scholarly journals Epstein–Barr Virus Lytic Reactivation Induces IgG4 Production by Host B Lymphocytes in Graves' Disease Patients and Controls: A Subset of Graves' Disease Is an IgG4-Related Disease-Like Condition

2018 ◽  
Vol 31 (8) ◽  
pp. 540-547 ◽  
Author(s):  
Keiko Nagata ◽  
Sayuri Hara ◽  
Yuji Nakayama ◽  
Katsumi Higaki ◽  
Hirotsugu Sugihara ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Epstein Barr Virus ◽  
Graves Disease ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Lytic Reactivation ◽  
Epstein Barr

Epstein-Barr virus in the enlarged salivary tissues of patients with IgG4-related disease

2015 ◽  
Vol 125 (9) ◽  
pp. 2079-2084 ◽  
Author(s):  
Takatoshi Furukawa ◽  
Yoshitaka Shimotai ◽  
Nobuo Ohta ◽  
Akihiro Ishida ◽  
Kazuya Kurakami ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Epstein Barr

Epstein-Barr Virus–infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease

2014 ◽  
Vol 38 (7) ◽  
pp. 946-955 ◽  
Author(s):  
Mai Takeuchi ◽  
Yasuharu Sato ◽  
Hiroshi Yasui ◽  
Hiroaki Ozawa ◽  
Kyotaro Ohno ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Infected Cells ◽  
Epstein Barr

A case of Epstein–Barr virus-related lymphadenopathy mimicking the clinical features of IgG4-related disease

2013 ◽  
Vol 23 (3) ◽  
pp. 597-603 ◽  
Author(s):  
Yoko Wada ◽  
Masaru Kojima ◽  
Kazuhiro Yoshita ◽  
Mihoko Yamazaki ◽  
Daisuke Kobayashi ◽  
...  
Keyword(s):  
Clinical Features ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Epstein Barr

scholarly journals Immunization with Epstein–Barr Virus Core Fusion Machinery Envelope Proteins Elicit High Titers of Neutralizing Activities and Protect Humanized Mice from Lethal Dose EBV Challenge

Vaccines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 285
Author(s):  
Xinle Cui ◽  
Zhouhong Cao ◽  
Yuriko Ishikawa ◽  
Sara Cui ◽  
Ken-Ichi Imadome ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
B Lymphocytes ◽  
Neutralizing Antibodies ◽  
Epstein Barr Virus ◽  
Lethal Dose ◽  
Envelope Proteins ◽  
Humanized Mice ◽  
Target Cells ◽  
Barr Virus ◽  
Epstein Barr

Epstein–Barr virus (EBV) is the primary cause of infectious mononucleosis and is strongly implicated in the etiology of multiple lymphoid and epithelial cancers. EBV core fusion machinery envelope proteins gH/gL and gB coordinately mediate EBV fusion and entry into its target cells, B lymphocytes and epithelial cells, suggesting these proteins could induce antibodies that prevent EBV infection. We previously reported that the immunization of rabbits with recombinant EBV gH/gL or trimeric gB each induced markedly higher serum EBV-neutralizing titers for B lymphocytes than that of the leading EBV vaccine candidate gp350. In this study, we demonstrated that immunization of rabbits with EBV core fusion machinery proteins induced high titer EBV neutralizing antibodies for both B lymphocytes and epithelial cells, and EBV gH/gL in combination with EBV trimeric gB elicited strong synergistic EBV neutralizing activities. Furthermore, the immune sera from rabbits immunized with EBV gH/gL or trimeric gB demonstrated strong passive immune protection of humanized mice from lethal dose EBV challenge, partially or completely prevented death respectively, and markedly decreased the EBV load in peripheral blood of humanized mice. These data strongly suggest the combination of EBV core fusion machinery envelope proteins gH/gL and trimeric gB is a promising EBV prophylactic vaccine.

scholarly journals Activated or dominant inhibitory mutants of Rap1A decrease the oxidative burst of Epstein-Barr virus-transformed human B lymphocytes.

1994 ◽  
Vol 269 (29) ◽  
pp. 18743-18746 ◽  
Author(s):  
F.E. Maly ◽  
L.A. Quilliam ◽  
O. Dorseuil ◽  
C.J. Der ◽  
G.M. Bokoch
Keyword(s):  
B Lymphocytes ◽  
Oxidative Burst ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals PARP1 restricts Epstein Barr Virus lytic reactivation by binding the BZLF1 promoter

Virology ◽  
2017 ◽  
Vol 507 ◽  
pp. 220-230 ◽  
Author(s):  
Lena N. Lupey-Green ◽  
Stephanie A. Moquin ◽  
Kayla A. Martin ◽  
Shane M. McDevitt ◽  
Michael Hulse ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Lytic Reactivation ◽  
Epstein Barr ◽  
Bzlf1 Promoter

scholarly journals Laboratory Assays for Epstein-Barr Virus-Related Disease

2008 ◽  
Vol 10 (4) ◽  
pp. 279-292 ◽  
Author(s):  
Margaret L. Gulley ◽  
Weihua Tang
Keyword(s):  
Epstein Barr Virus ◽  
Barr Virus ◽  
Related Disease ◽  
Epstein Barr
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