High Frequency of Variant Alleles of the Mannose-Binding Lectin 2 (MBL2)Gene Are Associated with Patients Infected by Hepatitis B Virus

2010 ◽  
Vol 23 (4) ◽  
pp. 449-453 ◽  
Author(s):  
Roberto Magalhães Filho ◽  
Rodrigo F. Carmo ◽  
Coriene Catsman ◽  
Carlos Souza ◽  
André Silva ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
High Frequency ◽  
Mannose Binding Lectin ◽  
Mbl2 Gene ◽  
B Virus ◽  
Mannose Binding ◽  
Variant Alleles ◽  
Binding Lectin

scholarly journals Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

2013 ◽  
Vol 66 (5) ◽  
pp. 391-393 ◽  
Author(s):  
Yuzhong Wu ◽  
Qunyan Zhou ◽  
Huihua Wang ◽  
Ting Tian ◽  
Qiuyuan Zhu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Potential Role ◽  
Mannose Binding Lectin ◽  
Intrauterine Transmission ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Association between Mannose-Binding Lectin Gene Polymorphisms and Hepatitis B Virus Infection: A Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e75371 ◽  
Author(s):  
Hang-di Xu ◽  
Ming-fei Zhao ◽  
Tian-hong Wan ◽  
Guang-zhong Song ◽  
Ji-liang He ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose Binding Lectin Genotypes Influence Recovery from Hepatitis B Virus Infection

2005 ◽  
Vol 79 (14) ◽  
pp. 9192-9196 ◽  
Author(s):  
Chloe L. Thio ◽  
Timothy Mosbruger ◽  
Jacquie Astemborski ◽  
Spencer Greer ◽  
Gregory D. Kirk ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Viral Persistence ◽  
Mannose Binding Lectin ◽  
Central Component ◽  
Nucleotide Polymorphisms ◽  
B Virus ◽  
Mannose Binding ◽  
Exon 1 ◽  
Binding Lectin

ABSTRACT Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. We tested this hypothesis by using a nested case control design with 189 persons with HBV persistence matched to 338 individuals who had naturally recovered from HBV infection. We determined genotypes of two promoter and three exon 1 SNPs in mbl2 and grouped these genotypes according to the amount of functional MBL production. We found that the promoter SNP −221C, which leads to deficient MBL production, was more common in those subjects with viral persistence (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.01 to 1.89; P = 0.04). Those subjects homozygous for the combination of promoter and exon 1 genotypes associated with the highest amount of functional MBL had significantly increased odds of recovery from infection (OR, 0.55; 95% CI, 0.37 to 0.84; P = 0.005). Conversely, those homozygous for the combination of promoter and exon 1 genotypes which produce the lowest amount of functional MBL were more likely to have viral persistence (OR, 1.76; 95% CI, 1.02 to 3.01; P = 0.04). These data are consistent with the hypothesis that functional MBL plays a central role in the pathogenesis of acute hepatitis B.

scholarly journals Association study between mannose-binding lectin haplotypes and X gene mutation of hepatitis B virus from treatment naïve patients

Aging ◽  
2016 ◽  
Vol 8 (11) ◽  
pp. 2862-2870 ◽  
Author(s):  
Chenghao Su ◽  
Yong Lin ◽  
Qianguo Mao ◽  
Daitze Wu ◽  
Lina Zhu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Association Study ◽  
Gene Mutation ◽  
Mannose Binding Lectin ◽  
B Virus ◽  
Mannose Binding ◽  
Treatment Naïve ◽  
X Gene ◽  
Binding Lectin

Role of Levels of Mannose-Binding Lectin in Hepatitis B Virus Infection

2015 ◽  
Vol 3 (1) ◽  
pp. 26-31
Author(s):  
Yeşim Alpay ◽  
◽  
Ergin Ayaşlıoğlu ◽  
Fahri Yakaryılmaz ◽  
Üçler Kısa
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Mannose Binding Lectin ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin

No Association between Mannose-Binding Lectin Alleles and Susceptibility to Chronic Hepatitis B Virus Infection in German Patients

1998 ◽  
Vol 15 (3) ◽  
pp. 130-133 ◽  
Author(s):  
Thomas Höhler ◽  
Markus Wünschel ◽  
Guido Gerken ◽  
Peter M. Schneider ◽  
Karl-H. Meyer zum Büschenfelde ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Infection ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Mannose Binding ◽  
Binding Lectin
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