In this paper we develop methods for classifying Baker, Richter, and Szymik's Azumaya algebras over a commutative ring spectrum, especially in the largely inaccessible case where the ring is nonconnective. We give obstruction-theoretic tools, constructing and classifying these algebras and their automorphisms with Goerss–Hopkins obstruction theory, and give descent-theoretic tools, applying Lurie's work on
$\infty$
-categories to show that a finite Galois extension of rings in the sense of Rognes becomes a homotopy fixed-point equivalence on Brauer spaces. For even-periodic ring spectra
$E$
, we find that the ‘algebraic’ Azumaya algebras whose coefficient ring is projective are governed by the Brauer–Wall group of
$\pi _0(E)$
, recovering a result of Baker, Richter, and Szymik. This allows us to calculate many examples. For example, we find that the algebraic Azumaya algebras over Lubin–Tate spectra have either four or two Morita equivalence classes, depending on whether the prime is odd or even, that all algebraic Azumaya algebras over the complex K-theory spectrum
$KU$
are Morita trivial, and that the group of the Morita classes of algebraic Azumaya algebras over the localization
$KU[1/2]$
is
$\mathbb {Z}/8\times \mathbb {Z}/2$
. Using our descent results and an obstruction theory spectral sequence, we also study Azumaya algebras over the real K-theory spectrum
$KO$
which become Morita-trivial
$KU$
-algebras. We show that there exist exactly two Morita equivalence classes of these. The nontrivial Morita equivalence class is realized by an ‘exotic’
$KO$
-algebra with the same coefficient ring as
$\mathrm {End}_{KO}(KU)$
. This requires a careful analysis of what happens in the homotopy fixed-point spectral sequence for the Picard space of
$KU$
, previously studied by Mathew and Stojanoska.
Morita equivalence classes of $2$-blocks of defect three