scholarly journals Endometrial Cancer Risk Factors by 2 Main Histologic Subtypes

2012 ◽  
Vol 177 (2) ◽  
pp. 142-151 ◽  
Author(s):  
Hannah P. Yang ◽  
Nicolas Wentzensen ◽  
Britton Trabert ◽  
Gretchen L. Gierach ◽  
Ashley S. Felix ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Histologic Subtypes

scholarly journals Multi-trait genome-wide association study identifies novel endometrial cancer risk loci that are associated with obesity or female testosterone levels

2021 ◽  
Author(s):  
Xuemin Wang ◽  
Pik Fang Kho ◽  
Dhanya Ramachandran ◽  
Cemsel Bafligil ◽  
Frederic Amant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Genome Wide

We have performed genetic correlation and Mendelian randomization analyses using publicly available genome-wide association study (GWAS) data to identify endometrial cancer risk factors. These and previously established risk factors of endometrial cancer were then included in a multi-trait Bayesian GWAS analysis to detect endometrial cancer susceptibility variants, identifying three novel loci (7q22.1, 8q24.3 and 16q12.2); two of which were replicated in an independent endometrial cancer GWAS dataset. These loci are hypothesized to affect endometrial cancer risk through altered sex-hormone levels or through effects on obesity. Consistent with this hypothesis, several genes with established roles in these pathways (CYP11B1, CYP3A7, IRX3 and IRX5) were prioritized as candidate endometrial cancer risk genes by interrogation of quantitative trait loci data and chromatin capture assays in endometrial cell lines. The findings of this study identify additional opportunities for hormone treatment and further support weight loss to reduce the risk of developing endometrial cancer.

A survey of patient knowledge on contraception and endometrial cancer risk factors

2020 ◽  
Vol 159 ◽  
pp. 238-239
Author(s):  
S. Patel ◽  
O.D. Lara ◽  
R. Tsai ◽  
M.Y. Williams-Brown
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Patient Knowledge ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors

Knowledge of endometrial cancer risk factors in a general gynecologic population

2020 ◽  
Vol 158 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Christina R. Washington ◽  
Ashley Haggerty ◽  
Wanda Ronner ◽  
Pamela M. Neff ◽  
Emily M. Ko
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors

scholarly journals Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors

2016 ◽  
Vol 27 (6) ◽  
pp. 737-748 ◽  
Author(s):  
Melissa A. Merritt ◽  
Howard D. Strickler ◽  
Mark H. Einstein ◽  
Hannah P. Yang ◽  
Mark E. Sherman ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Sex Hormone ◽  
Human Endometrium ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors

Knowledge of Endometrial Cancer Risk Factors in a General Gynecologic Population

2020 ◽  
Vol 75 (10) ◽  
pp. 604-605
Author(s):  
Christina R. Washington ◽  
Ashley Haggerty ◽  
Wanda Ronner ◽  
Pamela M. Neff ◽  
Emily M. Ko
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors

scholarly journals MON-LB004 Understanding the Influence of Endometrial Cancer Risk Factors Using Human Primary Endometrial Organoids

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Alina R Murphy ◽  
Hannes Campo ◽  
Julie Kim
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Real Time ◽  
High Serum ◽  
Protective Effects ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Increased Risk ◽  
Real Time Qpcr

Abstract It is unclear how endometrial cancer risk factors such as obesity, high serum testosterone, and high serum levels of the endocrine-disrupting compound bisphenol-A (BPA) influence hormone action to promote carcinogenesis. We hypothesized that obesity, high testosterone, and BPA exposure alters the protective progesterone response in the benign endometrium. Primary human benign endometrial organoids, consisting of both epithelial and stromal cells, were exposed to each of these risk factors in vitro in the presence of cyclic levels of estradiol, progesterone, and testosterone for 14 days. Progesterone response genes HSD17B2, IGFBP1, PAEP, and PRL were measured by real-time qPCR and IHC. First, to simulate obesity, endometrial organoids were cocultured with increasing numbers of human adipocyte spheroids during the hormone treatment. Real-time qPCR analysis revealed dysregulation of expression of HSD17B2 and IGFBP1 by approximately 20% when cocultured with 30 adipocyte spheroids. In addition, PRL protein levels were significantly lower in the stroma of the endometrial organoids. Second, increasing concentrations of BPA and 3nM testosterone individually or in combination were added to endometrial organoids together with the 14-day menstrual cycle hormones. Treatment with 0.6 ng/mL of BPA decreased expression of HSD17B2, IGFBP1, and PAEP by 50% to 80%. However, this effect was not seen in the context of high testosterone, indicating that there may be crosstalk between these two risk factors. In summary, this study demonstrated that adipocytes, BPA exposure, and high testosterone directly alter progesterone action in benign endometrial organoids, suggesting a diminution of the protective effects of progesterone and an increased risk of endometrial cancer.

scholarly journals Endometrial cancer risk factors among Lynch syndrome women: a retrospective cohort study

2016 ◽  
Vol 115 (3) ◽  
pp. 375-381 ◽  
Author(s):  
Synnöve Staff ◽  
Mari Aaltonen ◽  
Heini Huhtala ◽  
Kirsi Pylvänäinen ◽  
Jukka-Pekka Mecklin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Lynch Syndrome ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors
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