scholarly journals The Neuropsychological Profile and Phenomenology of Late Onset Psychosis: A Cross-sectional Study on the Differential Diagnosis of Very-Late-Onset Schizophrenia-Like Psychosis, Dementia with Lewy Bodies and Alzheimer’s Type Dementia with Psychosis

2018 ◽  
Vol 34 (2) ◽  
pp. 183-199 ◽  
Author(s):  
Lies Van Assche ◽  
Evelyne Van Aubel ◽  
Lucas Van de Ven ◽  
Filip Bouckaert ◽  
Patrick Luyten ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Dementia With Lewy Bodies ◽  
Late Onset ◽  
Lewy Bodies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Neuropsychological Profile

scholarly journals Respiratory dysrhythmia in dementia with Lewy bodies: a cross-sectional study

BMJ Open ◽  
2013 ◽  
Vol 3 (9) ◽  
pp. e002870 ◽  
Author(s):  
Shinichiro Hibi ◽  
Yasuhiro Yamaguchi ◽  
Yumi Umeda-Kameyama ◽  
Katsuya Iijima ◽  
Miwako Takahashi ◽  
...  
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Platelet miRNA bio-signature discriminates between dementia with Lewy bodies and Alzheimer disease

2020 ◽  
Author(s):  
Ana Gámez-Valero ◽  
Jaume Campdelacreu ◽  
Dolores Vilas ◽  
Lourdes Ispierto ◽  
Daniela Samaniego ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dementia With Lewy Bodies ◽  
Correct Diagnosis ◽  
Lewy Bodies ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Sectional Study ◽  
Cross Sectional ◽  
Disease Biomarkers

ABSTRACTDementia with Lewy bodies (DLB) is one of the most common causes of degenerative dementia after Alzheimer’s disease (AD) and presents pathological and clinical overlap with both AD and Parkinson’s disease (PD). Consequently, only one in three DLB cases is diagnosed correctly. Platelets, previously related to neurodegeneration, contain microRNAs (miRNAs) whose analysis may provide disease biomarkers. Here, we profiled the whole platelet miRNA transcriptome from DLB patients and healthy controls. Differentially expressed miRNAs were further validated in three consecutive studies from 2017 to 2019 enrolling 162 individuals, including DLB, AD, and PD patients, and healthy controls. Results comprised a 7-miRNA biosignature, showing the highest diagnostic potential for the differentiation between DLB and AD. Additionally, compared to controls, two miRNAs were down-regulated in DLB, four miRNAs were up-regulated in AD, and two miRNAs were down-regulated in PD. Predictive target analysis identified three disease-specific clusters of pathways as a result of platelet-miRNA deregulation. Our cross-sectional study assesses the identification of a novel, highly specific and sensitive platelet-associated miRNA-based bio-signature, which distinguishes DLB from AD.The paper explainedProblemDementia with Lewy bodies (DLB) presents pathological and clinical overlap with both Alzheimer’s (AD) and Parkinson’s disease (PD), which impairs its correct diagnosis. Although numerous papers report peripheral biomarkers for AD, well-established biomarkers for DLB distinguishing it from AD are still missing. Platelet miRNA transcriptome was analyzed in several works, but their putative role as disease biomarkers for neurological disorders has not been assessed. It would be of paramount importance to establish a blood-based bio-signature as a minimally invasive mean for DLB diagnosis, improving differentiation of DLB patients from controls and AD.ResultsOur study revealed that platelet miRNAs might be promising biomarkers for the correct diagnosis of DLB stratifying patients in comparison with overlapping disorders, especially AD, and may help to highlight possible disease-related processes. In this cross-sectional study, which includes 162 individuals (DLB, AD, PD and healthy controls), platelet-associated miRNA content was disease group-specific. Three different miRNA sets together with their predicted targeted pathways were defined.ImpactThis study suggests that platelet miRNA may serve as DLB biomarker allowing the correct diagnosis and stratification in an easily-applied manner in clinical settings, and may help to highlight possible disease-related processes.

Admixture analysis of age at onset in older patients with schizophrenia spectrum disorders

2020 ◽  
Vol 32 (6) ◽  
pp. 781-785
Author(s):  
Maureen M. J. Smeets-Janssen ◽  
Idan M. Aderka ◽  
Paul D. Meesters ◽  
Sjors Lange ◽  
Sigfried Schouws ◽  
...  
Keyword(s):  
Late Onset ◽  
Age At Onset ◽  
Cross Sectional Study ◽  
Data Driven ◽  
Admixture Analysis ◽  
Schizophrenia Spectrum Disorders ◽  
Sectional Study ◽  
Cross Sectional ◽  
Schizophrenia Spectrum ◽  
Spectrum Disorders

ABSTRACTThe nature of schizophrenia spectrum disorders with an onset in middle or late adulthood remains controversial. The aim of our study was to determine in patients aged 60 and older if clinically relevant subtypes based on age at onset can be distinguished, using admixture analysis, a data-driven technique. We conducted a cross-sectional study in 94 patients aged 60 and older with a diagnosis of schizophrenia or schizoaffective disorder. Admixture analysis was used to determine if the distribution of age at onset in this cohort was consistent with one or more populations of origin and to determine cut-offs for age at onset groups, if more than one population could be identified. Results showed that admixture analysis based on age at onset demonstrated only one normally distributed population. Our results suggest that in older schizophrenia patients, early- and late-onset ages form a continuum.

Executive functions and basic symptoms in adolescent antisocial behavior: A cross-sectional study on an Italian sample of late-onset offenders

2014 ◽  
Vol 55 (3) ◽  
pp. 631-638 ◽  
Author(s):  
Maria Rosaria A. Muscatello ◽  
Giuseppe Scimeca ◽  
Gianluca Pandolfo ◽  
Umberto Micò ◽  
Vincenzo M. Romeo ◽  
...  
Keyword(s):  
Executive Functions ◽  
Antisocial Behavior ◽  
Late Onset ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Basic Symptoms ◽  
Italian Sample
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