scholarly journals SHORT-TERM RECOVERY FROM ALCOHOL ABUSE OR DEPENDENCE: ANY EVIDENCE OF A RELATIONSHIP WITH TREATMENT USE IN A GENERAL POPULATION SAMPLE?

2005 ◽  
Vol 40 (5) ◽  
pp. 419-421 ◽  
Author(s):  
JOHN A. CUNNINGHAM
Keyword(s):  
General Population ◽  
Alcohol Abuse ◽  
Population Sample ◽  
General Population Sample ◽  
Short Term ◽  
Treatment Use

scholarly journals Dickkopf-3 (DKK3) in Urine Identifies Patients with Short-Term Risk of eGFR Loss

2018 ◽  
Vol 29 (11) ◽  
pp. 2722-2733 ◽  
Author(s):  
Stephen Zewinger ◽  
Thomas Rauen ◽  
Michael Rudnicki ◽  
Giuseppina Federico ◽  
Martina Wagner ◽  
...  
Keyword(s):  
General Population ◽  
Iga Nephropathy ◽  
Population Sample ◽  
Kidney Injury ◽  
Tubulointerstitial Fibrosis ◽  
General Population Sample ◽  
Short Term ◽  
Creatinine Concentration ◽  
The Individual ◽  
Egfr Decline

BackgroundThe individual course of CKD may vary, and improved methods for identifying which patients will experience short-term eGFR loss are needed. Assessing urinary Dickkopf-3 (DKK3), a stress-induced tubular epithelia–derived profibrotic glycoprotein, may provide information about ongoing tubulointerstitial fibrosis and short-term eGFR loss.MethodsTo investigate urinary DKK3’s potential as a biomarker of short-term eGFR loss (over 12 months), we prospectively assessed eGFR and urinary DKK3 levels in patients with CKD of various etiologies at baseline and annual follow-ups. We also measured urinary DKK3 in a general population sample and patients with diagnostic kidney biopsies or IgA nephropathy under treatment.ResultsMedian urinary DKK3-to-creatinine concentration at baseline was significantly higher in patients with CKD than the general population sample (431 versus 33 pg/mg). In the CKD cohort, having a urinary DKK3-to-creatinine level >4000 pg/mg was independently and significantly associated after multiple adjustments with mean annual decline in eGFR of 7.6% over 12 months. Urinary DKK3 significantly improved prediction of kidney function decline compared with eGFR or albuminuria alone. Urinary DKK3-to-creatinine levels were related to the extent of tubulointerstitial fibrosis in kidney biopsies. In patients with IgA nephropathy, a rise in urinary DKK3 was associated with significant eGFR decline within 6 months, whereas stable or decreasing urinary DKK3 indicated a more favorable course.ConclusionsUrinary DKK3 levels identify patients at high risk for eGFR decline over the next 12 months regardless of the cause of kidney injury and beyond established biomarkers, potentially providing a tool to monitor CKD progression and assess effects of interventions.

scholarly journals The association between short‐term residential black carbon concentration on blood pressure in a general population sample

Indoor Air ◽  
2020 ◽  
Vol 30 (4) ◽  
pp. 767-775 ◽  
Author(s):  
Felicia A. Rabito ◽  
Qiang Yang ◽  
Hao Zhang ◽  
Derek Werthmann ◽  
Arti Shankar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
General Population ◽  
Black Carbon ◽  
Carbon Concentration ◽  
Population Sample ◽  
General Population Sample ◽  
Short Term ◽  
Black Carbon Concentration

scholarly journals Short-term changes in substance use among problematic alcohol and drug users from a general population sample

2014 ◽  
Vol 3 (4) ◽  
pp. 277-287 ◽  
Author(s):  
Kristina Sinadinovic ◽  
Peter Wennberg ◽  
Anne H. Berman
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
General Population ◽  
Drug Users ◽  
Population Sample ◽  
General Population Sample ◽  
Short Term ◽  
Problematic Use ◽  
Problematic Alcohol

Sinadinovic, K., Wennberg, P., & Berman, A. (2014). Short-term changes in substance use among problematic alcohol and drug users from a general population sample. The International Journal Of Alcohol And Drug Research, 3(4), 277-287. doi:http://dx.doi.org/10.7895/ijadr.v3i4.186Aims: To investigate 12-month changes among individuals with baseline problematic use of alcohol or illicit drugs, by gender, age, initial level of substance use, and administration method (Internet or Interactive Voice Response, IVR).Design: 1,861 individuals from a random population sample were screened for problematic alcohol and illicit drug use. Individuals screening positive were followed up after 12 months.Setting: The Swedish general population.Participants: 423 individuals with baseline problematic alcohol (women: AUDIT ≥ 6, men: AUDIT ≥ 8) or drug use (both genders: DUDIT ≥ 1).Measures: AUDIT, DUDIT, AUDIT-C and DUDIT-C scores.Findings: AUDIT scores decreased from 10.43 to 8.62; among 239 participants with baseline problematic alcohol use, 34.3% no longer had problematic use at follow-up. Total DUDIT scores decreased from 4.92 to 2.33; among 51 participants with baseline problematic drug use, 60.8% reported no illicit drug use at follow-up. AUDIT and DUDIT scores decreased more for individuals who at baseline had harmful problematic use, compared to those who had hazardous baseline use. Within-group effect sizes for AUDIT and DUDIT scores varied between 0.29 and 0.69 (Cohen’s d).Conclusions: Data on short-term change in problematic substance use in a random general population sample could constitute a reference point for comparisons for uncontrolled treatment studies.

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