scholarly journals Examining Normative Reference Values and Item-Level Symptom Endorsement for the Quality of Life in Neurological Disorders (Neuro-QoL™) v2.0 Cognitive Function-Short Form

2020 ◽  
Author(s):  
Grant L Iverson ◽  
Eric J Connors ◽  
Jacqueline Marsh ◽  
Douglas P Terry
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Cognitive Function ◽  
Neurological Disorders ◽  
Short Form ◽  
Cognitive Symptoms ◽  
Cognitive Difficulties ◽  
Base Rates ◽  
Item Level

Abstract Objective We examined the normative reference values, item-level symptom endorsement, internal consistency reliability, and the base rates of symptoms endorsed for the quality of life in neurological disorders (Neuro-QoL™) v2.0 Cognitive Function-Short Form. Method The Neuro-QoL™ v2.0 Cognitive Function-Short Form measures subjective cognitive difficulties. The normative sample from the U.S. general population was stratified by gender, education, health status, self-reported diagnosis of depression or anxiety, and recent mental health symptoms (i.e., endorsed frequent anxiety or depression symptoms in the last week). Results A cohort of 1,009 adults completed this scale and their mean score was 32.60 (SD = 6.89). The base rates of those who reported zero cognitive symptoms were consistently higher among the healthy samples (healthy men = 79.2%; all men = 63.9%; healthy women = 90.2%; all women = 80.0%). Endorsing three or more cognitive symptoms was more common in the mental health subgroups for both men (full men’s sample [n = 493] = 17.6%; depression subgroup [n = 70] = 30.0%; anxiety subgroup [n = 61] = 29.5%; mental subhealth group [n = 70] = 38.6%) and women (full women’s sample [n = 516] = 7.4%; depression subgroup [n = 123] = 13.0%; anxiety subgroup [n = 103] = 12.6%; mental health subgroup [n = 101] = 14.9%). Internal consistency was measured using Cronbach’s α and ranged from 0.87 to 0.94 across groups. Conclusions The Neuro-QoL™ v2.0 Cognitive Function-Short Form is a brief, efficient, and reliable measure of perceived cognitive difficulties. As expected, individuals with a favorable overall health and quality of life reported less cognitive symptoms than the total sample, whereas individuals with mental health difficulties reported more. These normative values and base rates stratified by gender, overall health, and mental health status may be useful when interpreting this measure in clinical practice.

scholarly journals QOLP-27. USE OF THE NEURO-QOL COGNITIVE FUNCTION SHORT-FORM AS A TOOL FOR ASSESSING PATIENT-PERCEIVED NEUROCOGNITION FOLLOWING RADIOTHERAPY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii180-ii181
Author(s):  
Sung Choi ◽  
Emily Kowalski ◽  
Rahul Khairnar ◽  
Mark Mishra
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Neurological Disorders ◽  
Short Form ◽  
Minimum Clinically Important Difference ◽  
Primary Objective ◽  
Study Cohort ◽  
Tumor Type

Abstract The Quality-of-Life in Neurological Disorders (Neuro-QOL) instruments are a practical set of validated tools utilized to measure a core set of health-related quality-of-life parameters that are relevant to patients with neurological disorders. The tools can be completed in approximately 1-minute. The primary objective of this study was to evaluate the feasibility of utilizing the eight-question Neuro-QoL Cognitive Function- Short Form (NCF-SF) tool (v2.0) to assess cognitive outcomes in patients with primary and secondary brain tumors undergoing radiotherapy. Patients completed the NCF-SF at baseline and during follow-up visits. Raw scores were converted to a standardized T-score that has been normalized to have mean score of 50 and standard deviation (SD) of 10. Descriptive statistical analyses were performed to assess the prevalence of baseline cognitive impairment (defined as > 1 SD below the normative mean), and to assess longitudinal changes in Neuro-QOL scores. A minimum clinically important difference (MCID) was defined as a change from baseline of >7.5, based on previously published literature. Ninety-one patients completed NCF-SF at baseline and at least one follow-up visit. The mean baseline score for the study cohort was 49.9 (SD 9.2). Nineteen percent of patients (n=17/91) had impaired function at baseline. Baseline scores did not differ based on tumor type (p=0.79): Glioma/ependymoma 49.6 (n=35); brain metastases 49.1 (n=24); Meningioma/benign 50.7 (n=32). Following radiation, 15% and 22% of patients experienced a MCID decline at 1- (n=60) and 3- months (n=65), respectively. However, 17% and 20% of patients demonstrated a MCID improvement at 1- and 3-months, respectively. In conclusion, this represents the first study to utilize the NCF-SF to measure cognitive function in patients undergoing brain radiotherapy. Use of NCG-SF was feasible, and identified patients with meaningful changes in cognitive function over time. Future clinical trials may consider use of Neuro-QOL to assess patient-perceived cognitive function.

scholarly journals A-242 Examining Normative Reference Values and Item-Level Symptom Endorsement for the Neuro-QoLTM v2.0 Cognitive Function-Short Form

2020 ◽  
Vol 35 (6) ◽  
pp. 1037-1037
Author(s):  
Iverson G ◽  
Connors E ◽  
Marsh J ◽  
Terry D
Keyword(s):  
Cognitive Function ◽  
Internal Consistency ◽  
Reference Values ◽  
Short Form ◽  
Internal Consistency Reliability ◽  
Healthy Men ◽  
Cognitive Difficulties ◽  
Base Rates ◽  
Healthy Women ◽  
Item Level

Abstract Objective We examined the normative reference values, item-level symptom endorsement, internal consistency reliability, and the base rates of symptoms endorsed for the Neuro-QoLTM v2.0 Cognitive Function-Short Form. Method The Neuro-QoLTM v2.0 Cognitive Function-Short Form is a fixed 8-item scale that measures subjective cognitive functioning. Raw scores range from 8–40, with higher scores indicating less cognitive concerns. Adults from the general US population completed the scale. The sample was stratified by gender and health status. Individuals were included in the healthy subgroup if they reported no personal history of mental health, neurological, or sleep disorders and rated their overall health, functioning, and quality of life as “good” or better. Results A normative sample of 1,009 adults completed this scale and their mean score was 32.60 (SD = 6.89). The healthy subgroup (n = 475) had a higher mean, suggesting less perceived cognitive difficulties (M = 35.12, SD = 5.57). This pattern was consistent for men (all men, M = 31.26, SD = 7.10; healthy men, M = 33.86, SD = 5.95) and women (all women, M = 33.89, SD = 6.43; healthy women, M = 36.42, SD = 4.85). The base rates of those who reported zero cognitive symptoms were consistently higher among the healthy samples (healthy men = 79.2%; all men = 63.9%; healthy women = 90.2%; all women = 80.0%). Internal consistency was measured using Cronbach’s alpha and ranged from 0.87 to 0.94 across groups. Conclusions The Neuro-QoLTM v2.0 Cognitive Function-Short Form is a brief, efficient, and reliable measure of perceived cognitive difficulties. The subgroup normative reference values and base rate analyses of individual symptom endorsement presented herein can be used by clinicians and researchers for a more refined interpretation of the scale.

scholarly journals A-237 Investigating the Reliability and Item-Level Symptom Endorsement for the PROMIS® v2.0 Cognitive Function-8-Item Short Form

2020 ◽  
Vol 35 (6) ◽  
pp. 1032-1032
Author(s):  
Iverson G ◽  
Marsh J ◽  
Connors E ◽  
Terry D
Keyword(s):  
Health Status ◽  
Cognitive Function ◽  
Reference Values ◽  
Short Form ◽  
Total Sample ◽  
Cognitive Symptoms ◽  
Healthy Men ◽  
Cognitive Difficulties ◽  
Item Level ◽  
Healthy Sample

Abstract Objective We present the normative reference values, item level endorsement, and the internal consistency reliability of the PROMIS® v2.0 Cognitive Function-8-Item Short Form. Method The PROMIS® v2.0 Cognitive Function 8-Item Short Form measures subjective cognitive difficulties (raw score range = 8–40). A cohort of 1,009 adults (51.1% women) from the US population completed this measure. The total sample was stratified by gender and health status for analyses. A healthy subgroup (n = 475; 49.5% women) reported no personal history of mental health, neurological, or sleep disorders and rated their overall health, functioning, and quality of life as “good” or better. Results The healthy group reported less cognitive symptoms (i.e., higher raw score) than the total sample (total sample, M = 32.17, SD = 7.57, Md = 34; healthy sample, M = 35.02, SD = 5.94, Md = 38). This pattern was shown in men [all men, M = 31.06, SD = 7.68, Md = 32; healthy men, M = 33.95, SD = 6.34, Md = 36] and women [all women, M = 33.23, SD = 7.32, Md = 36; healthy women, M = 36.12, SD = 5.30, Md = 39]. The base rates for endorsing three or more cognitive symptoms were consistently lower among the healthy samples (total sample = 14.8%, total healthy sample = 4.8%, all men = 19.7%, healthy men = 7.5%, all women = 10.1%, and healthy women = 2.1%). Internal consistency, as measured by Cronbach’s alpha, ranged from 0.89 to 0.95 depending on subgroup. Conclusions The PROMIS® v2.0 Cognitive Function 8-Item Short Form is a reliable self-report measure of cognitive difficulties. Participants who reported their overall health status to be good tended to report less cognitive difficulties. The presented normative reference values can be useful in both research and clinical practice when assessing cognition in the general population.

scholarly journals Mindfulness in Motion for People with Multiple Sclerosis: A Feasibility Study

2017 ◽  
Vol 19 (5) ◽  
pp. 225-231 ◽  
Author(s):  
Rachel M. Gilbertson ◽  
Maryanna D. Klatt
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Multiple Sclerosis ◽  
Mindfulness Meditation ◽  
Short Form ◽  
Physical Symptoms ◽  
Future Research ◽  
Five Facet Mindfulness Questionnaire ◽  
Anxiety Depression

Background: Mindfulness in Motion is an 8-week mindfulness-based intervention that uses yoga movement, mindfulness meditation, and relaxing music. This study examined the feasibility of using Mindfulness in Motion in people with multiple sclerosis (MS) and the effect of this program on stress, anxiety, depression, fatigue, and quality of life in people with MS. Methods: Twenty-two people with MS completed the 8-week mindfulness program as well as assessments 1 week before and after the intervention. Results: Pre/post comparison of four self-reported questionnaires—the Mental Health Inventory, 36-item Short Form Health Status Survey, Modified Fatigue Impact Scale, and Five Facet Mindfulness Questionnaire—showed significant improvement in physical functioning, vitality, and mental health. Specifically, improvements were seen in anxiety, depression, and positive affect; cognitive, psychosocial, and overall functioning regarding fatigue; and mindfulness in the areas of observing, acting with awareness, nonjudgment, and nonreactivity. Conclusions: Due to the uncertainty in disease progression associated with MS, and the multiplicity of mental and physical symptoms associated with it, programming that addresses anxiety, depression, and fatigue is a key area of future research in MS disease management. Mindfulness in Motion proved to be a feasible program yielding positive results, supporting the need for research to determine the extent to which the program can improve quality-of-life outcomes for people with MS.

scholarly journals How different domains of quality of life are associated with latent dimensions of mental health measured by GHQ-12

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Fatemeh Nouri ◽  
Awat Feizi ◽  
Hamidreza Roohafza ◽  
Masoumeh Sadeghi ◽  
Nizal Sarrafzadegan
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Cohort Study ◽  
Physical Health ◽  
Social Relationships ◽  
Rural Areas ◽  
Clinical Symptoms ◽  
Short Form ◽  
Environmental Condition

Abstract Background and objectives A short form of the General Health Questionnaire (GHQ-12) is a useful screening instrument for assessing mental health. Furthermore, Quality of life (QoL) is a critical treatment outcome in many clinical and health care research settings. This study aimed to reassess the dimensionality of GHQ-12 using Multidimensional Graded Response Model (MGRM) and evaluate how its extracted dimensions are associated with the QoL's domains. Methods Isfahan Cohort Study 2 (ICS2) is a population-based, ongoing prospective cohort study among adults aged 35 years and older who were free of cardiovascular diseases (CVDs) at the beginning of the study in 2013. A total of 1316 participants, all living in urban and rural areas of Isfahan and Najafabad, Iran was completed the GHQ-12 and WHO QoL-brief version at baseline. Five competing MGRMs with different latent structures were specified for GHQ-12. Factor scores derived from the best fitted model were used to associate with various domains of QoL. Results: The Three-Dimensional model for GHQ-12 was the best-fitted model explaining the Social Function (SF), Self Confidence (SC), and Anxiety/Depression (A/D) as three correlated yet different latent dimensions of mental health. Our findings in full adjusted multivariate regression models showed that a one-SD increase in dimensions of SC and SF was associated with a 38- to 48%-SD and 27- to 38%-SD increase in the domains scores of QoL, respectively. Moreover, for each one‐SD increase in score of A/D dimension, the domains scores of QoL decreased by 29- to 40%-SD. The highest to the lowest standardized coefficients for all latent dimensions of mental health were respectively related to the psychological, physical health, social relationships, and environmental condition domains of QoL. Furthermore, SC, A/D, and SF dimensions of GHQ-12 showed the highest to the lowest degree of association with all domains of QoL. Conclusions Our findings confirm that the GHQ-12 as a multidimensional rather than unitary instrument measures distinct dimensions of mental health. Furthermore, all aspects of QoL changed when the intensity of latent dimensions of mental health increased. Moreover, the psychological domain of QoL is the most affected by all latent dimensions of mental health, followed by physical health, social relationships, and environmental condition domains. It seems that in an attempt to full recovery as assessed by improved QoL outcomes, treatment of clinical symptoms may not be sufficient. Identifying and differentiating the structures of mental health in each community as well as implementing intervention programs aimed at focusing on specific dimensions may help in the prevention of further deterioration of mental health and improved QoL in the community.

Abstract WP445: Age Differences in the Impact of Sleep Apnea on Cognition and Quality of Life

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Kristin J Addison-Brown ◽  
Abraham J Letter ◽  
Henry K Yaggi ◽  
Leslie A McClure ◽  
Frederick W Unverzagt ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sleep Apnea ◽  
Cognitive Function ◽  
High Risk ◽  
Racial Differences ◽  
Short Form ◽  
Epidemiological Studies ◽  
Obstructive Sleep ◽  
The Impact

Introduction: Using a subsample from the national REasons for Geographic And Racial Differences in Stroke (REGARDS) study, we examined the associations of obstructive sleep apnea (OSA) with cognition and quality of life and whether these associations vary with age while controlling for other demographic factors and comorbid medical conditions. Methods: Stroke-free participants with complete data on OSA risk, cognition, and quality of life as of October 2010 were included (N =2,925; ages 47-93, 43% men, 35% black, 65% white). OSA risk was defined as high or low based on responses to the Berlin Sleep Questionnaire (BSQ). Cognitive function was assessed with three validated fluency and recall measures; quality of life was assessed with the 4-item Center for Epidemiological Studies-Depression (CESD-4) scale and the Medical Outcomes Study Short Form-12 (SF-12). MANCOVA statistics were applied to the cognitive and quality of life outcomes separately while accounting for potential confounders (age, sex, race, education, diabetes and dyslipidemia). Body mass index and hypertension were taken into account as part of the BSQ definition of OSA risk. Results: In fully adjusted models, those at high risk for OSA had significantly lower cognitive scores (p < .05) and lower quality of life (depressive symptoms and SF-12) (p < .0001) than those at low risk. Some of the associations were age-dependent, such that younger participants with high OSA risk had worse cognitive and quality of life scores than both younger participants with low OSA risk and older participants with high OSA risk. Discussion: Lower cognitive function and lower quality of life in those at high risk for sleep apnea remained after accounting for potentially confounding factors in a population-based sample. These relationships were more pronounced during middle age, with attenuated effects after age 70. It may be of particular importance to detect and treat OSA in younger adults.

Quality of Life and Mental Health in Brazilian Women Treated for Invasive Carcinoma of the Cervix

2014 ◽  
Vol 24 (4) ◽  
pp. 794-799
Author(s):  
Gabriela A. Caixeta ◽  
Emma E. C. Castro ◽  
Agnaldo L. Silva-Filho ◽  
Fernando M. Reis ◽  
José R. Cunha-Melo ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Life Events ◽  
General Health ◽  
Invasive Carcinoma ◽  
Short Form ◽  
General Health Questionnaire ◽  
Control Group ◽  
History Of

ObjectiveThe objective of this study was to compare the quality of life (QOL) and mental health (MH) of women surviving at least 2 years after treatment for invasive carcinoma of the cervix by radical hysterectomy (RH), chemotherapy and/or radiotherapy, or by surgery followed by adjuvant therapy (RH + chemotherapy and/or radiotherapy). The QOL/MH of a control group of women with no history of malignancy was also assessed for comparison with the treated groups.MethodsThe levels of QOL and MH were assessed in 114 Brazilian women (57 patients with an average of 4 years since treatment completion and 57 control subjects). The 36-item Medical Outcomes Study Short-Form Health Survey, the State-Trait Anxiety Inventory, the 12-item General Health Questionnaire, the Life Events Inventory, and a general survey for the assessment of sociodemographic data were applied to each participant of the study.ResultsNo differences were noted among the 3 treatment groups or between these and the control group concerning the levels of QOL (either physical or MH aspects), anxiety, general health, or life events. However, lower levels of anxiety were detected in cancer survivors when compared with the control group (P = 0.035).ConclusionsAfter at least 2 years, the QOL and the MH of Brazilian women treated for invasive carcinoma of the cervix were similar to those of women without malignancy and were not affected by the modality of treatment.

scholarly journals Quality of Life of Informal Caregivers behind the Scene of the COVID-19 Epidemic in Serbia

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 647
Author(s):  
Natasa Todorovic ◽  
Milutin Vracevic ◽  
Nina Rajovic ◽  
Vedrana Pavlovic ◽  
Petar Madzarevic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Family Member ◽  
Short Form ◽  
Informal Caregivers ◽  
Care Recipient ◽  
Level Of Care ◽  
Physical And Mental Health ◽  
Cross Sectional

Background and objectives: The COVID-19 pandemic has had an unprecedented reliance on informal caregivers as one of the pillars of healthcare systems. The aim of this study was to assess the quality of life of informal caregivers during the COVID-19 epidemic in Serbia. Materials and Methods: A cross-sectional study was conducted among informal caregivers during the COVID-19 epidemic in Serbia. Physical and mental quality of life was measured by the 36-Item Short-Form Health Survey. Additional data included sociodemographic characteristics, caregiver and care recipient characteristics, and COVID-19 related concerns. The qualitative component was performed using focus groups and individual in-depth interviews. Results: Out of 112 informal caregivers enrolled, most were female (80%), and the average age was 51.1 ± 12.3 years. The majority was delivering care to one person, who was a family member, on a daily basis (86.4%, 92%, and 91.1%, respectively). In multiple regression models, significant predictors of caregivers’ physical health were delivering care to a family member and a higher level of care complexity, while significant predictors of caregivers’ mental health were a higher level of care complexity and increased concerns about self-health and the health of the person being cared for due to the COVID-19 epidemic. Conclusions: Informal caregivers are experiencing negative physical and mental health outcomes during the COVID-19 epidemic in Serbia.

Development of the Sport Mental Health Continuum—Short Form (Sport MHC-SF)

2019 ◽  
Vol 13 (4) ◽  
pp. 593-608 ◽  
Author(s):  
Brian J. Foster ◽  
Graig M. Chow
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Convergent Validity ◽  
Short Form ◽  
Measurement Instrument ◽  
Collegiate Athletes ◽  
Well Being ◽  
Emotional Quality ◽  
Context Specific

Well-being research conducted in competitive athletics has been marred by the lack of a context-specific measurement instrument. The purpose of this study was to adapt the Mental Health Continuum – Short Form (MHC-SF) to create a sport-specific well-being instrument, the Sport Mental Health Continuum—Short Form (Sport MHC-SF), and test its initial psychometric properties. Participants were 287 collegiate athletes from a variety of sports. Confirmatory factor analysis (CFA) determined a three-factor structure of sport well-being, consisting of subjective, psychological, and social factors, as the model of best fit. Internal consistency reliabilities of the subscales exceeded .88. Moderate positive correlations were found between Sport MHC-SF subscales and quality of life indices, notably physical and emotional quality of life, demonstrating convergent validity. The Sport MHC-SF will facilitate empirical research by providing a more accurate and comprehensive measurement of well-being for an athletic population.

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