Cellular and Humoral Immunogenicity of Hamster Polyomavirus-Derived Virus-Like Particles Harboring a Mucin 1 Cytotoxic T-Cell Epitope

2008 ◽  
Vol 21 (1) ◽  
pp. 12-26 ◽  
Author(s):  
David C. Dorn ◽  
Robert Lawatscheck ◽  
Aurelija Zvirbliene ◽  
Egle Aleksaite ◽  
Gabriele Pecher ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
Mucin 1 ◽  
Virus Like Particles ◽  
Hamster Polyomavirus

scholarly journals Identification of an MSI-H Tumor-Specific Cytotoxic T Cell Epitope Generated by the (−1) Frame ofU79260(FTO)

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Michael Linnebacher ◽  
Anne Wienck ◽  
Inga Boeck ◽  
Ernst Klar
Keyword(s):  
T Cell ◽  
Dna Sequences ◽  
Immune Surveillance ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
Repair System ◽  
T Cell Epitope ◽  
Reading Frame ◽  
Dna Mismatch ◽  
Dna Mismatch Repair System

Microsatellite instability (MSI-H) induced by defects of the DNA mismatch repair system results in insertion or deletion of single nucleotides at short repetitive DNA sequences. About 15% of sporadic and approximately 90% of hereditary nonpolyposis colorectal cancers display MSI-H. When affecting coding regions, MSI-H results in frameshift mutations and expression of corresponding frameshift peptides (FSPs). Functional tumor promoting relevance has been demonstrated for a growing number of genes frequently hit by MSI-H. Contrary, immune reactions against FSPs are involved in the immune surveillance of MSI-H cancers. Here, we provide conclusive data that the (−1) frame ofU79260(FTO)encodes an HLA-A0201-restricted cytotoxic T cell epitope (FSP11; TLSPGWSAV). T cells specific for FSP11 efficiently recognized HLA-A0201(pos)tumor cells harboring the mutated reading frame. Considering the exceptionally high mutation rate ofU79260(FTO)in MSI-H colorectal carcinoma (81.8%), this recommends that FSP11 be a component of future vaccines.

scholarly journals Identification of the immunodominant cytotoxic T-cell epitope of human -1 antitrypsin

Gene Therapy ◽  
2009 ◽  
Vol 16 (11) ◽  
pp. 1380-1382 ◽  
Author(s):  
E Breous ◽  
S Somanathan ◽  
J M Wilson
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope

scholarly journals An immunodominant cytotoxic T cell epitope on the VP7 rotavirus protein overlaps the H2 signal peptide

1993 ◽  
Vol 74 (12) ◽  
pp. 2579-2586 ◽  
Author(s):  
M. A. Franco ◽  
I. Prieto ◽  
M. Labbe ◽  
D. Poncet ◽  
F. Borras-Cuesta ◽  
...  
Keyword(s):  
T Cell ◽  
Signal Peptide ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope

scholarly journals Influence of flanking sequences on presentation efficiency of a CD8+ cytotoxic T-cell epitope delivered by parvovirus-like particles

2004 ◽  
Vol 85 (3) ◽  
pp. 563-572 ◽  
Author(s):  
P. Rueda ◽  
G. Morón ◽  
J. Sarraseca ◽  
C. Leclerc ◽  
J. I. Casal
Keyword(s):  
T Cell ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope ◽  
Flanking Sequences

scholarly journals Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C virus NS3 region.

1996 ◽  
Vol 70 (1) ◽  
pp. 232-240 ◽  
Author(s):  
K Kurokohchi ◽  
T Akatsuka ◽  
C D Pendleton ◽  
A Takamizawa ◽  
M Nishioka ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
T Cell ◽  
Recombinant Protein ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
T Cell Epitope
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