scholarly journals Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains

2015 ◽  
Vol 28 (5) ◽  
pp. 272-281 ◽  
Author(s):  
Natalya V. Krylova ◽  
Tatiana P. Smolina ◽  
Galina N. Leonova
Keyword(s):  
Immune Cells ◽  
Molecular Mechanisms ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Human Immune ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Virus Strains

scholarly journals Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1494
Author(s):  
Ivan K. Baykov ◽  
Pavel Y. Desyukevich ◽  
Ekaterina E. Mikhaylova ◽  
Olga M. Kurchenko ◽  
Nina V. Tikunova
Keyword(s):  
Rational Design ◽  
Fold Increase ◽  
Encephalitis Virus ◽  
Chimeric Antibody ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Glycoprotein E ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3 domain of the glycoprotein E of the Far Eastern subtype of the virus, but a lower affinity for the D3 domains of the Siberian and European subtypes. In this study, a 2.2-fold increase in the affinity of single-chain antibody sc14D5 to D3 proteins of the Siberian and European subtypes of the virus was achieved using rational design and computational modeling. This improvement can be further enhanced in the case of the bivalent binding of the full-length chimeric antibody containing the identified mutation.

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients

2015 ◽  
Vol 6 (1) ◽  
pp. 38-46 ◽  
Author(s):  
Petra Formanová ◽  
Jiří Černý ◽  
Barbora Černá Bolfíková ◽  
James J. Valdés ◽  
Irina Kozlova ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Encephalitis Virus ◽  
Full Genome ◽  
Genome Sequences ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Virus Strains

Tick-borne encephalitides

2011 ◽  
Author(s):  
Patricia A. Nuttall
Keyword(s):  
North America ◽  
Tick Species ◽  
Encephalitis Virus ◽  
Virus Family ◽  
Wild Mammals ◽  
Tick Borne Encephalitis ◽  
Powassan Virus ◽  
Louping Ill ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Tick-borne encephalitides are caused by three different viruses transmitted by ticks and belonging to the Flaviviridae virus family: tick-borne encephalitis virus (Far Eastern, Siberian, and European subtypes), louping ill virus, and Powassan virus (including deer tick virus). These viruses cause encephalitis affecting humans in Eurasia and North America. In nature, they are maintained in transmission cycles involving Ixodes tick species and small or medium-sized wild mammals. The tick-borne flavivirus group is one of the most intensely studied groups of tick-borne pathogens.

Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and far-eastern subtype strains

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4774-4779 ◽  
Author(s):  
Daisuke Hayasaka ◽  
Akiko Goto ◽  
Kentarou Yoshii ◽  
Tetsuya Mizutani ◽  
Hiroaki Kariwa ◽  
...  
Keyword(s):  
Virus Vaccine ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

scholarly journals Comparative analysis of genomes of tick-borne encephalitis virus strains isolated from mosquitoes and ticks

2017 ◽  
Vol 62 (1) ◽  
pp. 30-35 ◽  
Author(s):  
N. M. Pukhovskaya ◽  
O. V. Morozova ◽  
N. B. Belozerova ◽  
S. V. Bakhmetyeva ◽  
N. P. Vysochina ◽  
...  
Keyword(s):  
Vaccine Strain ◽  
Far East ◽  
Encephalitis Virus ◽  
Ixodes Persulcatus ◽  
Aedes Vexans ◽  
Tick Borne Encephalitis ◽  
Tbev Strain ◽  
Natural Foci ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

The tick-borne encephalitis virus (TBEV) strain Lazo MP36 was isolated from the pool of mosquitoes Aedes vexans collected in Lazo region of Khabarovsk territory in August 2014. Phylogenetic analysis of the strain Lazo MP36 complete genome (GenBank accession number KT001073) revealed its correspondence to the TBEV Far Eastern subtype and differences from the following strains: 1) from ticks Ixodes persulcatus P. Schulze, 1930 [vaccine strain 205 (JX498939) and strains Khekhtzir 1230 (KF880805), Chichagovka (KP844724), Birobidzhan 1354 (KF880805) isolated in 2012-2013]; 2) from mosquitoes [strain Malyshevo (KJ744034) isolated in 1978 from Aedes vexans nipponii in Khabarovsk territory; strain Sakhalin 6-11 isolated from the pool of mosquitoes in 2011 (KF826916)]; 3) from human brain [vaccine strain Sofjin (JN229223), Glubinnoe/2004(DQ862460). Kavalerovo (DQ862460), Svetlogorie (DQ862460)]. The fusion peptide necessary for flavivirus entry to cells of the three TBEV strains isolated from mosquitoes (Lazo MP36, Malyshevo and Sakhalin 6-11) has the canonical structure 98-DRGWGNHCGLFGKGSI-113 for the tick-borne flaviviruses. Amino acid transition H104G typical for the mosquito-borne flaviviruses was not found. Structures of 5’- and 3’-untranslated (UTR) regions of the TBEV strains from mosquitoes were 85-98% homologous to the TBEV strains of all subtypes without recombination with mosquito-borne flaviviruses found in the Far East of Russia. Secondary structures of 5’- and 3'-UTR as well as cyclization sequences (CS) of types a and B are highly homologous for all TBEV isolates independently of the biological hosts and vectors. similarity of the genomes of the TBEV isolates from mosquitoes, ticks and patients as well as pathogenicity of the isolates for new-borne laboratory mice and tissue cultures might suggest a possible role of mosquitoes in the TBEV circulation in natural foci as an accidental or additional virus carrier.

Evaluation of vaccine Encepur® Adult for induction of human neutralizing antibodies against recent Far Eastern subtype strains of tick-borne encephalitis virus

Vaccine ◽  
2007 ◽  
Vol 25 (5) ◽  
pp. 895-901 ◽  
Author(s):  
Galina N. Leonova ◽  
Vladimir A. Ternovoi ◽  
Elena V. Pavlenko ◽  
Olga S. Maistrovskaya ◽  
Elena V. Protopopova ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Characteristics of far eastern strains of tick-borne encephalitis virus

2017 ◽  
Vol 162 (8) ◽  
pp. 2211-2218 ◽  
Author(s):  
Galina N. Leonova ◽  
Sergei I. Belikov ◽  
Ilya G. Kondratov
Keyword(s):  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern
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