scholarly journals Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of US Military Personnel

2013 ◽  
Vol 177 (5) ◽  
pp. 411-419 ◽  
Author(s):  
K. L. Munger ◽  
L. I. Levin ◽  
J. Massa ◽  
R. Horst ◽  
T. Orban ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Military Personnel ◽  
Hydroxyvitamin D ◽  
Us Military ◽  
25 Hydroxyvitamin D

scholarly journals Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4260
Author(s):  
Liana Najjar ◽  
Joshua Sutherland ◽  
Ang Zhou ◽  
Elina Hyppönen
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Low Frequency ◽  
Nucleotide Polymorphisms ◽  
Hydroxyvitamin D ◽  
Quantitative Synthesis ◽  
25 Hydroxyvitamin D

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords “vitamin D” and/or “single nucleotide polymorphisms (SNPs)” and “T1D” were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97–1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

scholarly journals An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children

2014 ◽  
Vol 99 (11) ◽  
pp. E2353-E2356 ◽  
Author(s):  
Marjaana Mäkinen ◽  
Ville Simell ◽  
Juha Mykkänen ◽  
Jorma Ilonen ◽  
Riitta Veijola ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetes Incidence ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Maternal Level of 25-Hydroxyvitamin D during Pregnancy Associated with Risk of Type 1 Diabetes in the Offspring, a Meta-Analysis

2020 ◽  
Vol 66 (5) ◽  
pp. 402-408
Author(s):  
Xinyi KANG ◽  
Jiawen CUI ◽  
Mingjin ZHANG ◽  
Ying WANG ◽  
Weichun TANG ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Meta Analysis ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Genetic determinants of serum 25-hydroxyvitamin D concentration during pregnancy and type 1 diabetes in the child

PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0184942 ◽  
Author(s):  
Maija E. Miettinen ◽  
Melissa C. Smart ◽  
Leena Kinnunen ◽  
Valma Harjutsalo ◽  
Linnea Reinert-Hartwall ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Determinants ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

scholarly journals Vitamin D-binding protein and 25-hydroxyvitamin D during pregnancy in mothers whose children later developed type 1 diabetes

2016 ◽  
Vol 32 (8) ◽  
pp. 883-890 ◽  
Author(s):  
Ingvild M. Sørensen ◽  
Geir Joner ◽  
Pål A. Jenum ◽  
Anne Eskild ◽  
Cathrine Brunborg ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D
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