scholarly journals Maternal Effects for Preterm Birth: A Genetic Epidemiologic Study of 630,000 Families

2009 ◽  
Vol 170 (11) ◽  
pp. 1365-1372 ◽  
Author(s):  
Anna C. Svensson ◽  
Sven Sandin ◽  
Sven Cnattingius ◽  
Marie Reilly ◽  
Yudi Pawitan ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Maternal Effects ◽  
Epidemiologic Study ◽  
Genetic Epidemiologic Study

scholarly journals A Genetic Epidemiologic Study of Candidate Genes Involved in the Optic Nerve Head Morphology

2012 ◽  
Vol 53 (3) ◽  
pp. 1485 ◽  
Author(s):  
Andrea C. Gasten ◽  
Wishal D. Ramdas ◽  
Linda Broer ◽  
Leonieke M. E. van Koolwijk ◽  
M. Kamran Ikram ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Candidate Genes ◽  
Optic Nerve Head ◽  
Epidemiologic Study ◽  
Head Morphology ◽  
Genetic Epidemiologic Study

A genetic epidemiologic study of self-report suspiciousness

1987 ◽  
Vol 28 (3) ◽  
pp. 187-196 ◽  
Author(s):  
Kenneth S. Kendler ◽  
Andrew Heath ◽  
Nicholas G. Martin
Keyword(s):  
Epidemiologic Study ◽  
Self Report ◽  
Genetic Epidemiologic Study

Genetic epidemiologic study of hearing loss in an adult population

1994 ◽  
Vol 54 (2) ◽  
pp. 149-153 ◽  
Author(s):  
Anne M. Sill ◽  
Melissa J. Stick ◽  
Valerie L. Prenger ◽  
Susan L. Phillips ◽  
Joann A. Boughman ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Adult Population ◽  
Epidemiologic Study ◽  
Genetic Epidemiologic Study

Genetic-epidemiologic study of omphalocele and gastroschisis: Evidence for heterogeneity

1992 ◽  
Vol 44 (5) ◽  
pp. 668-675 ◽  
Author(s):  
Ping Yang ◽  
Terri H. Beaty ◽  
Muin J. Khoury ◽  
Elsbeth Chee ◽  
Walter Stewart ◽  
...  
Keyword(s):  
Epidemiologic Study ◽  
Genetic Epidemiologic Study

scholarly journals Cohort Profile: ZOE 2.0—A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health

2020 ◽  
Vol 17 (21) ◽  
pp. 8056
Author(s):  
Kimon Divaris ◽  
Gary D. Slade ◽  
Andrea G. Ferreira Zandona ◽  
John S. Preisser ◽  
Jeannie Ginnis ◽  
...  
Keyword(s):  
Early Childhood ◽  
Oral Health ◽  
Genome Wide Association Study ◽  
Epidemiologic Study ◽  
Community Based ◽  
Cross Sectional ◽  
Genome Wide ◽  
Rich Data ◽  
Racial Ethnic ◽  
Genetic Epidemiologic Study

Early childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (n = 3872) were African American, 22% white, and 20% (n = 1611) were Hispanic/Latino. Seventy-nine percent (n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.

A powerful test for ordinal trait genetic association analysis

2019 ◽  
Vol 18 (2) ◽  
Author(s):  
Yuan Xue ◽  
Jinjuan Wang ◽  
Juan Ding ◽  
Sanguo Zhang ◽  
Qizhai Li
Keyword(s):  
Complex Disease ◽  
Type I Error ◽  
Epidemiologic Study ◽  
Genetic Effect ◽  
Wald Test ◽  
Type I ◽  
New Association ◽  
Citrullinated Protein ◽  
Human Complex ◽  
Genetic Epidemiologic Study

Abstract Response selective sampling design is commonly adopted in genetic epidemiologic study because it can substantially reduce time cost and increase power of identifying deleterious genetic variants predispose to human complex disease comparing with prospective design. The proportional odds model (POM) can be used to fit data obtained by this design. Unlike the logistic regression model, the estimated genetic effect based on POM by taking data as being enrolled prospectively is inconsistent. So the power of resulted Wald test is not satisfactory. The modified POM is suitable to fit this type of data, however, the corresponding Wald test is not optimal when the genetic effect is small. Here, we propose a new association test to handle this issue. Simulation studies show that the proposed test can control the type I error rate correctly and is more powerful than two existing methods. Finally, we applied three tests to Anticyclic Citrullinated Protein Antibody data from Genetic Workshop 16.

Database of Families with Twins and Higher Order Multiples in Japanese Twins Mothers Clubs

2019 ◽  
Vol 22 (6) ◽  
pp. 588-590
Author(s):  
Syuichi Ooki
Keyword(s):  
Response Rate ◽  
Scientific Evidence ◽  
Epidemiologic Study ◽  
Long Term Effect ◽  
Mother And Child Health ◽  
Mother And Child ◽  
Health And Disease ◽  
And Child Health ◽  
Genetic Epidemiologic Study

AbstractIt is desirable for twin researchers to be aware of the needs and concerns of families of multiples and provide participants with appropriate and useful feedback and advice based on scientific evidence. Our most recent database on families with twins throughout Japan is based on a questionnaire survey conducted in 2016. Mailed questionnaires, consisting of over 500 items, were used to collect the basic data. The response rate was 38% (566/1478). This is part of a nationwide study designed to assess the long-term effect of perinatal conditions on mothers of multiples. Its aim was to study the growth and development of multiples in childhood, and for the creation of a multifetal mother and child health handbook, and to conduct a genetic epidemiologic study to test the developmental origin of health and disease hypothesis. One of the ultimate aims of this research was to provide evidence-based information on parenting of multiples for families with multiples.

Evaluation of potential sources of bias in a genetic epidemiologic study of breast cancer

1997 ◽  
Vol 14 (1) ◽  
pp. 85-95 ◽  
Author(s):  
Lorna M. Seybolt ◽  
Celine Vachon ◽  
Karen Potter ◽  
Wei Zheng ◽  
Lawrence H. Kushi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epidemiologic Study ◽  
Potential Sources ◽  
Genetic Epidemiologic Study
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