scholarly journals Sequence alignment in molecular biology

1999 ◽  
pp. 85-115 ◽  
Author(s):  
Alberto Apostolico ◽  
Raffaele Giancarlo
Keyword(s):  
Molecular Biology ◽  
Sequence Alignment

scholarly journals Formulation and Analysis of Patterns in a Score Matrix for Global Sequence Alignment

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
James Owusu Asare ◽  
Justice Kwame Appati ◽  
Kwaku Darkwah
Keyword(s):  
Dynamic Programming ◽  
Molecular Biology ◽  
Sequence Alignment ◽  
A Priori ◽  
Dynamic Programming Algorithm ◽  
Evolutionary Relationship ◽  
Programming Algorithm ◽  
Pairwise Sequence Alignment ◽  
Score Matrix ◽  
Unequal Length

Global sequence alignment is one of the most basic pairwise sequence alignment procedures used in molecular biology to understand the similarity that arises among the structure, function, or evolutionary relationship between two nucleotide sequences. The general algorithm associated with global sequence alignment is the dynamic programming algorithm of Needleman and Wunsch. In this paper, patterns are exploited in the score matrix of the Needleman–Wunsch algorithm. With the help of some examples, the general patterns realized are formulated as new a priori propositions and corollaries that are established for both equal and unequal length comparisons of any two arbitrary sequences.

scholarly journals Sequence Alignment in Molecular Biology

1998 ◽  
Vol 5 (2) ◽  
pp. 173-196 ◽  
Author(s):  
ALBERTO APOSTOLICO ◽  
RAFFAELE GIANCARLO
Keyword(s):  
Molecular Biology ◽  
Sequence Alignment

scholarly journals VSA-TOOL: A TOOL FOR DATA VISUALIZATION IN SEQUENCE ALIGNMENT

2004 ◽  
Vol 16 (02) ◽  
pp. 68-72
Author(s):  
LI-YEH CHUANG ◽  
CHENG-HONG YANG ◽  
CHAO-CHING CHANG ◽  
WEN-SHYONG TZOU ◽  
LI-CHENG JIN
Keyword(s):  
Data Analysis ◽  
Molecular Biology ◽  
Data Visualization ◽  
Sequence Alignment ◽  
Similarity Search ◽  
Sequence Data ◽  
Protein Sequences ◽  
Interactive System ◽  
And Function ◽  
Similarity Pattern

Sequence alignment is a fundamental and important tool for sequence data analysis in molecular biology. Many applications in molecular biology require the detection of a similarity pattern displayed by a number of DNA and protein sequences. Visual front-ends are useful for an intuitive viewing of alignment and help to analyze the structure, functions, and evolution of the DNA and protein. In this paper, we designed and implemented an interactive system for data visualization in DNA and proteins, which can be used in determining a sequence alignment, similarity search of sequence data, and function interference. Experimental results show that a user can easily operate the system after one hour's practice on the proposed system, which provides a clean output, easy identification of similarity and visualization of alignment data.

Electron Microscopy in Molecular Biology

1967 ◽  
Vol 25 ◽  
pp. 2-3
Author(s):  
Cecil E. Hall
Keyword(s):  
Electron Microscopy ◽  
Molecular Biology ◽  
Noise Level ◽  
Molecular Structures ◽  
Material Structure ◽  
The Arts ◽  
Shadow Casting ◽  
Electron Image ◽  
High Degree ◽  
Very High

The visualization of organic macromolecules such as proteins, nucleic acids, viruses and virus components has reached its high degree of effectiveness owing to refinements and reliability of instruments and to the invention of methods for enhancing the structure of these materials within the electron image. The latter techniques have been most important because what can be seen depends upon the molecular and atomic character of the object as modified which is rarely evident in the pristine material. Structure may thus be displayed by the arts of positive and negative staining, shadow casting, replication and other techniques. Enhancement of contrast, which delineates bounds of isolated macromolecules has been effected progressively over the years as illustrated in Figs. 1, 2, 3 and 4 by these methods. We now look to the future wondering what other visions are waiting to be seen. The instrument designers will need to exact from the arts of fabrication the performance that theory has prescribed as well as methods for phase and interference contrast with explorations of the potentialities of very high and very low voltages. Chemistry must play an increasingly important part in future progress by providing specific stain molecules of high visibility, substrates of vanishing “noise” level and means for preservation of molecular structures that usually exist in a solvated condition.

An introduction to the themed issue on RNA biology in China

2020 ◽  
Vol 64 (6) ◽  
pp. 863-866
Author(s):  
Zhe Wu
Keyword(s):  
Molecular Biology ◽  
Chinese Society ◽  
Fortieth Anniversary ◽  
Rna Biology ◽  
Research And Education ◽  
Education In China

Abstract The year 2019 marked the fortieth anniversary of the Chinese Society of Biochemistry and Molecular Biology (CSBMB), whose mission is to promote biomolecular research and education in China. The last 40 years have witnessed tremendous growth and achievements in biomolecular research by Chinese scientists and Essays in Biochemistry is delighted to publish this themed issue that focuses on exciting areas within RNA biology, with each review contributed by key experts from China.

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