Tectorigenin attenuates cognitive impairments in mice with chronic cerebral ischemia by inhibiting the TLR4/NF-κB signaling pathway

2021 ◽  
Author(s):  
Wei Feng
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Signaling Pathway ◽  
Hippocampal Damage ◽  
Chronic Cerebral Ischemia ◽  
Mice Model ◽  
Related Factors ◽  
Ht22 Cells ◽  
Necrosis Factor Alpha ◽  
Hippocampal Tissue

Abstract This study aims to explore the effect of Tectorigenin in chronic cerebral ischemia (CCI)-induced cognitive impairment mice model. Cognitive impairment, hippocampal tissue histopathology and myelin density in CCI mice were detected. HT22 cells were used to induce oxygen-glucose deprivation/reperfusion (OGD/R) injury. Cells viability and apoptosis of transfected HT22 cells, toll-like receptor-4 (TLR4)/Nuclear factor-kappaB (NF-κB) pathway-related factors levels in hippocampal tissue and OGD/R models were detected. CCI caused cognitive impairment, hippocampal damage and decreased myelin density in mice while promoting interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α), TLR4, myeloid differentiation primary response gene 88 (MyD88), p-p65, NLRP3 and ASC levels. Tectorigenin reversed the effects of CCI in mice, and reversed the promoting effects of OGD/R on apoptosis and TLR4/NF-κB pathway-related factors levels, while overexpressed TLR4 reversed the effects of Tectorigenin in OGD/R-induced HT-22 cells. Tectorigenin alleviated cognitive impairment in CCI mice by inhibiting the TLR4/NF-κB signaling pathway.

scholarly journals Vascular cognitive impairment and chronic cerebral ischemia (dyscirculatory encephalopathy)

2019 ◽  
Vol 11 (3S) ◽  
pp. 61-67 ◽  
Author(s):  
V. A. Parfenov
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Emotional Disorders ◽  
Blood Lipid ◽  
Vascular Cognitive Impairment ◽  
Considerable Proportion ◽  
Secondary Headache ◽  
Chronic Cerebral Ischemia ◽  
Dyscirculatory Encephalopathy ◽  
Blood Clots

The paper reviews the literature on vascular cognitive impairment (VCI), the diagnosis widely used in foreign neurological practice, as well as chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP), the common diagnoses in Russian neurological practice. According to the etiology, risk factors, and manifestations, Stages I and II DEP largely corresponds to moderate VCI; Stage III DEP does to severe VCI. The results of the author’s studies show that a considerable proportion of patients followed up with a diagnosis of CCI, DEP, have no signs of chronic cerebrovascular disease (CVD), but suffer from primary or secondary headache, vertigo of various origins, emotional disorders, and other diseases. The diagnosis of CCI, DEP should be based on the presence of CCI, the reliable neuroimaging signs of chronic CVD, and the ruling out of other diseases. When treating and preventing VCI, CCI, and DEP, a premium is placed upon both non-drug (regular physical activity, smoking cessation, rational nutrition) and drug therapy aimed at normalizing blood pressure and blood lipid spectrum, preventing blood clots, and improving cognitive functions.

scholarly journals Exercise-Linked Irisin Prevents Mortality and Enhances Cognition in a Mice Model of Cerebral Ischemia by Regulating Klotho Expression

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Zhao Jin ◽  
Zongze Zhang ◽  
Jianjuan Ke ◽  
Yanlin Wang ◽  
Huisheng Wu
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ros Generation ◽  
Mice Model ◽  
Stroke Patients ◽  
Neuroprotective Effects ◽  
Protein Expressions ◽  
The Impact

Irisin, which can be released in the hippocampus after physical exercise, is demonstrated to have beneficial effects on neurovascular diseases. This study investigated the impact of exercise linked-irisin on mortality and cognition in a mice model of cerebral ischemia and further explored its underlying mechanism. The cerebrospinal concentrations of irisin and klotho from ischemic stroke patients were measured with an enzyme-linked immunosorbent assay (ELISA). The cognitive function of mice was evaluated by a series of behavioural experiments. The expressions of klotho, MnSOD, and FOXO3a in the hippocampus of mice were detected by Western blot. Superoxide production in the brain tissue of mice was evaluated with the dihydroethidium (DHE) dying. The results demonstrated that stroke patients showed a positive correlation between their CSF irisin concentration and klotho concentration. In addition, when mice subjected to cerebral ischemia, their cognitive function was impaired, the protein expressions of klotho, MnSOD, and FOXO3a downregulated, and the production of reactive oxygen species (ROS) increased compared with the sham group. After pretreatment with exogenous irisin, improved cognitive impairment, upregulated protein expressions of klotho, MnSOD, and FOXO3a, and reduced ROS generation were observed in mice with MCAO. However, the neuroprotective effects of irisin compromised with the evidence of severe cognitive impairment, decreased protein expressions of MnSOD and FOXO3a, and increased ROS production in klotho knockout mice. Thus, our results indicated that exercise-linked irisin could prevent mortality and improve cognitive impairment after cerebral ischemia by regulating klotho expression.

scholarly journals Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Shu Zhu ◽  
Dongyu Min ◽  
Jianhong Zeng ◽  
Yetao Ju ◽  
Yao Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Neuronal Apoptosis ◽  
Deciduous Teeth ◽  
Stem Cell Population ◽  
Chronic Cerebral Ischemia ◽  
Nervous Disease ◽  
Human Exfoliated Deciduous Teeth

Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population with high self-renewal ability that originates from the cranial neural crest. Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. However, whether and how SHED ameliorate degenerative central nervous disease are unclear. Chronic cerebral ischemia (CCI) is a kind of neurological disease caused by long-term cerebral circulation insufficiency and is characterized by progressive cognitive and behavioral deterioration. In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. Mechanistically, SHED transplantation decreased the apoptosis of neuronal cells in the hippocampus area of CCI rats through downregulation of cleaved caspase-3. In summary, SHED transplantation protected the neuronal function and reduced neuronal apoptosis, resulting in amelioration of cognitive impairment from CCI. Our findings suggest that SHED are a promising stem cell source for cell therapy of neurological diseases in the clinic.

FEATURES OF COGNITIVE IMPAIRMENT DEPENDING ON THE STAGE OF CHRONIC CEREBRAL ISCHEMIA

2021 ◽  
Vol 2 (1) ◽  
pp. 56-61
Author(s):  
Munis Dilshod qizi Fayzieva ◽  
◽  
Durdona Djurabaevna Usmanova
Keyword(s):  
Adverse Effect ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Neurological Disorders ◽  
Cognitive Disorders ◽  
Chronic Cerebral Ischemia ◽  
Common Cause ◽  
Local Factors ◽  
Atherosclerotic Stenosis ◽  
Stenosis And Occlusion

The article presents the results of the analysis of literature sources on chronic cerebral ischemia, etiology and pathogenetic mechanisms of the development of cognitive impairment. In the pathogenesis of chronic cerebral ischemia, systemic and local factors are important, leading to disorders of cerebral hemodynamics, the most adverse effect is exerted by their combination. The most common cause of local disorders of cerebral blood flow is atherosclerotic stenosis and occlusion of intracerebral and extracranial vesselsthat perform transport and distribution functions.Keywords: chronic cerebral ischemia, cognitive disorders, neurological disorders

scholarly journals Clinical manifestations and issues of diagnosis of chronic cerebrovascular disease (chronic cerebral ischemia) at an early (pre-dementia) stage

2021 ◽  
Vol 13 (1) ◽  
pp. 4-12
Author(s):  
A. A. Kulesh ◽  
A. Yu. Emelin ◽  
A. N. Bogolepova ◽  
O. B. Doronina ◽  
V. V. Zakharov ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Cerebrovascular Disease ◽  
Emotional Disorders ◽  
Clinical Manifestations ◽  
Primary Headache ◽  
Chronic Cerebral Ischemia ◽  
Common Diagnosis ◽  
Long Time ◽  
Vestibular Vertigo

The paper presents experts' opinion on the clinical manifestations and diagnosis of chronic cerebrovascular disease (CVD) (chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP)) at the pre-dementia stage. It is noted that DEP/CCI is a common diagnosis in Russian neurological practice, the criteria for which have not been updated for a long time. DEP/CCI most often develops in the presence of cerebral small artery (CSA) disease (cerebral microangiopathy (CMA)), the severity of which can be quantified by magnetic resonance imaging. The main clinical manifestation of DEP/CCI is cognitive impairment that may be subjective or moderate at the pre-dementia stage. Emotional disorders (apathy, depression, anxiety) and instability are considered as possible manifestations of CSA disease. It is noted that headache and vestibular vertigo are not caused by chronic CVD; while in patients with CMA, they are usually associated with other diseases (primary headache, peripheral vestibular vertigo, and vestibular migraine). The diagnosis of DEP/CCI should be based on the presence of cognitive impairment, reliable neuroimaging signs of CVD, and the exclusion of another cause of cognitive impairment.

scholarly journals Balneotherapy and physiotherapy in treatment of cognitive and psychoemotional disorders in patients with chronic cerebral ischemia

2020 ◽  
Vol 17 (4) ◽  
pp. 178-184
Author(s):  
Lyubov A. Cherevaschenko ◽  
Artem A. Serebryakov ◽  
Nikolay N. Kulikov ◽  
Anatolii T. Tereshin ◽  
Igor A. Cherevashchenko
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Electrostatic Field ◽  
Low Frequency ◽  
Chronic Cerebral Ischemia ◽  
Health Resort ◽  
Treatment Methods ◽  
Treatment Stage

Background. Chronic cerebral ischemia, or discirculatory encephalopathy, is one of the most common neurological diagnosis in Russia. This condition is defined as a chronic, progressive, non-stroke-related vascular lesion of the brain, which is manifested predominantly by cognitive impairment. Therapeutic measures for cognitive impairment include, first of all, the prevention of acute cerebrovascular accidents and chronic vascular cerebral insufficiency. The development and implementation of highly effective non-drug treatment methods, having few side effects, is an urgent problem in contemporary medicine. Such treatment methods can include balneotherapy and physiotherapy. Aim: to justify the possibility and expediency of applying at the health resort treatment stage the combined use of iodine-bromine baths and a pulsed low-frequency electrostatic field in patients with chronic cerebral ischemia in order to correct cognitive and psychoemotional disorders and improve the quality of life. Methods. The study included 90 patients with chronic cerebral ischemia, who were randomly divided into 3 treatment groups. The control group patients received iodine-bromine baths, the comparison group patients received exposure to an alternating pulsed low-frequency electrostatic field using the HIVAMAT-200 apparatus, and the main group patients received iodine-bromine baths and exposure to a pulsed low-frequency electrostatic field. The cognitive and emotional-volitional sphere was studied using standard neuropsychological techniques, namely the minimum cognitive deficit scale Mini Mental State Examination (MMSE); Lurias test, the Clock Drawing test, Schulte tables, and Yu.L. Hanins anxiety scales. The study of quality of life was performed using the Russian version of the general questionnaire MOS SF 36 Iterm Short-Form Health Survey. Results. It has been proved that as a result of treatment, disorders of memory and attention are reduced, the general cognitive status of patients is improved, which slows down the disease progression, reduces the risk of vascular catastrophes and dementia. Conclusion. New medical technologies developed for the treatment of patients with chronic cerebral ischemia at the health resort treatment stage are highly effective, pathogenetically substantiated, and can be recommended for widespread use in a network of health resort institutions and rehabilitation and preventive institutions of practical health care.

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