Pandemic H1N1 Influenza A Virus Induces A Potent Innate Immune Response In Human Chorionic Cells

2014 ◽  
Vol 27 (3) ◽  
pp. 129-137 ◽  
Author(s):  
Sandeep R. P. Kumar ◽  
Moanaro Biswas ◽  
Subbiah Elankumaran
Keyword(s):  
Immune Response ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Innate Immune ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 Influenza

scholarly journals Overweight and obese adult humans have a defective cellular immune response to pandemic H1N1 Influenza a virus

Obesity ◽  
2013 ◽  
Vol 21 (11) ◽  
pp. 2377-2386 ◽  
Author(s):  
Heather A. Paich ◽  
Patricia A. Sheridan ◽  
Jean Handy ◽  
Erik A. Karlsson ◽  
Stacey Schultz-Cherry ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza A Virus ◽  
Cellular Immune Response ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
Obese Adult ◽  
Pandemic H1n1 Influenza ◽  
Adult Humans ◽  
Cellular Immune

scholarly journals A Functional Variation in CD55 Increases the Severity of 2009 Pandemic H1N1 Influenza A Virus Infection

2012 ◽  
Vol 206 (4) ◽  
pp. 495-503 ◽  
Author(s):  
Jie Zhou ◽  
Kelvin Kai-Wang To ◽  
Hui Dong ◽  
Zhong-Shan Cheng ◽  
Candy Choi-Yi Lau ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
Functional Variation ◽  
Pandemic H1n1 Influenza ◽  
Influenza A Virus Infection

scholarly journals Coinfection with Mycobacterium tuberculosis and pandemic H1N1 influenza A virus in a patient with lung cancer

2011 ◽  
Vol 44 (4) ◽  
pp. 316-318 ◽  
Author(s):  
Che-Kim Tan ◽  
Chiang-Lian Kao ◽  
Jin-Yuan Shih ◽  
Li-Na Lee ◽  
Chien-Ching Hung ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mycobacterium Tuberculosis ◽  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 Influenza

Alice in Wonderland Syndrome Caused by the 2009 Pandemic H1N1 Influenza A Virus

2011 ◽  
Vol 30 (8) ◽  
pp. 727-728 ◽  
Author(s):  
Hirohumi Nakaya ◽  
Takehisa Yamamoto ◽  
Mika Takano ◽  
Katsusuke Yamamoto ◽  
Yasuhiro Hujikawa ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Pandemic H1n1 ◽  
Pandemic H1n1 Influenza ◽  
Alice In Wonderland

Bayesian coalescent analysis of pandemic H1N1 influenza A virus circulating in the South American region

2012 ◽  
Vol 170 (1-2) ◽  
pp. 91-101 ◽  
Author(s):  
Natalia Goñi ◽  
Gonzalo Moratorio ◽  
Leticia Coppola ◽  
Viviana Ramas ◽  
Victoria Comas ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
South American ◽  
Pandemic H1n1 ◽  
The South ◽  
Coalescent Analysis ◽  
Pandemic H1n1 Influenza ◽  
South American Region ◽  
American Region

scholarly journals Increased Viral Loads and Exacerbated Innate Host Responses in Aged Macaques Infected with the 2009 Pandemic H1N1 Influenza A Virus

2012 ◽  
Vol 86 (20) ◽  
pp. 11115-11127 ◽  
Author(s):  
L. Josset ◽  
F. Engelmann ◽  
K. Haberthur ◽  
S. Kelly ◽  
B. Park ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
H1n1 Influenza ◽  
Host Responses ◽  
Pandemic H1n1 ◽  
Viral Loads ◽  
Pandemic H1n1 Influenza

scholarly journals The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation

2021 ◽  
Vol 17 (2) ◽  
pp. e1009300
Author(s):  
Yan Zeng ◽  
Shuai Xu ◽  
Yanli Wei ◽  
Xuegang Zhang ◽  
Qian Wang ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza A Virus ◽  
Innate Immune Response ◽  
Influenza A ◽  
Innate Immune ◽  
Negative Regulator ◽  
Poly I:C ◽  
H7n9 Virus ◽  
Autophagic Degradation ◽  
Negative Regulatory Mechanism

Influenza A virus (IAV) has evolved various strategies to counteract the innate immune response using different viral proteins. However, the mechanism is not fully elucidated. In this study, we identified the PB1 protein of H7N9 virus as a new negative regulator of virus- or poly(I:C)-stimulated IFN induction and specifically interacted with and destabilized MAVS. A subsequent study revealed that PB1 promoted E3 ligase RNF5 to catalyze K27-linked polyubiquitination of MAVS at Lys362 and Lys461. Moreover, we found that PB1 preferentially associated with a selective autophagic receptor neighbor of BRCA1 (NBR1) that recognizes ubiquitinated MAVS and delivers it to autophagosomes for degradation. The degradation cascade mediated by PB1 facilitates H7N9 virus infection by blocking the RIG-I-MAVS-mediated innate signaling pathway. Taken together, these data uncover a negative regulatory mechanism involving the PB1-RNF5-MAVS-NBR1 axis and provide insights into an evasion strategy employed by influenza virus that involves selective autophagy and innate signaling pathways.

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