scholarly journals Nutritional supplementation of elderly hip fracture patients. A randomized, double-blind, placebo-controlled trial

2000 ◽  
Vol 29 (5) ◽  
pp. 425-431 ◽  
Author(s):  
J Espaulella
Keyword(s):  
Hip Fracture ◽  
Controlled Trial ◽  
Nutritional Supplementation ◽  
Double Blind ◽  
Double Blind Placebo

Reducing Aggressive Incidents Among Chronically Admitted Psychiatric Patients Through Nutritional Supplementation: A Randomized Double-Blind, Placebo-Controlled Trial

2020 ◽  
Vol 87 (9) ◽  
pp. S329
Author(s):  
Nienke de Bles ◽  
Nathaly Rius Ottenheim ◽  
Johanna M. Geleijnse ◽  
Ondine van de Rest ◽  
Albert M. van Hemert ◽  
...  
Keyword(s):  
Psychiatric Patients ◽  
Controlled Trial ◽  
Nutritional Supplementation ◽  
Double Blind ◽  
Double Blind Placebo

A Randomised, Double-Blind, Placebo-Controlled Trial of Dermatan Sulphate for Prevention of Deep Vein Thrombosis in Hip Fracture

1992 ◽  
Vol 67 (02) ◽  
pp. 203-208 ◽  
Author(s):  
Giancarlo Agnelli ◽  
Benilde Cosmi ◽  
Paolo Di Filippo ◽  
Valeria Ranucci ◽  
Franca Veschi ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Hip Fracture ◽  
Controlled Trial ◽  
Second Phase ◽  
Dermatan Sulphate ◽  
Heparin Cofactor Ii ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Vein Thrombosis ◽  
Deep Vein

SummaryDermatan sulphate (MF 701) is a natural glycosaminoglycan that catalyses thrombin inhibition by heparin cofactor II. The aim of the study was to evaluate the efficacy and safety of MF 701 for prevention of deep vein thrombosis (DVT) in patients with hip fracture. A randomised, double-blind, placebo-controlled design was used to assess two dose regimens of MF 701 in two consecutive study phases. Treatment was started within 48 h from the trauma and continued for 14 days for non-operated patients or until the 10th postoperative day. Bilateral mandatory venography was used to assess the end-point. Eighty patients were included in the first phase (40 MF 701, 40 placebo). MF 701, 100 mg IM b. i. d., did not reduce incidence of DVT from that on placebo and did not induce any bleeding. In the second phase 126 patients were included, with a randomisation ratio of 2:1 (84 MF 701, 300 mg IM b.i.d., 42 placebo). Bilateral venography was obtained for 110 patients. The incidence of DVT was 64% (23/36) in the placebo group and 38% (28/74) in the MF 701 group (p = 0.01; odds ratio [OR] = 0.34, 95% confidence limits [CL] = 0.15-0.80); proximal DVTs were 42% (15/36) and 20% (15/74), respectively (p = 0.02; OR = 0.36, CL = 0.15-0.89). No significant differences were found in haemorrhagic complications (2.4% in each group), blood loss from drains, blood transfusions, haemoglobin and haematocrit values. This study is the first demonstration that dermatan sulphate is a clinically effective antithrombotic agent without bleeding effects. It also provides evidence of the biological role of heparin cofactor II.

scholarly journals Nutritional Supplementation in Elderly Medical In-patients: A Double-blind Placebo-controlled Trial

1996 ◽  
Vol 25 (6) ◽  
pp. 453-457 ◽  
Author(s):  
M. B. HOGARTH ◽  
P. MARSHALL ◽  
L. B. LOVAT ◽  
A. J. PALMER ◽  
C. G FROST ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Nutritional Supplementation ◽  
Double Blind ◽  
Double Blind Placebo
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