Notes on two function models

1986 ◽  
pp. 113-141 ◽  
Author(s):  
N. Nikol’skiĭ ◽  
V. Vasyunin
Keyword(s):  
Function Models

scholarly journals Brain mast cells link the immune system to anxiety-like behavior

2008 ◽  
Vol 105 (46) ◽  
pp. 18053-18057 ◽  
Author(s):  
Katherine M. Nautiyal ◽  
Ana C. Ribeiro ◽  
Donald W. Pfaff ◽  
Rae Silver
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Activation ◽  
Mast Cell Activation ◽  
Neural Systems ◽  
Loss Of Function ◽  
Littermate Control ◽  
Cytokines And Chemokines ◽  
Function Models ◽  
The Brain

Mast cells are resident in the brain and contain numerous mediators, including neurotransmitters, cytokines, and chemokines, that are released in response to a variety of natural and pharmacological triggers. The number of mast cells in the brain fluctuates with stress and various behavioral and endocrine states. These properties suggest that mast cells are poised to influence neural systems underlying behavior. Using genetic and pharmacological loss-of-function models we performed a behavioral screen for arousal responses including emotionality, locomotor, and sensory components. We found that mast cell deficient KitW−sh/W−sh (sash−/−) mice had a greater anxiety-like phenotype than WT and heterozygote littermate control animals in the open field arena and elevated plus maze. Second, we show that blockade of brain, but not peripheral, mast cell activation increased anxiety-like behavior. Taken together, the data implicate brain mast cells in the modulation of anxiety-like behavior and provide evidence for the behavioral importance of neuroimmune links.

scholarly journals A Simple Transient Poiseuille-Based Approach to Mimic the Womersley Function and to Model Pulsatile Blood Flow

Dynamics ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 9-17
Author(s):  
Andrea Natale Impiombato ◽  
Giorgio La Civita ◽  
Francesco Orlandi ◽  
Flavia Schwarz Franceschini Zinani ◽  
Luiz Alberto Oliveira Rocha ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Blood Flow ◽  
Boundary Conditions ◽  
Quadratic Function ◽  
Pulsatile Blood Flow ◽  
Flow Through ◽  
Simplified Analysis ◽  
Function Models ◽  
Flow Reversals

As it is known, the Womersley function models velocity as a function of radius and time. It has been widely used to simulate the pulsatile blood flow through circular ducts. In this context, the present study is focused on the introduction of a simple function as an approximation of the Womersley function in order to evaluate its accuracy. This approximation consists of a simple quadratic function, suitable to be implemented in most commercial and non-commercial computational fluid dynamics codes, without the aid of external mathematical libraries. The Womersley function and the new function have been implemented here as boundary conditions in OpenFOAM ESI software (v.1906). The discrepancy between the obtained results proved to be within 0.7%, which fully validates the calculation approach implemented here. This approach is valid when a simplified analysis of the system is pointed out, in which flow reversals are not contemplated.

scholarly journals Up-regulation of long non-coding RNA CYTOR induced by icariin promotes the viability and inhibits the apoptosis of chondrocytes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Guoyou Wang ◽  
Lei Zhang ◽  
Huarui Shen ◽  
Qi Hao ◽  
Shijie Fu ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Inflammatory Factors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Protective Effects ◽  
Loss Of Function ◽  
Protective Function ◽  
Non Coding Rna ◽  
Effective Component ◽  
Short Hairpin Rnas ◽  
Function Models

Abstract Background Icariin (ICAR) is the main effective component extracted from epimedium, and is reported to have the potential to treat osteoarthritis (OA). However, its pharmacological function on chondrocytes has not been fully clarified. Methods Different doses of ICAR were used to treat chondrocyte cell lines, including CHON-001 and ATDC5. Then the expressions of different lncRNAs were measured by qRT-PCR. Interleukin-1β (IL-1β) was used to simulate the inflammatory response environment of chondrocytes. Overexpression plasmids and short hairpin RNAs of lncRNA CYTOR were used to construct gain-of-function and loss of function models. CCK-8 was conducted to determine the cell viability. Flow cytometry was used to detect the apoptosis of chondrocytes. Enzyme-linked immunosorbent assay (ELISA) was adopted to measure the contents of inflammatory factors (IL-6, IL-8, TNF-α) in the supernatant of the chondrocytes. Results Compared with other lncRNAs, CYTOR was changed most significantly in both CHON-001 and ATDC5 cells after treatment with ICAR. ICAR promotes the viability and inhibits the apoptosis of CHON-001 and ATDC5 cells induced by IL-1β, accompanied with reduced levels of inflammatory factors. Overexpression of CYTOR facilitated the viability of chondrocytes, while repressed their apoptosis and inflammatory response. What’s more, knockdown of CYTOR reversed the protective effects of ICAR on chondrocytes. Conclusion CYTOR was a pivotal lncRNA involved in the protective function of ICAR on chondrocytes.

Feed forward neural network and interpolation function models to predict the soil and subsurface sediments distribution in Bam, Iran

2009 ◽  
Vol 57 (2) ◽  
pp. 271-293 ◽  
Author(s):  
Khalil Rezaei ◽  
Bernard Guest ◽  
Anke Friedrich ◽  
Farajollah Fayazi ◽  
Muhammad Nakhaei ◽  
...  
Keyword(s):  
Neural Network ◽  
Interpolation Function ◽  
Feed Forward Neural Network ◽  
Feed Forward ◽  
Subsurface Sediments ◽  
Function Models
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