Long-Lasting Poliovirus-Neutralizing Antibodies among Argentinean Population Immunized with Four Or Five Oral Polio Vaccine Doses 1 Month to 19 Years Previously

2007 ◽  
Vol 20 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Silvia V. Nates ◽  
Laura C. Martinez ◽  
Patricia A. Barril ◽  
Leonardo J. Ferreyra ◽  
Miguel O. Giordano ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Oral Polio Vaccine ◽  
Polio Vaccine

scholarly journals Advax-CpG Adjuvant Provides Antigen Dose-Sparing and Enhanced Immunogenicity for Inactivated Poliomyelitis Virus Vaccines

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 500
Author(s):  
Yoshikazu Honda-Okubo ◽  
Jeremy Baldwin ◽  
Nikolai Petrovsky
Keyword(s):  
Neutralizing Antibodies ◽  
Serum Antibody ◽  
Oral Polio Vaccine ◽  
Antigen Dose ◽  
Polio Vaccine ◽  
Antibody Titers ◽  
Dose Sparing ◽  
Sparing Effect ◽  
Eradicate Polio

Global immunization campaigns have resulted in a major decline in the global incidence of polio cases, with wild-type poliovirus remaining endemic in only two countries. Live oral polio vaccine (OPV) played a role in the reduction in polio case numbers; however, the risk of OPV developing into circulating vaccine-derived poliovirus makes it unsuitable for eradication programs. Trivalent inactivated polio virus (TIPV) vaccines which contain formalin-inactivated antigens produced from virulent types 1, 2 and 3 reference polio strains grown in Vero monkey kidney cells have been advocated as a replacement for OPV; however, TIPVs have weak immunogenicity and multiple boosts are required before peak neutralizing titers are reached. This study examined whether the incorporation of the novel polysaccharide adjuvant, Advax-CpG, could boost the immunogenicity of two TIPV vaccines, (i) a commercially available polio vaccine (IPOL®, Sanofi Pasteur) and (ii) a new TIPV formulation developed by Statens Serum Institut (SSI). Mice were immunized intramuscularly based on recommended vaccine dosage schedules and serum antibody titers were followed for 12 months post-immunization. Advax-CpG significantly enhanced the long-term immunogenicity of both TIPV vaccines and had at least a 10-fold antigen dose-sparing effect. An exception was the poor ability of the SSI TIPV to induce serotype type 1 neutralizing antibodies. Immunization with monovalent IPVs suggested that the low type 1 response to TIPV may be due to antigen competition when the type 1 antigen was co-formulated with the type 2 and 3 antigens. This study provides valuable insights into the complexity of the formulation of multivalent polio vaccines and supports the further development of adjuvanted antigen-sparing TIPV vaccines in the fight to eradicate polio.

scholarly journals Immunogenicity of Oral Polio Vaccine and Salk Inactive Polio Vaccine Against Xinjiang Imported Type 1 Wild Poliovirus

2019 ◽  
Vol 70 (9) ◽  
pp. 1980-1984 ◽  
Author(s):  
Dongmei Yan ◽  
Dongyan Wang ◽  
Shuangli Zhu ◽  
Yong Zhang ◽  
Xiaolei Li ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Oral Polio Vaccine ◽  
Neutralizing Antibody ◽  
Genomic Sequencing ◽  
Outbreak Response ◽  
Local Immunity ◽  
Wild Poliovirus ◽  
Polio Vaccine ◽  
Antibody Titers

Abstract Background An outbreak of an imported Type 1 wild poliovirus from Pakistan occurred in the Xinjiang Uygur Autonomous Region of China in 2011, although the local immunity status of the oral polio vaccine (OPV) was relatively satisfied. Methods Neutralizing antibody titers against the Xinjiang strain and Sabin 1 strain were measured in 237 sera from 3 groups of fully OPV-vaccinated persons and 1 group of infants fully vaccinated with the inactive polio vaccine (IPV). Additionally, 17 sera collected from 1 Xinjiang poliomyelitis case and his 16 contacts were also tested. Genomic sequencing was conducted the Xinjiang strain. Results The antibody titers against the Xinjiang strain in each of 237 sera were significantly lower than those against the Sabin 1 strain. Notably, 40.0% of children in Group 1 were seronegative against the Xinjiang strain, which indicated that they might play an important role in wild poliovirus transmission, although their antibody titers against the Sabin 1 strain varied between 1:8 and 1:512. Meanwhile, serological results of the Xinjiang poliomyelitis case and his contacts also provided evidence that a proportion of OPV-vaccinated children had indeed been involved in the transmission chain of the Xinjiang outbreak. Genomic sequencing indicated that the Xinjiang strain was greatly distinguishable from the Sabin 1 strain in neutralizing antigenic sites. Conclusion The lack of neutralizing antibodies against the Xinjiang strain in persons vaccinated by OPV may be associated with the transmission of Type 1 wild poliovirus in Xinjiang. Using Salk IPV along with OPV might be considered in a wild poliovirus outbreak response, especially in the countries which continued to have persistent wild poliovirus circulation.

Towards Polio Eradication in Nigeria: Identifying at Risk Population for Low Oral Polio Vaccine (OPV) Uptake

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 389A-389A
Author(s):  
Oluyemisi O. Falope ◽  
Korede K. Adegoke ◽  
Chukwudi O. Ejiofor ◽  
Nnadozie C. Emechebe ◽  
Taiwo O Talabi ◽  
...  
Keyword(s):  
At Risk ◽  
Oral Polio Vaccine ◽  
Polio Eradication ◽  
Risk Population ◽  
Polio Vaccine

scholarly journals The case for replacing live oral polio vaccine with inactivated vaccine in the Americas

The Lancet ◽  
2020 ◽  
Vol 395 (10230) ◽  
pp. 1163-1166
Author(s):  
Jorge A Alfaro-Murillo ◽  
Marí L Ávila-Agüero ◽  
Meagan C Fitzpatrick ◽  
Caroline J Crystal ◽  
Luiza-Helena Falleiros-Arlant ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Inactivated Vaccine ◽  
Polio Vaccine

scholarly journals Inferring Numbers of Wild Poliovirus Excretors Using Quantitative Environmental Surveillance

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 870
Author(s):  
Yuri Perepliotchikov ◽  
Tomer Ziv-Baran ◽  
Musa Hindiyeh ◽  
Yossi Manor ◽  
Danit Sofer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Turnaround Time ◽  
Quantitative Detection ◽  
Environmental Surveillance ◽  
Wild Poliovirus ◽  
Polio Vaccine ◽  
Kinetic Information ◽  
Using Data ◽  
Number Of Individuals

Response to and monitoring of viral outbreaks can be efficiently focused when rapid, quantitative, kinetic information provides the location and the number of infected individuals. Environmental surveillance traditionally provides information on location of populations with contagious, infected individuals since infectious poliovirus is excreted whether infections are asymptomatic or symptomatic. Here, we describe development of rapid (1 week turnaround time, TAT), quantitative RT-PCR of poliovirus RNA extracted directly from concentrated environmental surveillance samples to infer the number of infected individuals excreting poliovirus. The quantitation method was validated using data from vaccination with bivalent oral polio vaccine (bOPV). The method was then applied to infer the weekly number of excreters in a large, sustained, asymptomatic outbreak of wild type 1 poliovirus in Israel (2013) in a population where >90% of the individuals received three doses of inactivated polio vaccine (IPV). Evidence-based intervention strategies were based on the short TAT for direct quantitative detection. Furthermore, a TAT shorter than the duration of poliovirus excretion allowed resampling of infected individuals. Finally, the method documented absence of infections after successful intervention of the asymptomatic outbreak. The methodologies described here can be applied to outbreaks of other excreted viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where there are (1) significant numbers of asymptomatic infections; (2) long incubation times during which infectious virus is excreted; and (3) limited resources, facilities, and manpower that restrict the number of individuals who can be tested and re-tested.

scholarly journals Oral Polio Vaccine Influences the Immune Response to BCG Vaccination. A Natural Experiment

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10328 ◽  
Author(s):  
Erliyani Sartono ◽  
Ida M. Lisse ◽  
Elisabeth M. Terveer ◽  
Paula J. M. van de Sande ◽  
Hilton Whittle ◽  
...  
Keyword(s):  
Immune Response ◽  
Natural Experiment ◽  
Oral Polio Vaccine ◽  
Bcg Vaccination ◽  
Polio Vaccine

scholarly journals Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice

2003 ◽  
Vol 77 (11) ◽  
pp. 6541-6545 ◽  
Author(s):  
Hein J. Boot ◽  
Daniella T. J. Kasteel ◽  
Anne-Marie Buisman ◽  
Tjeerd G. Kimman
Keyword(s):  
Transgenic Mice ◽  
Oral Polio Vaccine ◽  
Fecal Excretion ◽  
Wild Type ◽  
Genetic Determinants ◽  
Poliovirus Type ◽  
Oral Transmission ◽  
Polio Vaccine ◽  
Poliovirus Receptor

ABSTRACT The emergence of circulating vaccine-derived poliovirus (cVDPV) strains in suboptimally vaccinated populations is a serious threat to the global poliovirus eradication. The genetic determinants for the transmissibility phenotype of polioviruses, and in particularly of cVDPV strains, are currently unknown. Here we describe the fecal excretion of wild-type poliovirus, oral polio vaccine, and cVDPV (Hispaniola) strains after intraperitoneal injection in poliovirus receptor-transgenic mice. Both the pattern and the level of fecal excretion of the cVDPV strains resemble those of wild-type poliovirus type 1. In contrast, very little poliovirus was present in the feces after oral polio vaccine administration. This mouse model will be helpful in elucidating the genetic determinants for the high fecal-oral transmission phenotype of cVDPV strains.

scholarly journals Evaluating cessation of the type 2 oral polio vaccine by modeling pre- and post-cessation detection rates

Vaccine ◽  
2017 ◽  
Vol 35 (42) ◽  
pp. 5674-5681 ◽  
Author(s):  
Steve J. Kroiss ◽  
Michael Famulare ◽  
Hil Lyons ◽  
Kevin A. McCarthy ◽  
Laina D. Mercer ◽  
...  
Keyword(s):  
Oral Polio Vaccine ◽  
Detection Rates ◽  
Polio Vaccine

scholarly journals Immunogenicity of Inactivated Polio Vaccine with Concurrent Antiviral V-073 Administration in Mice

2011 ◽  
Vol 18 (8) ◽  
pp. 1387-1390 ◽  
Author(s):  
Diana Kouiavskaia ◽  
Marc S. Collett ◽  
Eugenia M. Dragunsky ◽  
Andrey Sarafanov ◽  
Konstantin M. Chumakov
Keyword(s):  
Neutralizing Antibodies ◽  
Inactivated Polio Vaccine ◽  
Polio Vaccine ◽  
Detrimental Impact

ABSTRACTImmunization of mice with inactivated polio vaccine (IPV) with concurrent dosing of poliovirus antiviral V-073 showed no detrimental impact on the elicitation of serum-neutralizing antibodies. A strategy involving coadministration of antiviral V-073 and IPV can be considered for the management of poliovirus incidents.

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