scholarly journals Effects of ageing on gastrointestinal motor function

2004 ◽  
Vol 33 (2) ◽  
pp. 154-159 ◽  
Author(s):  
J. L. Madsen
Author(s):  
M Horowitz ◽  
RJL Fraser ◽  
GS Hebbard ◽  
KL Jones ◽  
JM Wishart ◽  
...  

2016 ◽  
Vol 26 (11) ◽  
pp. 1253-1258
Author(s):  
Min Woo Kim ◽  
Hyun Jin Kim ◽  
Moon-Moo Kim ◽  
Eun-Woo Lee ◽  
Hyun Ju Kwon ◽  
...  

2001 ◽  
Vol 21 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Esther Rusthoven ◽  
Monique Trijbels–Smeulders ◽  
Floor A.P.T. Engels ◽  
Jaap Groothoff ◽  
Jules J.M. Tolboom ◽  
...  

Gut ◽  
1995 ◽  
Vol 36 (5) ◽  
pp. 743-748 ◽  
Author(s):  
M R von der Ohe ◽  
M Camilleri ◽  
G M Thomforde ◽  
G G Klee

1992 ◽  
Vol 103 (4) ◽  
pp. 1386
Author(s):  
J.E.T. Fox-Threlkeld ◽  
C. Haugh ◽  
H.-D. Allescher ◽  
G. Tougas ◽  
P. Vergara ◽  
...  

2007 ◽  
Vol 292 (4) ◽  
pp. G1099-G1104 ◽  
Author(s):  
Reawika Chaikomin ◽  
Keng Liang Wu ◽  
Selena Doran ◽  
Karen L. Jones ◽  
Andre J. P. M. Smout ◽  
...  

Upper gastrointestinal motor function and incretin hormone secretion are major determinants of postprandial glycemia and insulinemia. However, the impact of small intestinal flow events on glucose absorption and incretin release is poorly defined. Intraluminal impedance monitoring is a novel technique that allows flow events to be quantified. Eight healthy volunteers were studied twice, in random order. A catheter incorporating six pairs of electrodes at 3-cm intervals, and six corresponding manometry sideholes, was positioned in the duodenum. Hyoscine butylbromide (20 mg) or saline was given as an intravenous bolus, followed by a continuous intravenous infusion of either hyoscine (20 mg/h) or saline over 60 min. Concurrently, glucose and 3- O-methylglucose (3-OMG) were infused into the proximal duodenum (3 kcal/min), with frequent blood sampling to measure glucose, 3-OMG, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The frequency of duodenal pressure waves and propagated pressure wave sequences was reduced by hyoscine in the first 10 min ( P < 0.01 for both), but not after that time. In contrast, there were markedly fewer duodenal flow events throughout 60 min with hyoscine ( P < 0.005). Overall, blood glucose ( P < 0.01) and plasma 3-OMG concentrations ( P < 0.05) were lower during hyoscine than saline, whereas plasma insulin, GLP-1, and GIP concentrations were initially ( t = 20 min) lower during hyoscine ( P < 0.05). In conclusion, intraluminal impedance measurement may be more sensitive than manometry in demonstrating alterations in duodenal motor function. A reduction in the frequency of duodenal flow events is associated with a decreased rate of glucose absorption and incretin release in healthy subjects.


1984 ◽  
pp. 583-591 ◽  
Author(s):  
H. S. Ormsbee ◽  
F. C. Barone ◽  
D. M. Lombardi ◽  
L. C. McCartney

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