scholarly journals Chromatin role in early programming of embryos

2021 ◽  
Vol 11 (6) ◽  
pp. 57-65 ◽  
Author(s):  
Mariana Priotto de Macedo ◽  
Werner Giehl Glanzner ◽  
Karina Gutierrez ◽  
Vilceu Bordignon
Keyword(s):  
Early Programming

scholarly journals Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1359
Author(s):  
Jessica Tozour ◽  
Francine Hughes ◽  
Arnaud Carrier ◽  
Didier Vieau ◽  
Fabien Delahaye
Keyword(s):  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Cellular Stress ◽  
World Health ◽  
Metabolic Dysfunction ◽  
Early Programming ◽  
Established Risk Factor ◽  
Glucose Exposure ◽  
Glycemic Memory ◽  
Health Organization

Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction passed from one generation to another. Metabolic diseases are complex and caused by the interplay between genetic and environmental factors. High-glucose exposure during in utero development, as observed with gestational diabetes mellitus (GDM), is an established risk factor for metabolic diseases. Despite intense efforts to better understand this phenomenon of early memory little is known about the molecular mechanisms associating early exposure to long-term diseases risk. However, evidence promotes glucose associated oxidative stress as one of the molecular mechanisms able to influence susceptibility to metabolic diseases. Thus, we decided here to further explore the relationship between early glucose exposure and cellular stress in the context of early development, and focus on the concept of glycemic memory, its consequences, and sexual dimorphic and epigenetic aspects.

Little Evidence for Early Programming of Weight and Insulin Resistance for Contemporary Children: EarlyBird Diabetes Study Report 19

PEDIATRICS ◽  
2006 ◽  
Vol 118 (3) ◽  
pp. 1118-1123 ◽  
Author(s):  
A. N. Jeffery ◽  
B. S. Metcalf ◽  
J. Hosking ◽  
M. J. Murphy ◽  
L. D. Voss ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Study Report ◽  
Early Programming
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