scholarly journals Interesting times for microarray expression profiling

2009 ◽  
Vol 8 (3) ◽  
pp. 170-173 ◽  
Author(s):  
Y. Hey ◽  
S. D. Pepper
Keyword(s):  
Expression Profiling ◽  
Microarray Expression Profiling ◽  
Microarray Expression

Microarray expression profiling of tissues from mice with uniparental duplications of Chromosomes 7 and 11 to identify imprinted genes

2001 ◽  
Vol 12 (10) ◽  
pp. 758-764 ◽  
Author(s):  
Jonathan D. Choi ◽  
Lara A. Underkoffler ◽  
Joelle N. Collins ◽  
Shannon M. Marchegiani ◽  
Natalie A. Terry ◽  
...  
Keyword(s):  
Expression Profiling ◽  
Imprinted Genes ◽  
Microarray Expression Profiling ◽  
Microarray Expression

scholarly journals The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades

2004 ◽  
Vol 19 (3) ◽  
pp. 319-330 ◽  
Author(s):  
Harry Björkbacka ◽  
Katherine A. Fitzgerald ◽  
François Huet ◽  
Xiaoman Li ◽  
James A. Gregory ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiling ◽  
Adaptor Protein ◽  
Signaling Cascades ◽  
Macrophage Response ◽  
Live Bacteria ◽  
Microarray Expression Profiling ◽  
Molecular Brake ◽  
Microarray Expression ◽  
New Protein

Myeloid differentiation protein-88 (MyD88) is a signal adaptor protein required for cytokine production following engagement of Toll-like receptors (TLRs) by their cognate ligands. Activation of both TLR-3 and TLR-4, however, can engage signaling events independent of MyD88 expression. The relative importance of these MyD88-dependent and -independent signaling pathways in the macrophage response to lipopolysaccharide (LPS) is unknown. Here we define these events using microarray expression profiling of LPS-stimulated macrophages taken from MyD88-null and wild-type mice. Of the 1,055 genes found to be LPS responsive, only 21.5% were dependent on MyD88 expression, with MyD88-independent genes constituting 74.7% of the genetic response. This MyD88-independent gene expression was predominantly transcriptionally regulated, as it was unaffected by cycloheximide blockade of new protein synthesis. A previously undescribed group of LPS-regulated genes (3.8%), whose induction or repression was significantly greater in the absence of MyD88, was also identified by these studies. The regulation of these genes suggested that MyD88 could serve as a molecular brake, constraining gene activity in a subset of LPS-responsive genes. The findings generated with LPS stimulation were recapitulated by exposure of macrophages to live Escherichia coli. These expression-profiling studies redefine the current dogma of TLR-4 signaling and establish that MyD88, although essential for some of the best-characterized macrophage responses to LPS, is not required for the regulation of the majority of genes engaged by macrophage exposure to endotoxin or live bacteria.

scholarly journals Mouse strain specific gene expression differences for illumina microarray expression profiling in embryos

2012 ◽  
Vol 5 (1) ◽  
pp. 232 ◽  
Author(s):  
Petra Kraus ◽  
Xing Xing ◽  
Siew Lim ◽  
Max E Fun ◽  
V Sivakamasundari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mouse Strain ◽  
Expression Profiling ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Microarray Expression Profiling ◽  
Microarray Expression

scholarly journals Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

2017 ◽  
Vol 14 (2) ◽  
pp. 2523-2530 ◽  
Author(s):  
Ye Ding ◽  
Da-Zheng Yang ◽  
Yong-Ning Zhai ◽  
Kai Xue ◽  
Feng Xu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Expression Profiling ◽  
Microarray Expression Profiling ◽  
Non Coding Rnas ◽  
Microarray Expression
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