs and lncRNAs affect HCC drug resistance. Multiple tumor-specific miRNAs and lncRNAs may serve as novel therapeutic targets and prognostic biomarkers for HCC.

scholarly journals The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer

2015 ◽  
Vol 48 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Zurab Siprashvili ◽  
Dan E Webster ◽  
Danielle Johnston ◽  
Rajani M Shenoy ◽  
Alexander J Ungewickell ◽  
...  
Keyword(s):  
Human Cancer ◽  
Noncoding Rnas
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