Induction of Both Local Immune Response in Mice and Protection in a Rabbit Model by Intranasal Immunization with Modified Vaccinia Ankara Virus Expressing a Secreted Form of Bovine Herpesvirus 1 Glycoprotein D

2017 ◽  
Vol 30 (1) ◽  
pp. 70-76 ◽  
Author(s):  
María Paula Del Medico Zajac ◽  
Flavia Adriana Zanetti ◽  
María Soledad Esusy ◽  
Carlos Rodolfo Federico ◽  
Osvaldo Zabal ◽  
...  
Keyword(s):  
Immune Response ◽  
Rabbit Model ◽  
Bovine Herpesvirus ◽  
Local Immune Response ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Intranasal Immunization ◽  
Herpesvirus 1

scholarly journals The Immunogenicity and Protective Efficacy of Bovine Herpesvirus 1 Glycoprotein D plus Emulsigen Are Increased by Formulation with CpG Oligodeoxynucleotides

2002 ◽  
Vol 76 (18) ◽  
pp. 9002-9010 ◽  
Author(s):  
X. P. Ioannou ◽  
P. Griebel ◽  
R. Hecker ◽  
L. A. Babiuk ◽  
S. van Drunen Littel-van den Hurk
Keyword(s):  
Immune Response ◽  
Neutralizing Antibodies ◽  
Protective Efficacy ◽  
Bovine Herpesvirus ◽  
Ammonium Bromide ◽  
Cpg Odn ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Cpg Oligodeoxynucleotides ◽  
Herpesvirus 1

ABSTRACT The immunogenicity and protective efficacy of a bovine herpesvirus 1 (BHV-1) subunit vaccine formulated with Emulsigen (Em) and a synthetic oligodeoxynucleotide containing unmethylated CpG dinucleotides (CpG ODN) was determined in cattle. A truncated, secreted version of BHV-1 glycoprotein D (tgD) formulated with Em and CpG ODN at concentrations of 25, 2.5, or 0.25 mg/dose produced a more balanced immune response, higher levels of virus neutralizing antibodies, and greater protection after BHV-1 challenge compared to tgD adjuvanted with either Em or CpG ODN alone. In contrast, tgD formulated with Em and either 25 mg of a non-CpG ODN or another immunostimulatory compound, dimethyl dioctadecyl ammonium bromide, induced similar immunity and protection compared to tgD formulated with Em alone, a finding which confirms the immunostimulatory effect of ODN to be CpG motif mediated. Our results demonstrate the ability of CpG ODN to induce a strong and balanced immune response in a target species.

TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1

Virology ◽  
2021 ◽  
Author(s):  
Kornuta Claudia Alejandra ◽  
Cheuquepán Felipe ◽  
Bidart Juan Esteban ◽  
Soria Ivana ◽  
Gammella Mariela ◽  
...  
Keyword(s):  
Immune Response ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Commercial Vaccine ◽  
Herpesvirus 1

scholarly journals Bovine herpesvirus 1 glycoprotein D expression in bovine upper respiratory tract mediated by a human adenovirus type 5

2004 ◽  
Vol 35 (6) ◽  
pp. 715-721 ◽  
Author(s):  
Sacha Gogev ◽  
Jean-Pierre Georgin ◽  
Fr�d�ric Schynts ◽  
Alain Vanderplasschen ◽  
Etienne Thiry
Keyword(s):  
Respiratory Tract ◽  
Bovine Herpesvirus ◽  
Human Adenovirus ◽  
Adenovirus Type ◽  
Upper Respiratory Tract ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Upper Respiratory ◽  
Herpesvirus 1 ◽  
Adenovirus Type 5

Genetic diversity of 3′ region of glycoprotein D gene of bovine herpesvirus 1 and 5

Virus Genes ◽  
2014 ◽  
Vol 48 (3) ◽  
pp. 438-447 ◽  
Author(s):  
Carolina Kist Traesel ◽  
Mariana Sá e Silva ◽  
Marcelo Weiss ◽  
Fernando Rosado Spilki ◽  
Rudi Weiblen ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Bovine Herpesvirus ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor

2020 ◽  
Vol 6 (20) ◽  
pp. eaba5147
Author(s):  
Dan Yue ◽  
Zhujun Chen ◽  
Fanli Yang ◽  
Fei Ye ◽  
Sheng Lin ◽  
...  
Keyword(s):  
Functional Data ◽  
Bovine Herpesvirus ◽  
Binding Mode ◽  
Cell Entry ◽  
Glycoprotein D ◽  
Viral Glycoprotein ◽  
Bovine Herpesvirus 1 ◽  
Receptor Recognition ◽  
Large Conformational Change ◽  
Herpesvirus 1

Bovine herpesvirus 1 (BHV-1) has received increasing attention for its potential oncolytic applications. BHV-1 recognizes nectin-1 for cell entry via viral glycoprotein D (gD) but represents a low-affinity nectin-1 binding virus. The molecular basis underlying this low receptor-binding affinity, however, remains unknown. Here, the crystal structures of BHV-1 gD in the free and nectin-1–bound forms are presented. While showing an overall resembled nectin-1 binding mode to other alphaherpesvirus gDs, BHV-1 gD has a unique G-strand/α2-helix interloop that disturbs gD/nectin-1 interactions. Residue R188 residing in this loop is observed to otherwise cause strong steric hindrance with the bound receptor, making a large conformational change of the loop a prerequisite for nectin-1 engagement. Subsequently, substitution of R188 with glycine markedly enhances the affinity of the BHV-1-gD/nectin-1 interaction (by about fivefold). These structural and functional data delineate the receptor-recognition basis for BHV-1, which might facilitate BHV-1–based oncolytic design in the future.

An Immunoenzyme Linked Assay (ELISA) for the Detection of Antibodies to Truncated Glycoprotein D (tgD) of Bovine Herpesvirus-1

2006 ◽  
Vol 30 (S1) ◽  
pp. 257-259 ◽  
Author(s):  
S. Petrini ◽  
M. Ferrari ◽  
S. Vincenzetti ◽  
A. Vita ◽  
A. Amici ◽  
...  
Keyword(s):  
Bovine Herpesvirus ◽  
Glycoprotein D ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals Immunity to Bovine Herpesvirus 1: I. Viral lifecycle and innate immunity

2013 ◽  
Vol 14 (1) ◽  
pp. 88-102 ◽  
Author(s):  
Randall L. Levings ◽  
James A. Roth
Keyword(s):  
Immune Response ◽  
Latent Infection ◽  
Bovine Herpesvirus ◽  
Lytic Replication ◽  
Host Cells ◽  
Type I Interferons ◽  
Disease Spread ◽  
Type I ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1

AbstractBovine herpesvirus 1 (BHV-1) causes a variety of diseases and is globally distributed. It infects via mucosal epithelium, leading to rapid lytic replication and latent infection, primarily in sensory ganglia. Large amounts of virus can be excreted by the host on primary infection or upon recrudescence of latent infection, resulting in disease spread. The bovine immune response to BHV-1 is rapid, robust, balanced, and long-lasting. The innate immune system is the first to respond to the infection, with type I interferons (IFNs), inflammatory cytokines, killing of infected host cells, and priming of a balanced adaptive immune response. The virus possesses a variety of immune evasion strategies, including inhibition of type I IFN production, chemokine and complement binding, infection of macrophages and neutrophils, and latency. BHV-1 immune suppression contributes to the severity of its disease manifestations and to the bovine respiratory disease complex, the leading cause of cattle death loss in the USA.

Induction of Immune Response to Bovine Herpesvirus-1 with Anti-idiotypic Antibodies

1991 ◽  
Vol 4 (2) ◽  
pp. 111-122 ◽  
Author(s):  
D.J. ORTEN ◽  
P.O. REDDY ◽  
D.N. REDDY ◽  
W. XUE ◽  
O.Y. ABDELMAGID ◽  
...  
Keyword(s):  
Immune Response ◽  
Bovine Herpesvirus ◽  
Bovine Herpesvirus 1 ◽  
Herpesvirus 1
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