Bioavailability comparison between a compound comprising hesperetin-7-glucoside with β-cyclodextrin and a mixture of hesperidin and dextrin in healthy adult human males

The pharmacokinetics of compounds comprising hesperetin-7-glucoside with β-cyclodextrin and physically mixed hesperidin/dextrin were compared in eight healthy adult male subjects in a non-randomized, double-blind, cross-over, controlled study. For 0–24 h, the area under the curve of total plasma hesperetin concentration after hesperetin-7-glucoside with β-cyclodextrin consumption was >100-fold higher than that after hesperidin/dextrin consumption.