scholarly journals Genetic testing in young women with breast cancer: results from a Web-based survey

2010 ◽  
Vol 21 (4) ◽  
pp. 741-747 ◽  
Author(s):  
K.J. Ruddy ◽  
S. Gelber ◽  
J. Shin ◽  
J.E. Garber ◽  
R. Rosenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Testing ◽  
Young Women ◽  
Web Based

Genetic testing in young women with breast cancer: Results from a web-based survey

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 21093-21093
Author(s):  
J. A. Shin ◽  
S. Gelber ◽  
J. Garber ◽  
R. Rosenberg ◽  
M. Przypyszny ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Genetic Testing ◽  
Family History ◽  
High Risk ◽  
Young Women ◽  
College Education ◽  
Web Based ◽  
Increased Risk ◽  
History Of

21093 Background: Young women with breast cancer have an increased risk of harboring a BRCA1/2 mutation. The frequency of genetic testing in this population is not well described. We evaluated the reported frequency and factors associated with genetic testing among young breast cancer survivors identified through the Young Survival Coalition (YSC), an international advocacy group for young women with breast cancer. Methods: Items regarding family history and genetic testing were included in a large web-based survey addressing quality of life and fertility issues for young women with breast cancer. All YSC members were invited by email in March 2003 (N= 1,703 women) to participate in this cross-sectional survey. Results: 657 women completed the on-line survey; 622 were eligible for this analysis (age <40, no metastatic or recurrent disease). Mean age at breast cancer diagnosis was 33 years; mean age when surveyed 35.5 years. Stages included: 0 (10%), I (27%), II (49%), III (12%), missing (3%). 90% of women were white; 64% married; 49% with children; 78% had at least a college education; 42% of women reported a 1st or 2nd degree relative with breast or ovarian cancer, and 13% considered themselves high-risk for harboring a genetic mutation at the time of diagnosis. At the time of the survey, 23% of women had undergone genetic testing, and 26% of those tested reported that a mutation was found. In a multivariate model, women who were younger (age 36–40 vs. age =30, O.R. 2.26, p=0.004), more educated (< college vs. > college education, O.R. 2.62, p=0.0009), had a family history of breast or ovarian cancer (O.R. 3.15, p<0.0001), and had had a mastectomy (O.R. 1.99, p=0.001) were more likely to have undergone genetic testing. Non-significant covariates included: age at survey, stage, time since diagnosis, race, marital status, employment, finances, insurance, number of children, comorbidities, baseline anxiety and depression, and fear of recurrence. Conclusion: The majority of women diagnosed with breast cancer age 40 and younger do not undergo genetic testing. Younger, more educated women with a family history of breast or ovarian cancer are more likely to get tested. Further research to define the appropriateness of genetic testing in this relatively high-risk population is warranted. No significant financial relationships to disclose.

Young, Empowered and Strong: A Web-Based Education and Supportive Care Intervention for Young Women With Breast Cancer Across the Care Continuum

2021 ◽  
pp. 933-943
Author(s):  
Tal Sella ◽  
Craig Snow ◽  
Hannah Freeman ◽  
Philip D. Poorvu ◽  
Shoshana M. Rosenberg ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Breast Cancer Survivors ◽  
Metastatic Breast ◽  
Patient Reported Outcome ◽  
Self Management ◽  
Semistructured Interview ◽  
Web Based ◽  
Care Continuum ◽  
Patient Reported

PURPOSE Patient-centered digital interventions may help empower young women to self-manage symptoms and psychosocial concerns and support informational needs often unaddressed in clinic. METHODS Young, Empowered and Strong (YES) is an interactive web-based intervention designed to engage young women with personalized education and symptom self-management resources on the basis of responses to patient-reported outcome–based questionnaires. We piloted YES among young women (< 45 years) with newly diagnosed early breast cancer (EBC) or metastatic breast cancer (MBC) and breast cancer survivors (BCSs). Assessments were deployed weekly (EBC and MBC) or every 4 weeks (BCSs) over 12 weeks. At study completion, use, feasibility, and acceptability of YES were evaluated via a survey and semistructured interview. RESULTS Thirty women were enrolled between April and June 2019: 10 EBC, 10 BCSs, and 10 MBC. The mean age at diagnosis and enrollment was 36 (range 25-44) and 39 (range 31-44) years, respectively. Most participants were actively treated (96%, 27 of 28) with endocrine therapy (54%, 15 of 28) or chemotherapy (43%, 12 of 28). Overall, 61% (180 of 296) of assessments were completed (EBC: 70%, BCSs: 63%, and MBC: 52%). Of 37 patient-reported outcome and need domains, the most frequently triggered were sexual health (EBC: 90%, BCSs: 90%, and MBC: 90%), anxiety (EBC: 80%, BCSs: 90%, and MBC: 90%), stress and mindfulness (EBC: 80%, BCSs: 90%, and MBC: 90%), and fatigue (EBC: 90%, BCSs: 80%, and MBC: 90%). On postpilot survey, participants reported that YES helped them to learn (50%, 7 of 14), monitor (43%, 6 of 14), and manage (57%, 8 of 14) their symptoms. CONCLUSION YES is a feasible and acceptable digital intervention to support young women across the breast cancer care continuum. The nearly universal triggering of sexual and mental health needs suggests suboptimal management in the clinical setting and the potential for self-management through a digital platform.

scholarly journals Information and support needs of young women regarding breast cancer risk and genetic testing: adapting effective interventions for a novel population

2017 ◽  
Vol 17 (3) ◽  
pp. 351-360 ◽  
Author(s):  
Suzanne C. O’Neill ◽  
Chalanda Evans ◽  
Rebekah J. Hamilton ◽  
Beth N. Peshkin ◽  
Claudine Isaacs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Testing ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Young Women ◽  
Support Needs ◽  
Effective Interventions

scholarly journals Pathological features and genetic testing among breast cancer young women: a single-institution experience

Mastology ◽  
2018 ◽  
Vol 28 (s1) ◽  
pp. 63-63
Author(s):  
Leandro G. Oliveira ◽  
◽  
Ana C. G. Lima ◽  
Danilo A. Gusmão ◽  
Deidimar C. B. Abreu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Testing ◽  
Young Women ◽  
Pathological Features ◽  
Single Institution

Fertility outcomes in young women with breast cancer: A Web-based survey

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6085-6085
Author(s):  
A. H. Partridge ◽  
S. Gelber ◽  
J. Peppercorn ◽  
E. Sampson ◽  
M. Laufer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Web Based

scholarly journals Outcome of patients with pregnancy during or after breast cancer: a review of the recent literature

2014 ◽  
Vol 22 ◽  
pp. 8 ◽  
Author(s):  
J. Raphael ◽  
M.E. Trudeau ◽  
K. Chan
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Randomized Trials ◽  
Recent Literature ◽  
Stage At Diagnosis ◽  
Control Groups ◽  
Level Of Evidence ◽  
Web Based ◽  
High Level ◽  
Meta Analyses

BackgroundAn increasing number of young women are delaying childbearing; hence, more are diagnosed with breast cancer (bca) before having a family. No clear recommendations are currently available for counselling such a population on the safety of carrying a pregnancy during bca or becoming pregnant after treatment for bca.MethodsUsing a Web-based search of PubMed we reviewed the recent literature about bca and pregnancy. Our objective was to report outcomes for patients diagnosed with bca during pregnancy, comparing them with outcomes for non-pregnant women, and to evaluate prognosis in women diagnosed with and treated for bca who subsequently became pregnant.Results“Pregnancy and bca” should be divided into two entities. Pregnancy-associated bca tends to be more aggressive and advanced in stage at diagnosis than bca in control groups; hence, it has a poorer prognosis. With respect to pregnancy after bca, there is, despite the bias in reported studies and meta-analyses, no clear evidence for a different or worse disease outcome in bca patients who become pregnant after treatment compared with those who do not.ConclusionsPregnancy-associated bca should be treated as aggressively as and according to the standards applicable in nonpregnant women; pregnancy after bca does not jeopardize outcome. The guidelines addressing risks connected to pregnancy and bca lack a high level of evidence for better counselling young women about pregnancy considerations and preventing unnecessary abortions. Ideally, evidence from large prospective randomized trials would set better guidelines, and yet the complexity of such studies limits their feasibility.

Fertility outcomes in young women with breast cancer: A Web-based survey

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6085-6085
Author(s):  
A. H. Partridge ◽  
S. Gelber ◽  
J. Peppercorn ◽  
E. Sampson ◽  
M. Laufer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Young Women ◽  
Web Based

scholarly journals Development of Breast Cancer Choices: a decision support tool for young women with breast cancer deciding whether to have genetic testing for BRCA1/2 mutations

2018 ◽  
Vol 27 (1) ◽  
pp. 297-309 ◽  
Author(s):  
Chloe Grimmett ◽  
Charlotte Brooks ◽  
Alejandra Recio-Saucedo ◽  
Anne Armstrong ◽  
Ramsey I Cutress ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Decision Support ◽  
Genetic Testing ◽  
Young Women ◽  
Decision Support Tool ◽  
Support Tool
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