Humoral Immune Response Against Human Bocavirus VP2 Virus-Like Particles

2008 ◽  
Vol 21 (4) ◽  
pp. 443-450 ◽  
Author(s):  
Juha Lindner ◽  
Lüdya Karalar ◽  
Sandra Zehentmeier ◽  
Annelie Plentz ◽  
Heiko Pfister ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Human Bocavirus ◽  
Virus Like Particles ◽  
Humoral Immune

scholarly journals Production of dengue virus-like particles serotype-3 in silkworm larvae and their ability to elicit a humoral immune response in mice

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Doddy Irawan Setyo Utomo ◽  
Sabar Pambudi ◽  
Fithriyah Sjatha ◽  
Tatsuya Kato ◽  
Enoch Y. Park
Keyword(s):  
Immune Response ◽  
Dengue Virus ◽  
Humoral Immune Response ◽  
Silkworm Larvae ◽  
Virus Like Particles ◽  
Humoral Immune

Vaccination with coxsackievirus B3 virus-like particles elicits humoral immune response and protects mice against myocarditis

Vaccine ◽  
2012 ◽  
Vol 30 (13) ◽  
pp. 2301-2308 ◽  
Author(s):  
L. Zhang ◽  
N.J. Parham ◽  
F. Zhang ◽  
M. Aasa-Chapman ◽  
E.A. Gould ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Coxsackievirus B3 ◽  
Virus Like Particles ◽  
Humoral Immune

scholarly journals Immunogenicity of HIV Virus-Like Particles in Rhesus Macaques by Intranasal Administration

2012 ◽  
Vol 19 (6) ◽  
pp. 970-973 ◽  
Author(s):  
Luigi Buonaguro ◽  
Maria Tagliamonte ◽  
Maria Luisa Visciano ◽  
Hanne Andersen ◽  
Mark Lewis ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Intranasal Administration ◽  
Rhesus Macaques ◽  
Virus Like Particles ◽  
Humoral Immune ◽  
Hiv Dna ◽  
Hiv Virus ◽  
Female Rhesus ◽  
Female Rhesus Macaques

ABSTRACTFemale rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.

Role of Yersinia pseudotuberculosis outer proteins (Yops) in murine humoral immune response

2009 ◽  
Vol 54 (3) ◽  
pp. 239-245 ◽  
Author(s):  
J. M. L. Maia ◽  
L. G. S. Monnazzi ◽  
B. M. M. Medeiros
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Yersinia Pseudotuberculosis ◽  
Humoral Immune

scholarly journals Diagnostic and analytical performance evaluation of ten commercial assays for detecting SARS-CoV-2 humoral immune response

2021 ◽  
pp. 113043
Author(s):  
Marnix Mylemans ◽  
Eveline Van Honacker ◽  
Louis Nevejan ◽  
Stefanie van den Bremt ◽  
Laura Hofman ◽  
...  
Keyword(s):  
Immune Response ◽  
Performance Evaluation ◽  
Humoral Immune Response ◽  
Analytical Performance ◽  
Humoral Immune

scholarly journals SARS-CoV-2 RNA and antibodies in tear fluid

2021 ◽  
Vol 6 (1) ◽  
pp. e000733
Author(s):  
Astrid Muyldermans ◽  
Maria Bjerke ◽  
Thomas Demuyser ◽  
Deborah De Geyter ◽  
Ingrid Wybo ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Spike Protein ◽  
Tear Fluid ◽  
Local Response ◽  
Schirmer Test ◽  
Humoral Immune ◽  
Non Invasive ◽  
Reverse Transcription Pcr ◽  
Ocular Symptoms

Background/aimsSARS-CoV-2 is highly contagious. More evidence concerning extrapulmonary transmission routes such as the eyes is urgently needed. Although the humoral immune response is important in the viral containment, the local response in tears has not yet been studied. The aim of our study was twofold: to assess the prevalence of both SARS-CoV-2 RNA and antibodies in tear fluid.MethodsIn a first series, nasopharyngeal sampling and tear sampling by Schirmer test strips were performed in 26 acutely ill patients with COVID-19 to assess the presence of SARS-CoV-2 RNA by reverse transcription PCR. In a second series, IgG and IgA responses to SARS-CoV-2 spike protein in serum and tear fluid of convalescent individuals (n=22) were compared with control individuals (n=15) by ELISA.ResultsSARS-CoV-2 RNA was detected in tears of 7/26 (26.9%) patients with COVID-19. None of them had ocular symptoms. Convalescent individuals displayed a significant higher ratio of IgG (p<0.0001) and IgA (p=0.0068) in tears compared with control individuals. A sensitivity of 77.3% and specificity of 93.3% was observed for IgG, and 59.1% and 100% for IgA.ConclusionsOur results demonstrate the presence of SARS-CoV-2 RNA and a local IgG and IgA immune response in tear fluid. These data confirm the possibility of SARS-CoV-2 transmission through tear fluid and the importance of the eye as a first defence against SARS-CoV-2, indicating the potential of tears as a non-invasive surrogate for serum in monitoring the host immune response.

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