scholarly journals Ischaemic stroke or TIA in older subjects associated with impaired dynamic blood pressure control in the absence of severe large artery stenosis

2015 ◽  
Vol 44 (4) ◽  
pp. 655-661 ◽  
Author(s):  
D. J. Ryan ◽  
R. A. Kenny ◽  
S. Christensen ◽  
J. F. M. Meaney ◽  
A. J. Fagan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ischaemic Stroke ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Artery Stenosis ◽  
Large Artery ◽  
Older Subjects

Post-Transplant Renal Artery Stenosis: Impact of Therapy on Long-Term Kidney Function and Blood Pressure Control

1996 ◽  
Vol 155 (6) ◽  
pp. 1860-1864 ◽  
Author(s):  
Bashir R. Sankari ◽  
Michael Geisinger ◽  
Margaret Zelch ◽  
Ben Brouhard ◽  
Robert Cunningham ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Artery ◽  
Renal Artery Stenosis ◽  
Kidney Function ◽  
Blood Pressure Control ◽  
Pressure Control ◽  
Artery Stenosis ◽  
Post Transplant ◽  
Transplant Renal Artery Stenosis

scholarly journals Effect of Intensive Versus Standard Blood Pressure Control on Stroke Subtypes

Hypertension ◽  
2021 ◽  
Vol 77 (4) ◽  
pp. 1391-1398
Author(s):  
Clinton B. Wright ◽  
Alexander P. Auchus ◽  
Alan Lerner ◽  
Walter T. Ambrosius ◽  
Hakan Ay ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ischemic Stroke ◽  
Blood Pressure Control ◽  
Standard Treatment ◽  
Pressure Control ◽  
Intensive Treatment ◽  
Large Artery ◽  
Stroke Subtypes ◽  
Small Artery Occlusion ◽  
Blood Pressures

In the SPRINT (Systolic Blood Pressure Intervention Trial), the number of strokes did not differ significantly by treatment group. However, stroke subtypes have heterogeneous causes that could respond differently to intensive blood pressure control. SPRINT participants (N=9361) were randomized to target systolic blood pressures of <120 mm Hg (intensive treatment) compared with <140 mm Hg (standard treatment). We compared incident hemorrhage, cardiac embolism, large- and small-vessel infarctions across treatment arms. Participants randomized to the intensive arm had mean systolic blood pressures of 121.4 mm Hg in the intensive arm (N=4678) and 136.2 mm Hg in the standard arm (N=4683) at one year. Sixty-nine strokes occurred in the intensive arm and 78 in the standard arm when SPRINT was stopped. The breakdown of stroke subtypes across treatment arms included hemorrhagic (intensive treatment, n=6, standard treatment, n=7) and ischemic stroke subtypes (large artery atherosclerosis: intensive treatment n=11, standard treatment, n=13; cardiac embolism: intensive treatment n=11, standard treatment n=15; small artery occlusion: intensive treatment n=8, standard treatment n=8; other ischemic stroke: intensive treatment n=3, standard treatment n=1). Fewer strokes occurred among participants without prior cardiovascular disease in the intensive (n=43) than the standard arm (n=61), but the difference did not reach predefined statistical significance level of 0.05 ( P =0.09). The interaction between baseline cardiovascular risk factor status and treatment arm on stroke risk did not reach significance ( P =0.05). Similar numbers of stroke subtypes occurred in the intensive BP control and standard control arms of SPRINT.

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