scholarly journals Association of Selective and Conventional Nonsteroidal Antiinflammatory Drugs with Acute Renal Failure: A Population-based, Nested Case-Control Analysis

2006 ◽  
Vol 164 (9) ◽  
pp. 881-889 ◽  
Author(s):  
Verena Schneider ◽  
Linda E. Lévesque ◽  
Bin Zhang ◽  
Thomas Hutchinson ◽  
James M. Brophy
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Population Based ◽  
Case Control ◽  
Nonsteroidal Antiinflammatory Drugs ◽  
Control Analysis ◽  
Antiinflammatory Drugs ◽  
Case Control Analysis ◽  
Nested Case Control

scholarly journals Seizures in patients with Alzheimer’s disease or vascular dementia: A population-based nested case-control analysis

Epilepsia ◽  
2012 ◽  
Vol 54 (4) ◽  
pp. 700-707 ◽  
Author(s):  
Patrick Imfeld ◽  
Michael Bodmer ◽  
Markus Schuerch ◽  
Susan S. Jick ◽  
Christoph R. Meier
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Population Based ◽  
Case Control ◽  
Control Analysis ◽  
Case Control Analysis ◽  
Nested Case Control

Population-Based Study on the Epidemiology of Ménière's Disease

2017 ◽  
Vol 22 (2) ◽  
pp. 74-82 ◽  
Author(s):  
Saskia G. Bruderer ◽  
Daniel Bodmer ◽  
Nadja A. Stohler ◽  
Susan S. Jick ◽  
Christoph R. Meier
Keyword(s):  
Population Based ◽  
Case Control ◽  
Meniere’S Disease ◽  
Ménière’S Disease ◽  
Control Analysis ◽  
Menière's Disease ◽  
Ménière's Disease ◽  
The Uk ◽  
Case Control Analysis ◽  
Nested Case Control

Background and Objective: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. Study Design: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink. Methods: We identified patients between 18 and 79 years of age with an incident MD diagnosis between January 1993 and December 2014. We assessed the IRs of betahistine-treated MD. In the nested case-control analysis, we matched 4 controls to each MD case on sex, age, general practice, years of active history in the database, and calendar time. We conducted a χ2 test to present p values in order to compare the prevalence of demographics, comorbidities, and co-medication between cases and controls. Results: We identified 5,508 MD cases and 22,032 MD-free controls (65.4% females). The overall IR for MD in the UK was 13.1 per 100,000 person-years. More cases were female, and the mean age at diagnosis was 55.4 ± 13.7 years. Smoking and alcohol consumption were less prevalent among MD cases. Depression, other affective disorders, sleeping disorders, anxiety, and migraine were more prevalent among MD cases than among controls. Conclusions: MD is uncommon in primary care in the UK with a preponderance among females.

scholarly journals Risk of hand osteoarthritis in new users of hormone replacement therapy: A nested case-control analysis

Maturitas ◽  
2020 ◽  
Vol 132 ◽  
pp. 17-23
Author(s):  
Theresa Burkard ◽  
Marlene Rauch ◽  
Julia Spoendlin ◽  
Daniel Prieto-Alhambra ◽  
Susan S. Jick ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Case Control ◽  
Hand Osteoarthritis ◽  
Control Analysis ◽  
Case Control Analysis ◽  
Nested Case Control

scholarly journals Discontinuation of oral anticoagulation in atrial fibrillation and risk of ischaemic stroke

Heart ◽  
2020 ◽  
pp. heartjnl-2020-317887
Author(s):  
Luis Alberto García Rodríguez ◽  
Lucía Cea Soriano ◽  
Stine Munk Hald ◽  
Jesper Hallas ◽  
Yanina Balabanova ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischaemic Stroke ◽  
Vitamin K ◽  
Oral Anticoagulant ◽  
Population Based ◽  
Vitamin K Antagonist ◽  
Control Analysis ◽  
The Uk ◽  
Case Control Analysis ◽  
Nested Case Control

ObjectiveTo evaluate associations between oral anticoagulant (OAC) discontinuation and risk of ischaemic stroke (IS) among patients with atrial fibrillation (AF).MethodsWe undertook a population-based cohort study with nested case–control analysis using UK primary care electronic health records (IQVIA Medical Research Data-UK) and linked registries from the Region of Southern Denmark (RSD). Patients with AF (76 882 UK, 41 526 RSD) were followed to identify incident IS cases during 2016–2018. Incident IS cases were matched by age and sex to controls. Adjusted ORs for OAC discontinuation (vs current OAC use) were calculated using logistic regression.ResultsWe identified 616 incident IS cases in the UK and 643 in the RSD. ORs for IS with any OAC discontinuation were 2.99 (95% CI 2.31 to 3.86, UK) and 2.30 (95% CI 1.79 to 2.95, RSD), for vitamin K antagonist discontinuation they were 2.38 (95% CI 1.72 to 3.30, UK) and 1.83 (95% CI 1.34 to 2.49, RSD), and for non-vitamin K antagonist oral anticoagulant discontinuation they were 4.59 (95% CI 2.97 to 7.08, UK) and 3.37 (95% CI 2.35 to 4.85, RSD). ORs were unaffected by time since discontinuation and duration of use. Annually, up to 987 IS cases in the UK and 132 in Denmark could be preventable if OAC therapy is not discontinued.ConclusionsOur results suggest that patients with AF who discontinue OAC therapy have a significant twofold to threefold higher risk of IS compared with those who continue therapy. Addressing OAC discontinuation could potentially result in a significant reduction in AF-attributed IS.

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