scholarly journals 98 Rationality of Hypnosedative Use in Seniors in Acute Care: Outputs of the Inomed and Euroageism Projects

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
O Antonenko ◽  
A Zelinková ◽  
M Halačová ◽  
S Grešáková ◽  
J Brkic ◽  
...  
Keyword(s):  
Czech Republic ◽  
Beta Blockers ◽  
Potentially Inappropriate Medications ◽  
The Czech Republic ◽  
Hospitalized Older Adults ◽  
Sedative Drugs ◽  
Explicit Criteria ◽  
Inappropriate Medications ◽  
N Use

Abstract Introduction Insomnia is a frequent problem in acutely hospitalized older adults, particularly in those suffering from polymorbidity and treated by polypharmacy. The aim of our study was to describe the prevalence of insomna and patterns of inappropriately prescribed hypnosedatives in acutely hospitalized older patients in the Czech Republic. Methods 438 patients (≥65 yrs) acutely hospitalized at 3 geriatric clinics (Brno, Hradec Králové, Praha) in the Czech Republic underwent a comprehensive geriatric assessment (CGA) using the EUROAGEISM H2020 assessment protocols. Descriptive statistics was used to determine the prevalence of insomnia and use of hypnosedatives. Explicit criteria of potentially inappropriate medications (PIMs), mainly 2019 Beers criteria and 2015 EU(7)-PIM list were applied to determine inappropriate patterns of hypnosedatives use. Results 16.9% (N = 74) seniors had diagnosed insomnia in their medical records, but 34,6% used hypnosedatives in the evening or at night (e/n). 13.8% reported e/n use of drugs aggravating insomnias (particularly beta-blockers- 6.4%, diuretics-2.5% and theophylline- 2.1%). Most frequent hypnosedatives used were: antipsychotics e/n (18.5%), Z-drugs (16,2%) and benzodiazepines e/n (BZD, 14,2%). Non-geriatric doses were determined in users of Z-drugs (10.5%) and sedative antidepressants e/n (1,8%), longer than recommended geriatric duration of therapy has been described for Z-drugs (5.9%,>1 month), BZDs e/n (5,3%,>1 month) and sedative antidepressants e/n (3,3%, >6 months). In total, 1PIM was prescribed to 7.5% of seniors (N = 33), 2PIMs to 2.5% and 3PIMs to 1,1% of seniors. Combination of hypnotics and other sedative drugs was documented in 5.9% of cases. Conclusion Inappropriate patterns of hypnosedative use in acutely hospitalized seniors in the Czech Republic at geriatric clinics were found particularly in excessive indication of antipsychotics e/n, inappropriate dosing of Z-drugs and long-term use of BZDs e/n. Supported by: InoMed project (reg. No: CZ.02.1.01/0.0/0.0/18_069/0010046, 2019–2022), EUROAGEISM H2020-MCSF-ITN-764632 project, PROGRESS Q42 Faculty of Pharmacy, Charles University, SVV 260417.

97 Prescribing of Hypnosedatives in Seniors in Ambulatory Care in the Czech Republic: Inomed and Euroageism Project Findings

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
O Antonenko ◽  
K Puldová ◽  
M Halačová ◽  
S Grešáková ◽  
J Brkic ◽  
...  
Keyword(s):  
Czech Republic ◽  
Drug Use ◽  
Treatment Strategies ◽  
Potentially Inappropriate Medications ◽  
The Czech Republic ◽  
Nonpharmacological Treatment ◽  
Study Protocols ◽  
High Prevalence ◽  
Inappropriate Medications

Abstract Introduction Among psychotropic drugs, particularly hypnotics are often used by ambulatory seniors due to high prevalence of insomnia in higher age. This study focused on describing the prevalence of insomnia, prevalence of hypnosedative drug use and inappropriate patterns of their prescribing (nongeriatric doses, nongeriatric lenght of therapy) in ambulatory seniors in the Czech Republic. Methods There were 563 ambulatory geriatric patients (≥65 years) included in the study, from 4 geriatric ambulances (regionally different sites) in the Czech Republic. All patients have been assessed using comprehensive geriatric assessment (CGA) using the EUROAGEISM H2020 study protocols. Prevalences of insomnia, hypnosedative drug use and use of drugs that may exacerbate insomnias were documented by descriptive statistics, as well as the prevalence of potentially inappropriate medications in older patients (PIMs, selectively for hypnosedatives, defined by 2019 Beers criteria and 2015 EU(7)-PIM list). Results 30.6% (N = 172) of ambulatory seniors suffered from insomnias and the majority of patients were treated pharmacologically (24.0%), nonpharmacologic procedures were used rarely (0.5%). Hypnosedatives in the evening or at night (e/n) were mostly prescribed in the age group of patients 84–94 years (42.8%) and most often these were Z-drugs (8.2%), benzodiazepines (BZDs, 7.6%) and from „off-label “hypnotics antipsychotics (17.8%,!17% of users 6 months) and sedative antidepressants (9.2%). In nongeriatric doses and nongeriatric duration of therapy (>4 weeks) there were most often prescribed Z-drugs (6.0% and 2,7%, respectively) and BZDs (2,7% and 11%). Conclusion In ambulatory Czech seniors we documented that one third suffered from insomnias and minimally were applied nonpharmacological treatment strategies. From nongeriatric procedures in hypnosetive drug use were most often described long-term use of antipsychotics e/n, non-geriatric dosing of Z-drugs and long-term use of BZDs e/n. Supported by: InoMed project (reg. No: CZ.02.1.01/0.0/0.0/18_069/0010046, 2019–2022), EUROAGEISM H2020-MCSF-ITN-764632 project, PROGRESS Q42 Faculty of Pharmacy, Charles University, SVV 260417.

Long-term changes in body weight, BMI, and adiposity rebound among children and adolescents in the Czech republic

2007 ◽  
Vol 5 (3) ◽  
pp. 409-425 ◽  
Author(s):  
J. Vignerová ◽  
L. Humeníkova ◽  
M. Brabec ◽  
J. Riedlová ◽  
P. Bláha
Keyword(s):  
Body Weight ◽  
Czech Republic ◽  
Children And Adolescents ◽  
The Czech Republic ◽  
Adiposity Rebound ◽  
Long Term Changes

scholarly journals Loose Monetary Policy and Corporate Investment of Manufacturing Firms in the Czech Republic

2018 ◽  
Vol 18 (4) ◽  
pp. 371-385
Author(s):  
Veronika Kajurová ◽  
Dagmar Linnertová
Keyword(s):  
Monetary Policy ◽  
Czech Republic ◽  
Interest Rates ◽  
Corporate Investment ◽  
Manufacturing Firms ◽  
Investment Activity ◽  
The Czech Republic ◽  
Low Interest Rates ◽  
Negative Effect

Abstract The aim of the paper is to evaluate the effects of loose monetary policy on corporate investment of manufacturing firms in the Czech Republic during the period between 2006 and 2015. The main focus of the paper is on the effect of low interest rates on investment activity of Czech firms; additionally, the effects of interactions between interest rate and other firm-specific variables are investigated. The results indicate that corporate investment is positively associated with firm size, investment opportunities, and long term debt. Also, a negative effect of the cash position is found. Further, the findings show that monetary policy is a significant determinant of firm investment activity: when the monetary policy is loose, investment is positively affected. Furthermore, differences in the determinants of investment between highly and low leveraged firms were revealed.

scholarly journals Values of rainfall erosivity factor for the Czech Republic

2013 ◽  
Vol 61 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Miloslav Janeček ◽  
Vít Květoň ◽  
Eliška Kubátová ◽  
Dominika Kobzová ◽  
Michaela Vošmerová ◽  
...  
Keyword(s):  
Czech Republic ◽  
Water Erosion ◽  
Rainfall Erosivity ◽  
The Czech Republic ◽  
Average Value ◽  
R Factor ◽  
The Usa ◽  
Time Division ◽  
R Factors

Abstract The processing of ombrographic data from 29 meteorological stations of the Czech Hydrometeorological Institute (CHMI), according to the terms of the Universal Soil Loss Equation for calculating long term loss of soil through water erosion, erosion hazard rains and their occurrence have been selected, with their relative amount and erosiveness - R-Factors determined for each month and years. By comparing the value of the time division of the R-Factor in the area of the Czech Republic and in selected areas of the USA it has been demonstrated that this division may be applied in the conditions of the Czech Republic. For the Czech Republic it is recommended to use the average value R = 40 based on the original evaluation.

scholarly journals STOPP/START Criteria and Their Role as a Clinical Tool in Routine Practice

2015 ◽  
Vol 2 (6) ◽  
Author(s):  
Denis O'Mahony
Keyword(s):  
Older Persons ◽  
Screening Tool ◽  
Routine Practice ◽  
Potentially Inappropriate Medications ◽  
Clinical Tool ◽  
Treatment Start ◽  
Start Criteria ◽  
Alternative Set ◽  
Explicit Criteria ◽  
Inappropriate Medications

Screening Tool of Older Persons’ Prescriptions (STOPP)/Screening Tool to Alert to Right Treatment (START) criteria was first published in 2008, primarily as an alternative set of explicit criteria for potentially inappropriate medications (PIMs) to Beers criteria.

scholarly journals Consequences of the Public Contract Law for Purchase of Scientific Appliances in the Czech Republic

2015 ◽  
Vol 63 (2) ◽  
pp. 675-681
Author(s):  
Martin Vyklický
Keyword(s):  
Czech Republic ◽  
Contract Law ◽  
Public Funds ◽  
The Czech Republic ◽  
The Public ◽  
Flow Of Funds ◽  
Science And Research ◽  
Research Equipment ◽  
Public Contract

This article essentially covers in more detail the consequences of the present wording of the Public Contract Law for purchase of scientific appliances in the Czech Republic. The beginning of the article deals with increasing public expenses in research; then, the problem is defined concerning unsuitable wording of certain provisions of the Public Contract Law; while subsequently, the solution for the problem is searched together with the final comments. Investing of public funds into science and research is probably the most efficient in a long-term horizon. However, the flow of funds for acquisition of scientific and research equipment should be supported by appropriate legislation with such wording and form not to prevent purchases of that equipment. Availability of public funds for something which in fact cannot be, due to wrongly set legislation, acquired by a contracting authority is the problem which must be eliminated through timely implementation of the above proposed changes in the Public Contract Law.

scholarly journals Comparison of hospitalized and ambulatory patients with heart failure in the Czech Republic and Europe. Data from the ESC Heart Failure Long-Term Registry

Cor et Vasa ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. e6-e11 ◽  
Author(s):  
Jan Krupička ◽  
Anna Andrusková ◽  
Markéta Hegarová ◽  
Marie Lazarová ◽  
Filip Málek ◽  
...  
Keyword(s):  
Heart Failure ◽  
Czech Republic ◽  
The Czech Republic ◽  
Patients With Heart Failure ◽  
Ambulatory Patients

P448: Potentially inappropriate medications detected by explicit criteria; are they really inappropriate?

2014 ◽  
Vol 5 ◽  
pp. S222-S223
Author(s):  
I. Lozano-Montoya ◽  
M. Vélez-Díaz-Pallarés ◽  
E. Delgado-Silveira ◽  
B. Montero Errasquín ◽  
A.J. Cruz-Jentoft
Keyword(s):  
Potentially Inappropriate Medications ◽  
Explicit Criteria ◽  
Inappropriate Medications
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