scholarly journals The Role of the Gut Microbiome in Predicting Response to Diet and the Development of Precision Nutrition Models—Part I: Overview of Current Methods

2019 ◽  
Vol 10 (6) ◽  
pp. 953-978 ◽  
Author(s):  
Riley L Hughes ◽  
Maria L Marco ◽  
James P Hughes ◽  
Nancy L Keim ◽  
Mary E Kable

ABSTRACT Health care is increasingly focused on health at the individual level. In the rapidly evolving field of precision nutrition, researchers aim to identify how genetics, epigenetics, and the microbiome interact to shape an individual's response to diet. With this understanding, personalized responses can be predicted and dietary advice can be tailored to the individual. With the integration of these complex sources of data, an important aspect of precision nutrition research is the methodology used for studying interindividual variability in response to diet. This article stands as the first in a 2-part review of current research investigating the contribution of the gut microbiota to interindividual variability in response to diet. Part I reviews the methods used by researchers to design and carry out such studies as well as the statistical and bioinformatic methods used to analyze results. Part II reviews the findings of these studies, discusses gaps in our current knowledge, and summarizes directions for future research. Taken together, these reviews summarize the current state of knowledge and provide a foundation for future research on the role of the gut microbiome in precision nutrition.

2019 ◽  
Vol 10 (6) ◽  
pp. 979-998 ◽  
Author(s):  
Riley L Hughes ◽  
Mary E Kable ◽  
Maria Marco ◽  
Nancy L Keim

ABSTRACT The gut microbiota is increasingly implicated in the health and metabolism of its human host. The host's diet is a major component influencing the composition and function of the gut microbiota, and mounting evidence suggests that the composition and function of the gut microbiota influence the host's metabolic response to diet. This effect of the gut microbiota on personalized dietary response is a growing focus of precision nutrition research and may inform the effort to tailor dietary advice to the individual. Because the gut microbiota has been shown to be malleable to some extent, it may also allow for therapeutic alterations of the gut microbiota in order to alter response to certain dietary components. This article is the second in a 2-part review of the current research in the field of precision nutrition incorporating the gut microbiota into studies investigating interindividual variability in response to diet. Part I reviews the methods used by researchers to design and carry out such studies as well as analyze the results subsequently obtained. Part II reviews the findings of these studies and discusses the gaps in our current knowledge and directions for future research. The studies reviewed provide the current understanding in this field of research and a foundation from which we may build, utilizing and expanding upon the methods and results they present to inform future studies.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Gunnar Birkelund

PurposeThe purpose of this study is to further paradox research at the individual level through applying a framework of three phases of individual response to paradox – recognition, understanding and behaviour.Design/methodology/approachCritical and integrative review of previous studies of individual responses to paradox.FindingsThe role of individual understanding is limited in extant research on individual responses to paradox. Individual understanding tends to be equated with behaviour, and thus knowledge of understanding is not differentiated enough, neither is the link between understanding and behaviour sufficiently developed.Research limitations/implicationsThe review does not consider the relationship to interactional, organisational and environmental contexts. The recommendation for future research is to explore individual responses to paradox more entirely, to provide an adequate ground for extending paradox theory across individual and broader levels of analysis.Originality/valueThe review contributes to paradox theory by separating individual understanding and then providing a framework in which recognition, understanding and behaviour can be reintegrated in new ways. In addition to more accurate discernment of individual understanding and of combinations of responses across phases, the three-phase framework facilitates investigation of more intricate influences across phases and paths of evolution of such responses over time.


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Babs Broekema ◽  
Menno Fenger ◽  
Jeroen van der Waal

PurposeThis article aims to explore whether and how economic, political and demographic municipal conditions shape citizens' attitudes regarding decentralised social policies.Design/methodology/approachThe authors analysed the 2018 wave of the Dutch Local Election Studies, which includes a novel survey item asking respondents whether they prefer local social policies to be primarily: (1) protection-based, (2) cohesion-building or (3) activation-based. The authors appended context indicators to that survey and performed multilevel logistic regression analyses (1,913 respondents nested in 336 municipalities).FindingsAt the individual level, these preferences are affected by gender, age, income, education and political inclination, as expected. However, preferences towards local social policies are not shaped by local economic, demographic or political conditions. The authors discuss the implications of these findings for future research.Originality/valueBy using unique data, including a newly developed survey item, this study is the first to explore whether and how municipal conditions shape preferences regarding local welfare. Understanding those preferences is increasingly important as many Western European countries have decentralised swathes of social policies from the national to the local level in recent decades.


Author(s):  
Ondřej Dvouletý ◽  
Marko Orel

Purpose This study aims to extend the existing body of literature on the individual-level determinants of self-employed persons with (employer entrepreneurs) and without employees (solo self-employed individuals) from the perspective of four post-communist economies (i.e. Czech Republic, Hungary, Poland and Slovakia). Design/methodology/approach The methodological approach is based on the three harmonised waves (2005, 2010 and 2015) of the European Survey on Working Conditions (EWCS). Multi-variate logistic regression models are used to determine the individual-level differences among employees, solo self-employed individuals and job creators in the selected group of countries. Findings The results show significant differences among employees, solo self-employed individuals and job creators, especially when it comes to the role of age, gender, education, previous experience, number of working hours and their determination. Job creators in Visegrád countries have, on average, more years of experience, and higher levels of education (tertiary), than wage-employees. Research limitations/implications This study provides a series of recommendations for future research on the role of family- and household-related characteristics, entrepreneurship-specific education and migration background. Originality/value The previous research on individual determinants of entrepreneurial engagement in Visegrád region was mainly based on the data from the Global Entrepreneurship Monitor. This study offers a novel perspective based on the EWCS data.


2019 ◽  
Vol 10 (4) ◽  
pp. 355-381
Author(s):  
Anuja Akhouri ◽  
Richa Chaudhary

Purpose This paper aims to review the available academic literature on CSR from employees’ perspective, with an objective to better understand the individual-level analysis of CSR and clarify the current state of thinking in the area. Specifically, the authors present the evolution of the concept of CSR, from the historical overview to the emergence of recent theory and conceptualizations; the underlying theoretical foundations of CSR; the studied variables for CSR; and the research gaps and future work avenues in the field of CSR. Design/methodology/approach In all, 158 articles from 72 journals were included in the review, and a comprehensive analysis of the reviewed articles was performed. Findings This paper makes a significant contribution to the literature by presenting a comprehensive review of the articles published in academic journals, focusing on employees’ perspective of CSR. The findings advance the understanding of the research trend in employee-focused micro-level CSR research. They will assist organizations better understand “why,” “how” and “when” employees react to CSR initiatives of an organization. This paper also identifies the existing gaps in employee-centric CSR research, which will provide important directions for future research in the area. Research limitations/implications The review focused exclusively on journal publications. Dissertations, conference papers, working papers and practitioner papers were excluded, as they are not peer-reviewed. Originality/value This paper is one of the comprehensive review papers that focus exclusively on employees’ perspective of CSR, by analyzing 158 articles from the period 1961-2017.


2018 ◽  
Vol 19 (2) ◽  
pp. 120-139
Author(s):  
V Venkatanagarajan ◽  
TJ Kamalanabhan

The positive core construct of psychological capital (PsyCap) continues to garner a great deal of enduring heed from academicians and practitioners alike. While studies have continually been attesting to PsyCap’s positive influence on job performance, there is an obvious silence in the literature as to the cross-cultural implications for PsyCap formation and management. Besides, little is known about the underlying mechanisms and the team-level boundary conditions of the PsyCap–job performance relationship. Addressing these gaps, this article speculates a blend of ancient Indian and contemporary Western psychological perspectives. In particular, we theorize the role of trigunas (three trait-like components namely sattwa, rajas and tamas) on PsyCap formation, the mediating role of organization-based self-esteem (OBSE) in the PsyCap–job performance relationship and the moderating role of supervisors’ authentic leadership behaviour in the relationship between trigunas, PsyCap, OBSE and job performance of their followers at the individual level. Research propositions based on the proposed conceptual model are presented. Implications of such a conceptual blend for cross-cultural management and future research directions conclude the article.


Author(s):  
W. Lee

In today’s global environment, a myriad of communication mechanisms enable cultures around the world to interact with one another and form complex interrelationships. The goal of this chapter is to illustrate an individual-based approach to understanding cultural similarities and differences in the borderless world. Within the context of Web communication, a typology of individual cultural value orientations is proposed. This conceptualization emphasizes the need for making distinctions first at the individual level, before group-level comparisons are meaningful, in order to grasp the complexity of today’s global culture. The empirical study reported here further demonstrates the usefulness of this approach by successfully identifying 16 groups among American Web users as postulated in the proposed typology. Future research should follow the implications provided in this chapter in order to broaden our thinking about the role of culture in a world of global communication.


2008 ◽  
pp. 2056-2072
Author(s):  
Wei-Na Lee ◽  
Sejung Marina Choi

In today’s global environment, a myriad of communication mechanisms enable cultures around the world to interact with one another and form complex interrelationships. The goal of this chapter is to illustrate an individual-based approach to understanding cultural similarities and differences in the borderless world. Within the context of Web communication, a typology of individual cultural value orientations is proposed. This conceptualization emphasizes the need for making distinctions first at the individual level, before group-level comparisons are meaningful, in order to grasp the complexity of today’s global culture. The empirical study reported here further demonstrates the usefulness of this approach by successfully identifying 16 groups among American Web users as postulated in the proposed typology. Future research should follow the implications provided in this chapter in order to broaden our thinking about the role of culture in a world of global communication.


Author(s):  
Wei-Na Lee

In today’s global environment, a myriad of communication mechanisms enable cultures around the world to interact with one another and form complex interrelationships. The goal of this chapter is to illustrate an individual-based approach to understanding cultural similarities and differences in the borderless world. Within the context of Web communication, a typology of individual cultural value orientations is proposed. This conceptualization emphasizes the need for making distinctions first at the individual level, before group-level comparisons are meaningful, in order to grasp the complexity of today’s global culture. The empirical study reported here further demonstrates the usefulness of this approach by successfully identifying 16 groups among American Web users as postulated in the proposed typology. Future research should follow the implications provided in this chapter in order to broaden our thinking about the role of culture in a world of global communication.


The Oxford Handbook of the Auditory Brainstem provides an in-depth reference to the organization and function of ascending and descending auditory pathways in the mammalian brainstem. Individual chapters are organized along the auditory pathway, beginning with the cochlea and ending with the auditory midbrain. Each chapter provides an introduction to the respective area and summarizes our current knowledge before discussing the disputes and challenges that the field currently faces.The handbook emphasizes the numerous forms of plasticity that are increasingly observed in many areas of the auditory brainstem. Several chapters focus on neuronal modulation of function and plasticity on the synaptic, neuronal, and circuit level, especially during development, aging, and following peripheral hearing loss. In addition, the book addresses the role of trauma-induced maladaptive plasticity with respect to its contribution in generating central hearing dysfunction, such as hyperacusis and tinnitus.The book is intended for students and postdoctoral fellows starting in the auditory field and for researchers of related fields who wish to get an authoritative and up-to-date summary of the current state of auditory brainstem research. For clinical practitioners in audiology, otolaryngology, and neurology, the book is a valuable resource of information about the neuronal mechanisms that are currently discussed as major candidates for the generation of central hearing dysfunction.


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