scholarly journals Telomere length and its relationships with lifestyle and behavioural factors: variations by sex and race/ethnicity

2020 ◽  
Author(s):  
Chirag M Vyas ◽  
Soshiro Ogata ◽  
Charles F Reynolds ◽  
David Mischoulon ◽  
Grace Chang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Telomere Length ◽  
Quantitative Polymerase Chain Reaction ◽  
Healthy Ageing ◽  
Daily Consumption ◽  
Heavy Smoking ◽  
Potential Biomarker ◽  
Race Ethnicity ◽  
Behavioural Factors

Abstract Background Adherence to healthy lifestyles/behaviours promotes healthy ageing. However, little is known about whether age, sex and/or race/ethnicity moderate associations of lifestyle/behavioural factors with relative telomere length (RTL), a potential biomarker of ageing. Methods We included 749 midlife to older non-Hispanic White (n = 254), Black (n = 248) and Hispanic (n = 247) US participants [mean (standard deviation) age = 69.3 (7.2) years; women: 50.5%]. We extracted genomic DNA from peripheral leucocytes. RTL was assayed using real-time quantitative polymerase chain reaction. Multivariable regression was used to examine associations between lifestyle/behavioural exposures (i.e. physical activity, alcohol consumption, smoking and depression) with RTL. Results Increasing chronological age was associated with shorter RTL (P < 0.01). Higher physical activity was associated with longer RTL (P-trend = 0.03); daily versus never/rare alcohol consumption and 30+ versus <5 smoking pack-year were associated with shorter RTLs (P-trend = 0.02). Associations varied significantly by sex and race/ethnicity. The association between physical activity and longer RTL appeared strongest among non-Hispanic Whites (P-interaction = 0.01). Compared to men, women had stronger associations between heavy smoking and shorter RTLs (P-interaction = 0.03). Light/moderate alcohol consumption (monthly/weekly) was associated with longer RTL among non-Hispanic Whites, while daily consumption was related to shorter RTLs among Blacks and Hispanics (P-interactions < 0.01). Associations of daily alcohol and heavy smoking with shorter RTLs were particularly apparent among Black women. Conclusion We observed novel variations by sex and race/ethnicity in associations between lifestyle/behavioural factors and RTL. Further work is needed to replicate these findings and to address potential public health implications for modifying strategies by sex or across racial/ethnic groups to optimise lifestyles/behaviours for healthy ageing.

scholarly journals The Contribution of Health Behaviors to Depression Risk across Birth Cohorts

2021 ◽  
Author(s):  
Maria Gueltzow ◽  
Maarten J Bijlsma ◽  
Frank J van Lenthe ◽  
Mikko Myrskyla
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Birth Cohort ◽  
Decomposition Analysis ◽  
Minor Role ◽  
Drinking Patterns ◽  
Birth Cohorts ◽  
Depression Risk ◽  
Race Ethnicity ◽  
A Minor

Background: More recent birth cohorts are at a higher depression risk than cohorts born in the early twentieth century. We aimed to investigate to what extent changes in alcohol consumption, smoking, physical activity and obesity, contribute to these birth cohort variations. Methods: We analyzed panel data from US adults born 1916-1966 enrolled in the Health and Retirement Study (N=163,760 person-years). We performed a counterfactual decomposition analysis by combining age-period-cohort models with g-computation. This allowed us to compare the predicted probability of elevated depressive symptoms (CES-D 8 score ≥3) in the natural course to a counterfactual scenario where all birth cohorts had the health behavior of the 1945 birth cohort. We stratified analyses by sex and race/ethnicity. Results: Depression risk of the 1916-1949 and 1950-1966 birth cohort would be on average 2% (-2.3 to -1.7) and 0.5% (-0.9 to -0.1) higher had they had the alcohol consumption levels of the 1945 cohort. In the counterfactual with the 1945 BMI distribution, depression risk is on average 2.1% (1.8 to 2.4) higher for the 1916-1940 cohorts and 1.8% (-2.2 to -1.5) lower for the 1950-1966 cohorts. We find no cohort variations in depression risk for smoking and physical activity. The contribution of alcohol is more pronounced for Whites than for other race/ethnicity groups, and the contribution of BMI more pronounced for women than for men. Conclusion: Increased obesity levels exacerbated depression risk in recent birth cohorts in the US, while drinking patterns only played a minor role.

scholarly journals Combined Effect of Telomere Length and Mitochondrial DNA Copy Number As a Potential Biomarker Indicating PE Risk: a Case-Control Study in a Chinese Population

2022 ◽  
Author(s):  
Ruyi Zhang ◽  
Jiangbo Du ◽  
Zhendong Xiao ◽  
Yuan Jiang ◽  
Qiao Weng ◽  
...  
Keyword(s):  
Cord Blood ◽  
Telomere Length ◽  
Copy Number ◽  
Case Control Study ◽  
Quantitative Polymerase Chain Reaction ◽  
Maternal Blood ◽  
Case Control ◽  
Combined Effect ◽  
Potential Biomarker ◽  
Control Study

Abstract Purpose To explore changes of Telomere length (TL) and mitochondrial copy number (mtDNA-CN) in preeclampsia (PE) and to evaluatethe combined effect of maternal TL and mtDNA-CN on PE risk.Methods A case-control study of 471 subjects (130 PE cases and 341 age frequency matched controls) was conducted in Nanjing Drum Tower Hospital, Jiangsu Province of China. Relative telomere length (RTL) and mtDNA-CN were measured using quantitative polymerase chain reaction (qPCR) and PE risk was calculated between groups by logistic regression analyses.Results PE patients displayed longer RTL (0.48 versus 0.30) and higher mtDNA-CN (3.02 versus 2.00) in maternal bloodas well as longer cord blood RTL(0.61 versus 0.35) but lower mtDNA-CN (1.69 versus 5.49) in cord blood (all p<0.001). Exercise during pregnancy exerted an obvious effect of prolonging maternal telomere length. Multiparous, women with folic acid intake during early pregnancy and those delivered vaginally showed longer telomere length while those factors imposed no or opposite effect on RTL in PE cases. Furthermore, RTL and mtDNA-CN were positively correlated in controls (in maternal blood r=0.18, p<0.01; in cord blood r=0.19, p<0.001), but this correlation was disrupted in PE cases, no matter in maternal blood or in cord blood. Longer maternal RTL and higher mtDNA-CN were associated with higher risk of PE, and the ROC curve of RTL and mtDNA-CN in predicting PE risk presented an AUC of 0.755(95%CI: 0.698-0.812).Conclusions Interaction of TL and mtDNA-CN may play an important role in pathogenesis of PE and it could be a potential biomarker indicating PE risk.

scholarly journals HEALTH TRAJECTORIES OVER TIME IN THE ATHLOS PROJECT: FINDINGS FROM MULTIPLE COHORTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S798-S798
Author(s):  
Matthew Prina
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Cohort Studies ◽  
Healthy Ageing ◽  
The Third ◽  
Health Trajectories ◽  
Working Together ◽  
The Impact ◽  
Over Time

Abstract The ATHLOS (Ageing Trajectories of Health: Longitudinal Opportunities and Synergies) project is a consortium of 15 partners across Europe who are working together to understand patterns of healthy ageing trajectories, and to seek the factors that determine those patterns, in a harmonised dataset of 17 international cohort studies of ageing. During this symposium we will be presenting some of the work that has recently been carried out within this project. The symposium will consist of four talks: the first talk will introduce the project, and describe the preliminary work that took place within the first few years of the project, and the challenges faced by the consortium. The second talk will focus on the harmonisation process and on the development of the health metric, an indicator used to measure healthy ageing in this project. The third talk will focus on inequalities in healthy ageing, specifically investigating the impact of education and wealth across cohorts. Finally, in the last talk we will describe the role of lifestyle behaviours (specifically physical activity, smoking and alcohol consumption) and their impact on healthy ageing trajectories.

scholarly journals The relationships of lifetime physical activity and diet with salivary cell telomere length in current ultra-endurance exercisers

2021 ◽  
pp. 1-11
Author(s):  
Karen Birkenhead ◽  
Anna Kuballa ◽  
Geoff P. Lovell ◽  
Susan I. Barr ◽  
Colin Solomon
Keyword(s):  
Physical Activity ◽  
Telomere Length ◽  
Endurance Exercise ◽  
Dna Sequences ◽  
Quantitative Polymerase Chain Reaction ◽  
Food Category ◽  
Age Related ◽  
Salivary Cell ◽  
Ultra Endurance ◽  
Age Range

BACKGROUND: Physical activity and a healthy diet may delay the aging process and ultra-endurance exercise is an extreme form of physical activity. Telomeres are protective DNA sequences located at the ends of eukaryotic chromosomes which shorten as we age. OBJECTIVE: The aim of this study was to investigate the relationships of lifetime physical activity and diet with salivary cell telomere length in current ultra-endurance exercisers (n = 49; %female = 37, age range 26–74 years). METHODS: Physical activity and dietary intake were measured using the Lifetime Physical Activity and Diet Questionnaire (LPADQ) and salivary cell telomere length was measured using quantitative polymerase chain reaction. RESULTS: In this group of current ultra-endurance exercisers there was no relationship between lifetime physical activity or diet (according to food category scores) and telomere length. In contrast to the expected age-related decrease in telomere length, there was no relationship between age and telomere length (95%confidence interval [CI]: –38.86, 14.54, p = 0.359) in this group of current ultra-endurance exercisers. CONCLUSIONS: The relationships of lifetime physical activity and diet with telomere length remain uncertain. It is possible that lifetime physical activity (including ultra-endurance exercise) and lifetime diet may independently, or in combination, contribute to a decrease in the rate of age-related telomere shortening in current ultra-endurance exercisers. ultra-endurance exercisers.

scholarly journals Telomere Length Among Older U.S. Adults: Differences by Race/Ethnicity, Gender, and Age

2016 ◽  
Vol 29 (8) ◽  
pp. 1350-1366 ◽  
Author(s):  
Lauren Brown ◽  
Belinda Needham ◽  
Jennifer Ailshire
Keyword(s):  
Older Adults ◽  
Black Women ◽  
Telomere Length ◽  
Copy Number ◽  
Quantitative Polymerase Chain Reaction ◽  
Single Gene ◽  
Gene Copy ◽  
Telomere Sequence ◽  
Gender And Age ◽  
Race Ethnicity

Objective: We examine race/ethnic, gender, and age differences in telomere length (TL) within a diverse, nationally representative sample of older adults. Method: Data come from 5,228 White, Black, and Hispanic respondents aged 54+ in the 2008 Health and Retirement Study. TL was assayed from saliva using quantitative polymerase chain reaction (qPCR) by comparing telomere sequence copy number with a single gene copy number (T/S ratio). Linear regression was used to examine TL by race/ethnicity, gender, and age adjusting for social, economic, and health characteristics. Results: Women had longer TL than men (p < .05). Blacks ( p < .05) and Hispanics ( p < .10) had longer TL than Whites. Black women and men had the longest TL relative to other groups ( p < .05), while White men had the shortest TL ( p < .05). Black women and Hispanic men showed greater differences in TL with age. Discussion: Findings indicate social patterns in TL by race/ethnicity, gender, and age among older adults do not reflect differences observed in most population health outcomes.

scholarly journals Telomere length in peripheral blood lymphocytes related to genetic variation in telomerase, prognosis and clinicopathological features in breast cancer patients

Mutagenesis ◽  
2020 ◽  
Author(s):  
Michal Kroupa ◽  
Sivaramakrishna Rachakonda ◽  
Veronika Vymetalkova ◽  
Kristyna Tomasova ◽  
Vaclav Liska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Telomere Length ◽  
Peripheral Blood ◽  
Quantitative Polymerase Chain Reaction ◽  
Peripheral Blood Lymphocytes ◽  
Clinicopathological Features ◽  
Genome Wide Association Studies ◽  
Healthy Controls ◽  
Blood Lymphocytes ◽  
Potential Biomarker

Abstract Disruption of telomere length (TL) homeostasis in peripheral blood lymphocytes has been previously assessed as a potential biomarker of breast cancer (BC) risk. The present study addressed the relationship between lymphocyte TL (LTL), prognosis and clinicopathological features in the BC patients since these associations are insufficiently explored at present. LTL was measured in 611 BC patients and 154 healthy controls using the monochrome multiplex quantitative Polymerase Chain Reaction assay. In addition, we genotyped nine TL-associated single-nucleotide polymorphisms that had been identified through genome-wide association studies. Our results showed that the patients had significantly (P = 0.001, Mann–Whitney U-test) longer LTL [median (interquartile range); 1.48 (1.22–1.78)] than the healthy controls [1.27 (0.97–1.82)]. Patients homozygous (CC) for the common allele of hTERT rs2736108 or the variant allele (CC) of hTERC rs16847897 had longer LTL. The latter association remained statistically significant in the recessive genetic model after the Bonferroni correction (P = 0.004, Wilcoxon two-sample test). We observed no association between LTL and overall survival or relapse-free survival of the patients. LTL did not correlate with cancer staging based on Union for International Cancer Control (UICC), The tumor node metastasis (TNM) staging system classification, tumour grade or molecular BC subtypes. Overall, we observed an association between long LTL and BC disease and an association of the hTERC rs16847897 CC genotype with increased LTL. However, no association between LTL, clinicopathological features and survival of the patients was found.

Alcohol consumption and physical activity among healthcare workers

2016 ◽  
Vol 6 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Francesca Montali ◽  
Giovanna Campaniello ◽  
Simona Fontechiari ◽  
Mariangela Ferrari ◽  
Pietro Vitali
Keyword(s):  
Physical Activity ◽  
Alcohol Consumption ◽  
Healthcare Workers

NESTORE Ontology: a Multi-Domain Semantic Tool for the Characterization of Older Adults Status and Behaviour to Promote Healthy Ageing by IoT Systems (Preprint)

2020 ◽  
Author(s):  
Alfonso Mastropietro ◽  
Filippo Palumbo ◽  
Silvia Orte ◽  
Michele Girolami ◽  
Francesco Furfari ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Mental Status ◽  
Scientific Knowledge ◽  
Social Behaviour ◽  
Physical Activity Behaviour ◽  
Healthy Ageing ◽  
Physiological Status ◽  
Ageing Population ◽  
Activity Behaviour

BACKGROUND The constant progression in number and share of the ageing population will likely have deep effects in most of the industrialized countries. The Internet of Things (IoT) paradigm can play a key role in facilitating independent living of the ageing population thus trying to reduce the burden on the society. Considering that ageing is a multi-factorial physiological process, the development of novel IoT systems, tools and devices, specifically targeted to older people, must be based on a holistic framework built on robust scientific knowledge in different scientific domains. OBJECTIVE A novel semantic formalization was developed, based on a multidomain healthy ageing model, to support structuring and standardizing heterogeneous scientific knowledge about ageing. The main aim of the paper is to present the new NESTORE ontology, with the purpose thus extending the available ontologies provided by universAAL-IoT (uAAL-IoT). METHODS Well-assessed scientific knowledge, specifically selected to target older adults aged between 65 and 75, was formalized into a holistic model using a multi-domain approach including three main different dimensions related to well-being: (i) Physiological Status and Physical Activity Behaviour, (ii) Nutrition, and (iii) Cognitive and Mental Status and Social Behaviour. Based on this model, within the NESTORE H2020 project, a new ontology was developed in the uAAL-IoT framework, which provides modelling tools and a set of core ontologies. RESULTS The NESTORE ontologies cover all the needed concepts to represent 5 significant domains of ageing. In total, 12 sub-ontologies were modelled with more than 60 classes and sub-classes referenced among them by using more than 100 relations and around 20 enumerations. NESTORE increases the uAAL ontologies collection by 40% and expand the uAAL domain usage for Physiological Status and Physical Activity Behaviour (8 ontologies), Nutrition (3 ontologies) and Cognitive and Mental Status and Social Behaviour (4 ontologies). CONCLUSIONS NESTORE ontology provides innovation both in terms of semantic content and technological approach. The thoroughly use of this ontology can support the development of a decision support system, to promote healthy ageing, with the capacity to do dynamic multi-scale modelling of user-specific data based on the semantic annotations of users’ profile.

scholarly journals Epidemiology of hypertension in selected towns of Wollega zones, Western Ethiopia, 2019: A community-based cross-sectional study

2021 ◽  
Vol 9 ◽  
pp. 205031212110245
Author(s):  
Getu Mosisa ◽  
Bikila Regassa ◽  
Bayise Biru
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Alcohol Consumption ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Cross Sectional Study ◽  
Care Providers ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional

Introduction: Hypertension remains an emerging public health problem globally, particularly in developing countries. Age, income level, obesity, alcohol consumption, smoking, vegetables and fruit consumption, physical activity and chat chewing were some risk factors of hypertension. However, there are limited data on the epidemiology of hypertension in Ethiopia. This study aimed to assess Epidemiology of Hypertension among the community of selected towns of Wollega zones. Methods: A community-based cross-sectional study was conducted from 1 to 30 June 2019 in selected towns of Wollega zones. A multistage sampling technique was used to select 840 study participants. Data were collected using the WHO STEP wise approach. The data were coded and entered into EpiData 3, and exported to SPSS version 20.0 for analysis. Bivariate and multivariable logistic regression analyses were conducted. Statistical significance was declared at p-value < 0.05. Results: The study included a total of 838 respondents with a response rate of 99.7%. The prevalence of hypertension was found to be 189 (22.6%) (95% confidence interval = 19.9%–25.2%). Of this, 108 (12.9%) and 81 (9.7%) of female and male were hypertensive, respectively. Age groups of 30–44 years (adjusted odds ratio = 2.65 (1.43, 4.89)), 45–59 years (adjusted odds ratio = 3.55 (1.79, 7.04)), above 60 years (adjusted odds ratio = 2.97 (1.43, 6.18)), having history of alcohol consumption (adjusted odds ratio = 4.29 (2.4, 7.66)), involving in vigorous physical activity (adjusted odds ratio = 0.096 (0.028, 0.33)), not walking to and from the work (adjusted odds ratio = 13.12 (8.34, 20.67)), being overweight (adjusted odds ratio = 1.98 (1.21, 3.25)), inadequate fruits serving per day (adjusted odds ratio = 2.93 (1.75, 4.88)) were significantly associated with hypertension. Conclusion: The prevalence of hypertension was found to be high in the study area. Older age, alcohol consumption, not engaging in vigorous activity, physical inactivity, being overweight and inadequate intake of fruits were found to be risk factors for hypertension. Therefore, health care providers should provide extensive health education and promotion on recommended lifestyle modification to tackle the burden of hypertension.

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