Upper and lower value of games of fixed duration

2005 ◽  
pp. 9-12
Keyword(s):  
Fixed Duration

4-Jahres-Update der Murano-Studie bestätigt den Stellenwert von Venetoclax in der 2. Therapielinie der CLL

2021 ◽  
pp. 77-79
Author(s):  
Maximilian Schmutz ◽  
Sebastian Sommer
Keyword(s):  
Response Rate ◽  
Residual Disease ◽  
Gene Mutations ◽  
Progression Free Survival ◽  
Lymphocytic Leukemia ◽  
Fixed Duration ◽  
Genetic Characteristics ◽  
Genomic Complexity ◽  
End Of Treatment

<b>Purpose:</b> In previous analyses of the MURANO study, fixed-duration venetoclax plus rituximab (VenR) resulted in improved progression-free survival (PFS) compared with bendamustine plus rituximab (BR) in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). At the 4-year follow-up, we report long-term outcomes, response to subsequent therapies, and the predictive value of molecular and genetic characteristics. <b>Patients and methods:</b> Patients with CLL were randomly assigned to 2 years of venetoclax (VenR for the first six cycles) or six cycles of BR. PFS, overall survival (OS), peripheral-blood minimal residual disease (MRD) status, genomic complexity (GC), and gene mutations were assessed. <b>Results:</b> Of 389 patients, 194 were assigned to VenR and 195 to BR. Four-year PFS and OS rates were higher with VenR than BR, at 57.3% and 4.6% (hazard ratio [HR], 0.19; 95% CI, 0.14 to 0.25), and 85.3% and 66.8% (HR, 0.41; 95% CI, 0.26 to 0.65), respectively. Undetectable MRD (uMRD) at end of combination therapy (EOCT) was associated with superior PFS compared with low MRD positivity (HR, 0.50) and high MRD positivity (HR, 0.15). Patients in the VenR arm who received ibrutinib as their first therapy after progression (n = 12) had a reported response rate of 100% (10 of 10 evaluable patients); patients subsequently treated with a venetoclax-based regimen (n = 14) had a reported response rate of 55% (six of 11 evaluable patients). With VenR, the uMRD rate at end of treatment (EOT) was lower in patients with GC than in those without GC (<i>P</i> = 0.042); higher GC was associated with shorter PFS. Higher MRD positivity rates were seen with <i>BIRC3</i> and <i>BRAF</i> mutations at EOCT and with <i>TP53, NOTCH1, XPO1,</i> and <i>BRAF</i> mutations at EOT. <b>Conclusion:</b> Efficacy benefits with fixed-duration VenR are sustained and particularly durable in patients who achieve uMRD. Salvage therapy with ibrutinib after VenR achieved high response rates. Genetic mutations and GC affected MRD rates and PFS. <b>Trial registration:</b> ClinicalTrials.gov NCT02005471.

scholarly journals Constancy of the optimum temperature of an enzyme under varying concentrations of substrate and of enzyme

1914 ◽  
Vol 88 (602) ◽  
pp. 258-262
Keyword(s):  
Experimental Evidence ◽  
Aspergillus Oryzae ◽  
Hydrolytic Enzyme ◽  
Fixed Duration ◽  
Optimum Temperature ◽  
Enzymic Hydrolysis ◽  
Main Interest ◽  
General Law ◽  
The Moment ◽  
Hydrolysis Of

In a recent paper a new enzymic relation is recorded. For the enzymic hydrolysis of salicin—by the enzyme which Gabriel Bertrand and the author have named salicinase —it is found that, in an action of fixed duration, the temperature of greatest activity of the ferment is always the same, whatever the dilutions of substrate and of enzyme adopted for the determination. In other words, the duration of the action being constant, the optimum tem­perature of the ferment is independent of the concentration both of the substrate and of the enzyme. The observation is suggestive: if true of one enzyme it may be true of all, and possibly becomes the enunciation of a general law. Herein, for the moment, lies its main interest. In the present paper further experimental evidence for this hypothesis in given, in the case of another hydrolytic enzyme, the maltase of Aspergillus oryzæ (taka-diastase).

Poster: IBCL-085: Assessment of Fixed-Duration Therapies for Treatment-Naïve Waldenström Macroglobulinemia

2021 ◽  
Vol 21 ◽  
pp. S244
Author(s):  
Jithma Abeykoon ◽  
Saurabh Zanwar ◽  
Stephen Ansell ◽  
Eli Muchtar ◽  
Rong He ◽  
...  
Keyword(s):  
Fixed Duration ◽  
Waldenström Macroglobulinemia ◽  
Waldenstrom Macroglobulinemia ◽  
Treatment Naïve

scholarly journals Speed-detachment tradeoff and its effect on track bound transport of single motor protein

2018 ◽  
Author(s):  
Mohd Suhail Rizvi
Keyword(s):  
Experimental Data ◽  
Random Walk ◽  
Power Law ◽  
Average Distance ◽  
Motor Protein ◽  
Fixed Duration ◽  
Biological Cells ◽  
Single Motor ◽  
Stochastic Nature ◽  
Time Required

AbstractThe transportation of the cargoes in biological cells is primarily driven by the motor proteins on filamentous protein tracks. The stochastic nature of the motion of motor protein often leads to its spontaneous detachment from the track. Using the available experimental data, we demonstrate a tradeoff between the speed of the motor and its rate of spontaneous detachment from the track. Further, it is also shown that this speed-detachment relation follows a power law where its exponent dictates the nature of the motor protein processivity. We utilize this information to study the motion of motor protein on track using a random-walk model. We obtain the average distance travelled in fixed duration and average time required for covering a given distance by the motor protein. These analyses reveal non-monotonic dependence of the motor protein speed on its transport and, therefore, optimal motor speeds can be identified for the time and distance controlled conditions.

scholarly journals Misyar Marriage between Shari`ah texts, Realities and scholars’ Fatawa’: An Analysis

IIUC Studies ◽  
2012 ◽  
Vol 7 ◽  
pp. 297-320
Author(s):  
Noor Mohammad Osmani
Keyword(s):  
Saudi Arabia ◽  
Muslim World ◽  
Mutual Understanding ◽  
Fixed Duration ◽  
Men And Women ◽  
The Real ◽  
Gulf States ◽  
Part Time ◽  
New Form ◽  
Relationship Of

Marriage is a sacred bond in Islam that ties a man and a woman into a lifelong relationship of love, compassion, mutual understanding, respect and security. It is a firm pledge that one makes in the name of Allah for one-another. ‘Misyar marriage’, ‘Convenience marriage’ or ‘Travelers’ marriage’ is a new form of marriage practiced widely in Saudi Arabia, Egypt and other gulf states. The ‘Misyar bride’ sacrifices some of her marital rights, such as expenses, fixed duration, and an abode. The scholars in Islam have different opinions about this form of marriage. Some of them supported it vehemently, as it could reduce the number of ladies without husbands; while yet others strongly oppose it, as it sounds like part-time wives, which has no roots in Islamic heritage. The present study therefore aims to explore the real status of ‘Misyar or convenience marriage’ in the texts from the Qur’an, Prophet’s Sunnah, the practices of his rightly guided Companions and the Fatawa of the traditional and modern scholars. It would analyze them in the light of the current realities and situations prevailing in many countries of the Muslim world. The study would adopt a critical yet objective approach in dealing with the issue. It is believed that the study would help the Muslim men and women to have clear insights on the issue based on the Shari`ah texts, scholars’ Fatawa and present day realities. DOI: http://dx.doi.org/10.3329/iiucs.v7i0.12495 IIUC Studies Vol.7 2011: 297-320

Trust and control in fixed duration alliances

2011 ◽  
Vol 2 (1/2) ◽  
pp. 41 ◽  
Author(s):  
Anna R.S. Sward ◽  
Randi Lunnan
Keyword(s):  
Fixed Duration ◽  
And Control

scholarly journals Fixed duration vs continuous therapy in multiple myeloma

Hematology ◽  
2017 ◽  
Vol 2017 (1) ◽  
pp. 212-222 ◽  
Author(s):  
Heinz Ludwig ◽  
Niklas Zojer
Keyword(s):  
Young Patients ◽  
Progression Free Survival ◽  
Term Treatment ◽  
New Drugs ◽  
Prolonged Treatment ◽  
Severe Toxicity ◽  
Fixed Duration ◽  
Continuous Therapy ◽  
Long Term Treatment ◽  
Risk Patients

Abstract The introduction of new drugs with less severe toxicity profiles than those of conventional antimyeloma agents allowed the evaluation of continuous therapy compared with fixed duration therapy. In transplant-eligible patients, consolidation therapy with bortezomib or bortezomib-based regimens showed significant progression-free survival (PFS) benefit in cytogenetic standard-risk patients and to a lesser extent, high-risk patients. Continuous therapy with lenalidomide maintenance treatment after autologous stem cell transplantation resulted in a significant survival gain. In transplant noneligible patients, continuous lenalidomide-dexamethasone therapy improved survival over fixed duration melphalan-prednisone-thalidomide. The concept of prolonged treatment in elderly patients is supported by some other studies, but most of them revealed a gain in PFS only. Young patients with unfavorable prognosis show a greater willingness to accept long-term treatment, whereas the readiness to undergo such treatments and the benefits therefrom decline with increasing age and decreasing fitness, rendering fixed duration therapy a suitable option in elderly frail patients.

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