scholarly journals Modification of the Association Between Ambient Air Pollution and Lung Function by Frailty Status Among Older Adults in the Cardiovascular Health Study

2012 ◽  
Vol 176 (3) ◽  
pp. 214-223 ◽  
Author(s):  
Sandrah P. Eckel ◽  
Thomas A. Louis ◽  
Paulo H. M. Chaves ◽  
Linda P. Fried, ◽  
and Helene G. Margolis
Keyword(s):  
Older Adults ◽  
Air Pollution ◽  
Lung Function ◽  
Cardiovascular Health ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Frailty Status

Abstract MP57: Associations of Pentraxin 3 with Frailty: The Cardiovascular Health Study (CHS)

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Nancy S Jenny ◽  
Alice M Arnold ◽  
Lewis H Kuller ◽  
Jeremy D Walston ◽  
Russell P Tracy ◽  
...  
Keyword(s):  
Older Adults ◽  
Healthy Aging ◽  
Cardiovascular Health ◽  
Robust Regression ◽  
Vascular Damage ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Pentraxin 3 ◽  
Inflammatory Biomarker ◽  
Frailty Status

Background: Pentraxin 3 (PTX3) is an inflammatory biomarker primarily reflecting vascular damage. PTX3 is associated with cardiovascular disease (CVD); however, associations with frailty, another inflammation-related disease of aging, are unknown. Methods: At baseline, we examined these associations in 1,948 white and black men and women (mean age 73 y) in the Cardiovascular Health Study (CHS) who had measures of PTX3 and were free of dementia, Parkinson’s disease and depression. PTX3 was determined by immunoassay (coefficient of variation 10%). Robust regression models were minimally adjusted for age, sex, ethnicity and clinic site with additional adjustments for obesity, smoking, education, C-reactive protein (CRP) and prevalent subclinical or clinical CVD. Results: Levels of PTX3 ranged from 0.24 - 23.05 ng/ml, mean 2.36 ng/ml (standard deviation 2.00 ng/ml), in these older adults. PTX3 was significantly associated with unintentional weight loss (p<0.001), slow walk time (p=0.04) and low grip strength (p=0.03), but not the other domains of frailty, exhaustion and physical activity, both p>0.2. Increased PTX3 was also associated with frailty status comparing those who were not frail (0 domains of frailty, N=879) to those who were intermediate frail (presence of 1-2 domains of frailty, N=926) or frail (≥3 domains, N=143). In minimally adjusted models, the relative risk (RR) for intermediate frailty was 1.22 (95% confidence interval 1.04-1.44) and 1.70 (1.25-2.29) for prevalent frailty, comparing both to non-frail. Results were slightly attenuated but remained significant in fully adjusted models; RR 1.19 (1.01-1.41) for intermediate and 1.59 (1.16-2.18) for frail. As some biomarkers show sex-dependent associations, we stratified on sex. In fully adjusted models, increased PTX3 was associated with intermediate frailty (RR 1.3; 1.00-1.69) and frailty (RR 2.14; 1.24-3.67) in men, but did not appear to be associated in women (RR 1.13; 0.91-1.42 for intermediate and 1.28; 0.85-1.92 for frail); however, the interaction term was not significant (p=0.2). Conclusions: In these older adults, PTX3 was associated with some domains of frailty and frailty status. Associations were independent of the presence of clinical and/or subclinical CVD and CRP, a biomarker of general inflammation. PTX3 may reflect ongoing vascular damage in multiple aging-related diseases such as CVD and frailty. Further study is needed to evaluate the potential for PTX3 to act as a biomarker of healthy aging.

scholarly journals Frailty and driving status associated with disability: a 24-month follow-up longitudinal study

BMJ Open ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. e042468
Author(s):  
Takehiko Doi ◽  
Kota Tsutsumimoto ◽  
Hideaki Ishii ◽  
Sho Nakakubo ◽  
Satoshi Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Cardiovascular Health ◽  
Community Setting ◽  
Community Dwelling ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
Term Care ◽  
Frailty Status ◽  
A Prospective Study

ObjectivesTo examine the relationship of driving status and frailty with disability in older adults.DesignA prospective study.Setting and participantsThe study included 8533 participants (mean age: 72.0±6.1 years (range: 60–98 years), women: 54.1%) in a community setting.MeasuresDriving status and frailty were assessed at baseline. The clinical definition of frailty was used according to the Japanese Cardiovascular Health Study index. Disability was prospectively determined using a record of Japanese long-term care insurance (LTCI).ResultsDuring the follow-up period (mean duration: 23.5 months), 58 (0.7%) participants were regarded as moving out of the city, 80 (0.9%) participants had died and 311 (3.6%) participants were certified by LTCI. The proportion of disability was 1.3% among the not-frail group and 5.3% among the frail group. The proportion of disability was 2.5% in participants who were currently driving and 7.5% in those not driving. Based on frailty status and driving, participants were further classified into four groups: not frail and currently driving (n=2945), not frail and not driving (n=642), frail and currently driving (n=3598) and frail and not driving (n=1348). Compared with older adults who are not frail and driving, the combined status of frail and not driving (adjusted HR: 2.28; 95% CI: 1.47 to 3.52) and frail and driving (HR: 1.91; 95% CI: 1.30–2.81) were risk factors for disability.ConclusionsNot driving and frail were associated with a risk of disability in community-dwelling older adults.

scholarly journals Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group.

Hypertension ◽  
1992 ◽  
Vol 19 (6_pt_1) ◽  
pp. 508-519 ◽  
Author(s):  
G H Rutan ◽  
B Hermanson ◽  
D E Bild ◽  
S J Kittner ◽  
F LaBaw ◽  
...  
Keyword(s):  
Older Adults ◽  
Orthostatic Hypotension ◽  
Research Group ◽  
Collaborative Research ◽  
Cardiovascular Health ◽  
Health Study ◽  
Cardiovascular Health Study

The Global Threat of Outdoor Ambient Air Pollution to Cardiovascular Health

2017 ◽  
Vol 2 (4) ◽  
pp. 353 ◽  
Author(s):  
Robert D. Brook ◽  
David E. Newby ◽  
Sanjay Rajagopalan
Keyword(s):  
Air Pollution ◽  
Cardiovascular Health ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Global Threat
Sign in / Sign up

Export Citation Format

Share Document