scholarly journals Arsenic Exposure, Diabetes Prevalence, and Diabetes Control in the Strong Heart Study

2012 ◽  
Vol 176 (10) ◽  
pp. 865-874 ◽  
Author(s):  
M. O. Gribble ◽  
B. V. Howard ◽  
J. G. Umans ◽  
N. M. Shara ◽  
K. A. Francesconi ◽  
...  
Keyword(s):  
Arsenic Exposure ◽  
Diabetes Control ◽  
Diabetes Prevalence ◽  
Strong Heart Study ◽  
Heart Study

Abstract P044: Urine Arsenic Concentrations and Glycated Hemoglobin: Associations by Diabetes Status in the Strong Heart Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Matthew O Gribble ◽  
Barbara V Howard ◽  
Jason G Umans ◽  
Nawar Shara ◽  
Kevin A Francesconi ◽  
...  
Keyword(s):  
Fasting Glucose ◽  
Arsenic Exposure ◽  
Inorganic Arsenic ◽  
Diabetes Control ◽  
Diabetes Treatment ◽  
Strong Heart Study ◽  
Urine Creatinine ◽  
Heart Study ◽  
Diabetes Status ◽  
Hba1c Levels

Introduction: Low-moderate exposure to inorganic arsenic has been associated with hemoglobin A1c (HbA1c) in some studies. While HbA1c is a marker of diabetes control among individuals with treated diabetes, the association between arsenic and HbA1c has not been evaluated according to diabetes status. Hypothesis: Arsenic is positively associated with HbA1c. Methods: We included 3,567 (1774 with diabetes and 1793 without diabetes) American Indian adults who participated in the Strong Heart Study in 1989-1991 with measured urine arsenic, HbA1c and other covariates. We compared HbA1c levels by urine arsenic quartiles using linear regression stratified by diabetes status and adjusted for urine creatinine, demographic variables, body mass index and smoking. Among diabetics, we ran models stratified by fasting glucose and by diabetes treatment. Results: Median (interquartile range) HbA1c levels were 8.1 (6.1, 10.3)% and 5.1 (4.7, 5.4)%, in participants with and without diabetes, respectively. Adjusted mean HbA1c levels were 0.55 (95% CI 0.20, 0.90)%, 1.13 (0.76, 1.49)% and 1.28 (0.77, 1.59)% higher in quartiles 2-4 compared to the lowest quartile; p for trend <0.001. Urine arsenic was not associated with HbA1c levels in those without diabetes: mean difference in HbA1c levels comparing quartiles 2-4 to the lowest quartile were 0.08 (0.01, 0.15)%, -0.03 (-0.10, 0.05)% and -0.05 (-0.13, 0.04)%, respectively; p for trend =0.10. Among diabetics, the association between arsenic and HbA1c was strongest among participants with fasting glucose ≥180 mg/dL, in untreated participants, and in those taking only oral hypoglycemics (Table). Difference (95% Confidence Interval) in HbA1c by Total Urine Arsenic (adjusted for age, sex, region, obesity, smoking and urine creatinine) Fasting Plasma Glucose (mg/dL) Diabetes Treatment Urine Arsenic (μg/L) <1.6 (N=291) ≥126 and <180 (N=594) ≥180(N=865) None (N=688) Oral(N=637) Insulin (N=436) Q1 (<8.83) 0.00 (referent) 0.00 (referent) 0.00 (referent) 0.00 (referent) 0.00 (referent) 0.00 (referent) Q2 (≥8.83 and <15.38) 0.15 (-0.33,0.64) 0.04 (-0.34, 0.42) 0.41 (0.03, 0.80) 0.57 (0.07, 1.06) 0.37 (-0.15, 0.89) 0.35 (-0.27, 0.97) Q3 (≥15.38 and <26.37) 0.43 (-0.12, 0.98) 0.38 (-0.04, 0.80) 0.49 (0.09, 0.90) 0.93 (0.39, 1.46) 0.73 (0.19, 1.28) 0.61 (-0.07, 1.28) Q4(≥26.37) −0.21 (-0.86, 0.44) 0.27 (-0.17, 0.71) 0.58 (0.12, 1.04) 0.91 (0.34, 1.49) 0.90 (0.25, 1.54) 0.36 (-0.38, 1.11) p for trend * 0.29 0.22 0.08 0.02 0.01 0.69 * Based on quartile medians Urine arsenic concentrations were positively associated with HbA1c in Strong Heart Study participants with diabetes. No association was found among participants without diabetes. Prospective analyses that evaluate the relationship between arsenic exposure and diabetes, including measures of diabetes control, are needed.

scholarly journals Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study

Diabetes Care ◽  
2015 ◽  
pp. dc141641 ◽  
Author(s):  
Chin-Chi Kuo ◽  
Barbara V. Howard ◽  
Jason G. Umans ◽  
Matthew O. Gribble ◽  
Lyle G. Best ◽  
...  
Keyword(s):  
Arsenic Exposure ◽  
Incident Diabetes ◽  
Arsenic Metabolism ◽  
Strong Heart Study ◽  
Heart Study

Low-Moderate Arsenic Exposure and QT Interval: the Strong Heart Study

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Katherine A Moon* ◽  
Peter Okin ◽  
Richard Devereux ◽  
Eliseo Guallar ◽  
Jason G Umans ◽  
...  
Keyword(s):  
Qt Interval ◽  
Arsenic Exposure ◽  
Strong Heart Study ◽  
Heart Study

scholarly journals Arsenic Exposure and Cancer Mortality in a US-Based Prospective Cohort: The Strong Heart Study

2013 ◽  
Vol 22 (11) ◽  
pp. 1944-1953 ◽  
Author(s):  
Esther García-Esquinas ◽  
Marina Pollán ◽  
Jason G. Umans ◽  
Kevin A. Francesconi ◽  
Walter Goessler ◽  
...  
Keyword(s):  
Cancer Mortality ◽  
Prospective Cohort ◽  
Arsenic Exposure ◽  
Strong Heart Study ◽  
Heart Study

scholarly journals Arsenic metabolism and one-carbon metabolism at low-moderate arsenic exposure: Evidence from the Strong Heart Study

2017 ◽  
Vol 105 ◽  
pp. 387-397 ◽  
Author(s):  
Miranda Jones Spratlen ◽  
Mary V. Gamble ◽  
Maria Grau-Perez ◽  
Chin-Chi Kuo ◽  
Lyle G. Best ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Arsenic Exposure ◽  
Arsenic Metabolism ◽  
Strong Heart Study ◽  
Heart Study ◽  
One Carbon Metabolism

scholarly journals Arsenic Metabolism and One-Carbon Metabolism at Low-Moderate Arsenic Exposure: Evidence from the Strong Heart Study

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Miranda Spratlen* ◽  
Chin-Chi Kuo ◽  
Maria Grau ◽  
Lyle Best ◽  
Joseph Yracheta ◽  
...  
Keyword(s):  
Carbon Metabolism ◽  
Arsenic Exposure ◽  
Arsenic Metabolism ◽  
Strong Heart Study ◽  
Heart Study ◽  
One Carbon Metabolism

Low to Moderate Arsenic Exposure and Incident Cardiovascular Disease: The Strong Heart Study

2013 ◽  
Vol 2013 (1) ◽  
pp. 5375
Author(s):  
Katherine Moon ◽  
Eliseo Guallar ◽  
Jason G. Umans ◽  
Richard B. Devereux ◽  
Lyle Best ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Arsenic Exposure ◽  
Strong Heart Study ◽  
Heart Study ◽  
Incident Cardiovascular Disease

scholarly journals Low-moderate arsenic exposure and respiratory in American Indian communities in the Strong Heart Study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Martha Powers ◽  
Tiffany R. Sanchez ◽  
Maria Grau-Perez ◽  
Fawn Yeh ◽  
Kevin A. Francesconi ◽  
...  
Keyword(s):  
Drinking Water ◽  
Lung Function ◽  
Lung Disease ◽  
American Indian ◽  
Arsenic Exposure ◽  
Airflow Obstruction ◽  
Strong Heart Study ◽  
Heart Study ◽  
Lower Lung ◽  
Restrictive Pattern

Abstract Background Arsenic exposure through drinking water is an established lung carcinogen. Evidence on non-malignant lung outcomes is less conclusive and suggests arsenic is associated with lower lung function. Studies examining low-moderate arsenic (< 50 μg/L), the level relevant for most populations, are limited. We evaluated the association of arsenic exposure with respiratory health in American Indians from the Northern Plains, the Southern Plains and the Southwest United States, communities with environmental exposure to inorganic arsenic through drinking water. Methods The Strong Heart Study is a prospective study of American Indian adults. This analysis used urinary arsenic measurements at baseline (1989–1991) and spirometry at Visit 2 (1993–1995) from 2132 participants to evaluate associations of arsenic exposure with airflow obstruction, restrictive pattern, self-reported respiratory disease, and symptoms. Results Airflow obstruction was present in 21.5% and restrictive pattern was present in 14.4%. The odds ratio (95% confidence interval) for obstruction and restrictive patterns, based on the fixed ratio definition, comparing the 75th to 25th percentile of arsenic, was 1.17 (0.99, 1.38) and 1.27 (1.01, 1.60), respectively, after adjustments, and 1.28 (1.02, 1.60) and 1.33 (0.90, 1.50), respectively, based on the lower limit of normal definition. Arsenic was associated with lower percent predicted FEV1 and FVC, self-reported emphysema and stopping for breath. Conclusion Low-moderate arsenic exposure was positively associated with restrictive pattern, airflow obstruction, lower lung function, self-reported emphysema and stopping for breath, independent of smoking and other lung disease risk factors. Findings suggest that low-moderate arsenic exposure may contribute to restrictive lung disease.

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