scholarly journals Motoric cognitive risk syndrome and incident dementia in older adults from the Québec NuAge cohort

2020 ◽  
Author(s):  
Olivier Beauchet ◽  
Harmehr Sekhon ◽  
Liam Cooper-Brown ◽  
Cyrille P Launay ◽  
Pierrette Gaudreau ◽  
...  
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Walking Speed ◽  
Community Dwelling ◽  
Slow Walking ◽  
Cognitive Risk ◽  
Incident Dementia ◽  
Cognitive Complaint ◽  
Slow Walking Speed

Abstract Background The co-occurrence of slow walking speed and subjective cognitive complaint (SCC) in non-demented individuals defines motoric cognitive risk syndrome (MCR), which is a pre-dementia stage. There is no information on the association between MCR and incident dementia in Québec’s older population. Objective The study aims to examine the association of MCR and its individual components (i.e. SCC and slow walking speed) with incident dementia in community-dwelling older adults living in the province of Québec (Canada). Design Québec older people population-based observational cohort study with 3 years of follow-up. Setting Community dwellings. Subjects A subset of participants (n = 1,098) in ‘Nutrition as a determinant of successful aging: The Québec longitudinal study’ (NuAge). Methods At baseline, participants with MCR were identified. Incident dementia was measured at annual follow-up visits using the Modified Mini-Mental State (≤79/100) test and Instrumental Activity Daily Living scale (≤6/8) score values. Results The prevalence of MCR was 4.2% at baseline and the overall incidence of dementia was 3.6%. MCR (Hazard Ratio (HR) = 5.18, with 95% confidence interval (CI) = [2.43–11.03] and P ≤ 0.001) and SCC alone (HR = 2.54, with 95% CI = [1.33–4.85] and P = 0.005) were associated with incident dementia, but slow walking speed was not (HR = 0.81, with 95%CI = [0.25–2.63] and P = 0.736). Conclusions MCR and SCC are associated with incident dementia in NuAge study participants.

Pre-Dementia Stages and Incident Dementia in the NuAge Study

2021 ◽  
Vol 80 (4) ◽  
pp. 1465-1470
Author(s):  
Olivier Beauchet ◽  
Harmehr Sekhon ◽  
Cyrille P. Launay ◽  
Pierrette Gaudreau ◽  
José A. Morais ◽  
...  
Keyword(s):  
Older Adults ◽  
Successful Aging ◽  
Population Based ◽  
Community Dwelling ◽  
Cognitive Risk ◽  
Incident Dementia ◽  
Annual Visit ◽  
Observational Cohort ◽  
Community Dwelling Older Adults

Background: Motoric cognitive risk syndrome (MCR) and mild cognitive impairment (MCI) are two pre-dementia stages with an overlap, which may influence the risk for dementia. Objective: The study aims to examine the association of MCR, MCI, and their combination with incident dementia in Quebec community-dwelling older adults. Methods: 1,063 older adults (i.e., ≥65) were selected from a population-based observational cohort study known as the “Nutrition as a determinant of successful aging: The Quebec longitudinal study” (NuAge). Participants were separated into four groups at the baseline assessment: those without MCR and MCI (i.e., cognitively healthy individual; CHI), those with MCR alone, those with MCI alone, and those with MCR plus MCI. Incident dementia was recorded at each annual visit during a 3-year follow-up. Results: The prevalence of CHI was 87.2%, MCR 3.0%, MCI 8.8%, and MCR plus MCI 0.9%. The overall incidence of dementia was 2.4% and was significantly associated with MCR alone (Odd Ratio (OR) = 5.00 with 95% Confidence interval (CI) = [1.01;24.59] and p = 0.049), MCI alone (OR = 6.04 with 95% CI = [2.36;15.47] and p≤0.001), and the combination of MCR and MCI (OR = 25.75 with 95% CI = [5.32;124.66] and p≤0.001). Conclusion: Combining MCR and MCI increased the risk for incident dementia. These results also demonstrated that this combination is a better predictor of dementia than MCI or MCR alone.

scholarly journals Associations between locomotive and non-locomotive physical activity and physical performance in older community-dwelling females with and without locomotive syndrome: a cross-sectional study

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Tomohiro Nishimura ◽  
Atsushi Hagio ◽  
Kanako Hamaguchi ◽  
Toshiyuki Kurihara ◽  
Motoyuki Iemitsu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Walking Speed ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Step Test ◽  
Locomotive Syndrome ◽  
Sectional Study ◽  
Cross Sectional ◽  
Slow Walking ◽  
Slow Walking Speed

Abstract Background Locomotive syndrome (LS) is a condition of reduced mobility due to a disorder of the locomotive system. Increasing moderate to vigorous physical activity (MVPA) has been recommended to prevent LS. However, to increase daily MVPA is difficult for older people with LS. The MVPA consists of not only locomotive activities such as walking but also non-locomotive activities such as household activities. The aim of this study was to examine the associations between locomotive/non-locomotive MVPA and physical performance in older females with and without LS. Methods Participants of this cross-sectional study were 143 older community-dwelling Japanese females. The participants were divided into two groups based on the results of the stand-up test: the normal group (NL) (n = 86) and the LS group (n = 57). Both the locomotive and non-locomotive PA seperately measured with its intensity. The intensity of physical activity (PA) was calculated as METs and classified as sedentary behavior (SB 1–1.5 metabolic equivalent tasks (METs)), low-intensity physical activity (LPA 1.6–2.9 METs), and MVPA (≥ 3 METs). For example, locomotive LPA is slow walking speed of 54 m/min, and locomotive MVPA is walking speed of 67 m/min. While non-locomotive LPA is office work and cooking, non-locomotive MVPA is housecleaning. Physical function was evaluated by handgrip strength, walking speed, and 2-step test. Results Walking speed, hand-grip strength, 2-step test, daily step counts, and all PA measurements were not significantly different between two groups. In the LS, locomotive MVPA (r = 0.293, p < 0.05) and total MVPA (r = 0.299, p < 0.05) was significantly correlated with walking speed, but not in the NL. Conclusions Walking speed was positively correlated with locomotive MVPA and total MVPA in the LS group, but not in NL group. This result suggests that slow walking speed in older people with LS occur in connection with lower locomotive MVPA and total MVPA.

scholarly journals Using hand grip strength to detect slow walking speed in older adults: the Yilan study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yen-Huai Lin ◽  
Hsi-Chung Chen ◽  
Nai-Wei Hsu ◽  
Pesus Chou
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Walking Speed ◽  
Area Under The Curve ◽  
Hand Grip Strength ◽  
Stepwise Multiple Linear Regression ◽  
Optimal Cutoff ◽  
Hand Grip ◽  
Slow Walking ◽  
Slow Walking Speed

Abstract Background Walking speed is an important health indicator in older adults, although its measurement can be challenging because of the functional decline due to aging and limited environment. The aim of this study was to examine whether hand grip strength can be a useful proxy for detecting slow walking speed in this population. Methods A cross-sectional study was conducted using the cohort from the Yilan Study in Taiwan. Community-dwelling older adults aged 65 years and older were included. Slow walking speed was defined as a 6-meter walking speed < 1.0 m/s, according to the 2019 Asian Working Group for Sarcopenia diagnostic criteria. Stepwise multiple linear regression was used to determine the most significant variables associated with walking speed. Receiver operating characteristic analysis was used to determine the optimal cutoff values for hand grip strength in detecting slow walking speed. Results A total of 301 participants with an average age of 73.9 ± 6.8 years were included; 55.1 % participants were women. In stepwise multiple linear regression analysis that included various variables, hand grip strength was found to be the most explainable factor associated with walking speed among all participants and among participants of each sex. The optimal cutoff values for hand grip strength in the detection of slow walking speed were 19.73 kg for all participants (sensitivity: 55 %, specificity: 83 %, area under the curve: 0.74, accuracy: 66.9 %), 35.10 kg for men (sensitivity: 92 %, specificity: 42 %, area under the curve: 0.70, accuracy: 66.4 %), and 17.93 kg for women (sensitivity: 62 %, specificity: 80 %, area under the curve: 0.76, accuracy: 67.9 %). Conclusions Hand grip strength was found to be a useful proxy for the identification of slow walking speed in older adults.

scholarly journals Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study

BMJ ◽  
2009 ◽  
Vol 339 (nov10 2) ◽  
pp. b4460-b4460 ◽  
Author(s):  
J. Dumurgier ◽  
A. Elbaz ◽  
P. Ducimetiere ◽  
B. Tavernier ◽  
A. Alperovitch ◽  
...  
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Walking Speed ◽  
Cardiovascular Death ◽  
Slow Walking ◽  
Slow Walking Speed

scholarly journals The association between metabolic syndrome and successful aging- using an extended definition of successful aging

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0260550
Author(s):  
Yi-Hsuan Lin ◽  
Jeng-Min Chiou ◽  
Ta-Fu Chen ◽  
Liang-Chuan Lai ◽  
Jen-Hau Chen ◽  
...  
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Successful Aging ◽  
Density Lipoprotein ◽  
Community Dwelling ◽  
University Hospital ◽  
Time Interaction ◽  
Definition Of ◽  
Community Dwelling Older Adults

Objectives To examine the association between metabolic syndrome (MetS) and successful aging among community-dwelling older adults. Methods Adults aged ≥ 65 years who participated in the senior health checkup program at National Taiwan University Hospital during 2011–2013 were recruited (N = 467 at baseline). The participants were followed after 4 years and 6 years. MetS was assessed at baseline. Successful aging was evaluated at baseline, 4-year follow-up, and 6-year follow-up. We adopted an extended definition of successful aging, which was defined as three major domains: physiological, psychological, and sociological and economic domains. Generalized linear mixed models were used to assess the association between MetS and successful aging adjusting for time (follow-up years), age, sex, years of education, alcohol consumption and MetS×time interaction term. Results The mean age of the study population was 72.9 (SD 5.5) years. The absence of baseline MetS had a positive effect on the probability of successful aging over six years. The absences of abdominal obesity, hyperglycemia, reduced high-density lipoprotein cholesterol, and hypertension were associated with the physiological successful aging. The absence of hypertension was the most significant predictor of physiological successful aging [aOR (95% CI) = 2.76 (1.67–4.58), p<0.001]. Significant increased trend was found in the overall and physiological successful aging across MetS status (No MetS, pre MetS, MetS; Ptrend <0.001). Conclusions We found that MetS is a risk factor of successful aging among community-dwelling older adults. Public health policy should aim at avoidance of MetS in order to facilitate successful aging in older population.

scholarly journals What cut-point in gait speed best discriminates community dwelling older adults with mobility complaints from those without? A pooled analysis from the Sarcopenia Definitions and Outcomes Consortium

2021 ◽  
Author(s):  
Peggy M Cawthon ◽  
Sheena M Patel ◽  
Stephen B Kritchevsky ◽  
Anne B Newman ◽  
Adam Santanasto ◽  
...  
Keyword(s):  
Walking Speed ◽  
Regression Tree ◽  
Pooled Analysis ◽  
Community Dwelling ◽  
Mobility Limitation ◽  
Classification And Regression Tree ◽  
Cut Points ◽  
Cart Analysis ◽  
Slow Walking ◽  
Slow Walking Speed

Abstract Background Cut-points to define slow walking speed have largely been derived from expert opinion. Methods Study participants (13,589 men and 5,043 women aged ≥65years) had walking speed (m/s) measured over 4-6 meters (mean ± SD: 1.20 ± 0.27 m/s in men and 0.94 ± 0.24 m/s in women.) Mobility limitation was defined as self-reported any difficulty with walking ~1/4 mile (prevalence: 12.6% men, 26.4% women). Sex-stratified classification and regression tree (CART) models with 10-fold cross-validation identified walking speed cut-points that optimally discriminated those who reported mobility limitation from those who did not. Results Among 5,043 women, CART analysis identified two cut-points, classifying 4,144 (82.2%) with walking speed ≥0.75 m/s, which we labeled as “fast”; 478 (9.5%) as “intermediate” (walking speed ≥0.62 m/s but &lt;0.75 m/s); and 421 (8.3%) as “slow” (walking speed &lt;0.62 m/s). Among 13,589 men, CART analysis identified three cut-points, classifying 10,001 (73.6%) with walking speed ≥1.00 m/s (“very fast”); 2,901 (21.3%) as “fast” (walking speed ≥0.74 m/s but &lt;1.00 m/s); 497 (3.7%) as “intermediate” (walking speed ≥0.57 m/s but &lt;0.74 m/s); and 190 (1.4%) as “slow” (walking speed &lt;0.57 m/s). Prevalence of self-reported mobility limitation was lowest in the “fast” or “very fast” (11% for men and 19% for women) and highest in the “slow” (60.5% in men and 71.0% in women). Rounding the two slower cut-points to 0.60 m/s and 0.75 m/s reclassified very few participants. Conclusions Cut-points in walking speed of ~0.60 m/s and 0.75 m/s discriminate those with self-reported mobility limitation from those without.

scholarly journals Late-Life Depressive Symptomatology, Motoric Cognitive Risk Syndrome, and Incident Dementia: The “NuAge” Study Results

2021 ◽  
Vol 13 ◽  
Author(s):  
Olivier Beauchet ◽  
Harmehr Sekhon ◽  
Cyrille P. Launay ◽  
Pierrette Gaudreau ◽  
José A. Morais ◽  
...  
Keyword(s):  
Depressive Symptomatology ◽  
Depression Scale ◽  
Late Life ◽  
Community Dwelling ◽  
Cognitive Risk ◽  
Incident Dementia ◽  
Cognitive Complaint ◽  
Increased Risk ◽  
Study Results ◽  
Community Dwellers

Background: Late-life depressive symptomatology and motoric cognitive risk syndrome (MCR) have independently been associated with an increased risk for incident dementia. This study aimed to examine the association of late-life depressive symptomatology, MCR, and their combination on incident dementia in community-dwelling older adults living in Quebec (Canada).Methods: The study was carried out in a subset of 1,098 community dwellers aged ≥65 years recruited in the “Nutrition as a determinant of successful aging: The Quebec longitudinal study” (NuAge), an observational prospective cohort study with 3 years follow-up. At baseline, MCR was defined by the association of subjective cognitive complaint with slow walking speed, and late-life depressive symptomatology with a 30-item Geriatric Depression Scale (GDS) score &gt;5/30. Incident dementia, defined as a Modified Mini-Mental State score ≤79/100 test and Instrumental Activity Daily Living score &lt;4/4, was assessed at each annual visit.Results: The prevalence of late-life depressive symptomatology only was 31.1%, of MCR only 1.8%, and the combination of late-life depressive symptomatology and MCR 2.4%. The combination of late-life depressive symptomatology and MCR at baseline was associated with significant overall incident dementia (odds ratio (OR) = 2.31 with P ≤ 0.001) but not for MCR only (OR = 3.75 with P = 0.186) or late-life depressive symptomatology only (OR = 1.29 with P = 0.276).Conclusions: The combination of late-life depressive symptomatology and MCR is associated with incident dementia in older community dwellers. The results suggested an interplay between late-life depressive symptomatology and MCR exposing them to an increased risk for dementia.

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