scholarly journals Functional and systems biology approaches to Huntington's disease

2011 ◽  
Vol 10 (3) ◽  
pp. 109-114 ◽  
Author(s):  
E. Gonzalez-Couto
Keyword(s):  
Systems Biology ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Taming the Huntington’s Disease Proteome: What Have We Learned?

2021 ◽  
pp. 1-19
Author(s):  
Connor Seeley ◽  
Kimberly B. Kegel-Gleason
Keyword(s):  
Biological Sciences ◽  
Mass Spectrometry ◽  
Systems Biology ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Interacting Proteins ◽  
Computational Approaches ◽  
Physical Technique ◽  
Precise Analysis ◽  
Disease Pathways

Mass spectrometry (MS) is a physical technique used to identify specific chemicals and molecules by precise analysis of their mass and charge; this technology has been adapted for biological sciences applications. Investigators have used MS to identify differential expressions of proteins in Huntington’s disease (HD), to discover Huntingtin (HTT) interacting proteins and to analyze HTT proteoforms. Using systems biology and computational approaches, data from MS screens have been leveraged to find differentially expressed pathways. This review summarizes the data from most of the MS studies done in the HD field in the last 20 years and compares it to the protein data reported before the use of MS technology. The MS results validate early findings in the field such as differential expression of PDE10a and DARPP-32 and identify new changes. We offer a perspective on the MS approach in HD, particularly for identification of disease pathways, the challenges in interpreting data across different studies, and its application to protein studies moving forward.

Sign in / Sign up

Export Citation Format

Share Document