scholarly journals Telomere length and cognitive function in southern Chinese community-dwelling male elders

2013 ◽  
Vol 42 (4) ◽  
pp. 450-455 ◽  
Author(s):  
S. L. Ma ◽  
E. S. S. Lau ◽  
E. W. C. Suen ◽  
L. C. W. Lam ◽  
P. C. Leung ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Telomere Length ◽  
Community Dwelling ◽  
Chinese Community ◽  
Southern Chinese

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

2017 ◽  
Vol 44 (3-4) ◽  
pp. 232-243 ◽  
Author(s):  
Jee-Yon Lee ◽  
Jung-Ha Kim ◽  
Duk-Chul Lee
Keyword(s):  
Mitochondrial Dna ◽  
Cognitive Function ◽  
Telomere Length ◽  
Odds Ratio ◽  
Copy Number ◽  
Adjusted Odds Ratio ◽  
Community Dwelling ◽  
Mtdna Copy Number ◽  
Old Adults ◽  
Combined Impact

Background: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. Methods: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. Results: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). Conclusion: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults.

The relationship between activity level and cognitive function in Chinese community-dwelling elderly

2021 ◽  
pp. 1-9
Author(s):  
Man-Li Liu ◽  
Li-Jun Jiang ◽  
Wen-Xiao Wang ◽  
Xiao Zhang ◽  
Xiao-Hua Xing ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Community Dwelling ◽  
Activity Level ◽  
Chinese Community ◽  
The Relationship

scholarly journals Biomarkers for Cognitive Aging Part I

2011 ◽  
Vol 14 (2) ◽  
pp. 124-132 ◽  
Author(s):  
Kathleen C. Insel ◽  
Carrie J. Merkle ◽  
Chao-Pin Hsiao ◽  
Amy N. Vidrine ◽  
David W. Montgomery
Keyword(s):  
Blood Pressure ◽  
Cognitive Function ◽  
Telomere Length ◽  
Cognitive Aging ◽  
Quantitative Polymerase Chain Reaction ◽  
Community Dwelling ◽  
Physiological Age ◽  
Chronological Age ◽  
Mononuclear Leukocytes ◽  
Cognitive Assessments

Chronological age is used as a marker for age-associated changes in cognitive function. However, there is great interindividual variability in cognitive ability among people of the same age. Physiological age rather than chronological age should be more closely associated with age-related cognitive changes because these changes are not universal and are likely dependent on several factors in addition to the number of years lived. Cognitive function is associated with successful self-management, and a biological marker that reflects physiological age and is associated with cognitive function could be used to identify risk for failure to self-manage. The purpose of this study was to investigate the association between telomere length, a known biomarker of age; blood pressure; cognitive assessments; and adherence to antihypertensive medication among community-dwelling middle-aged and older adults. The authors administered a battery of cognitive assessments to 42 participants ( M = 69 years of age), collected blood samples, and isolated peripheral blood mononuclear leukocytes for genomic DNA. The authors determined relative telomere length using Cawthon’s method for real-time quantitative polymerase chain reaction (RT-qPCR) and measured medication adherence using an electronic medication monitoring system (MEMS by Aardex) over 8 weeks. Findings indicate that telomere length was inversely associated with systolic blood pressure ( r = −.38, p < .01) and diastolic blood pressure ( r = −.42, p < .01) but not with cognitive assessments or adherence. The authors discuss the nonsignificant findings between telomere length and cognitive assessments including the potential modifying role of gender.

scholarly journals P4-130: Telomere length and cognitive function in community-dwelling elders: Findings from the Health Aging and Body Composition (Health ABC) Study

2008 ◽  
Vol 4 ◽  
pp. T708-T708
Author(s):  
Kristine Yaffe ◽  
Karla Lindquist ◽  
Molly Kluse ◽  
Richard Cawthon ◽  
Tamara Harris ◽  
...  
Keyword(s):  
Body Composition ◽  
Cognitive Function ◽  
Telomere Length ◽  
Community Dwelling ◽  
Health Aging
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