Recombinant Adenovirus Vector Vaccine Induces Stronger Cytotoxic T-Cell Responses Than Recombinant Vaccinia Virus Vector, Plasmid DNA, or a Combination of These

2005 ◽  
Vol 18 (4) ◽  
pp. 657-667 ◽  
Author(s):  
Ken Maeda ◽  
Kim West ◽  
Daisuke Hayasaka ◽  
Francis A. Ennis ◽  
Masanori Terajima
Keyword(s):  
Recombinant Adenovirus ◽  
Adenovirus Vector ◽  
Recombinant Vaccinia Virus ◽  
Cytotoxic T Cell ◽  
Vector Plasmid ◽  
Vector Vaccine ◽  
Cell Responses ◽  
Recombinant Adenovirus Vector ◽  
Vaccinia Virus Vector ◽  
Cytotoxic T Cell Responses

scholarly journals HIV mRNA Vaccines—Progress and Future Paths

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 134
Author(s):  
Zekun Mu ◽  
Barton F. Haynes ◽  
Derek W. Cain
Keyword(s):  
T Cell ◽  
Neutralizing Antibodies ◽  
Vaccination Strategy ◽  
T Cell Responses ◽  
Neutralizing Antibody ◽  
Cytotoxic T Cell ◽  
Therapeutic Vaccines ◽  
Cell Responses ◽  
Broadly Neutralizing Antibody ◽  
Cytotoxic T Cell Responses

The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly, an mRNA-based vaccine relies on the host’s cells to manufacture protein immunogens which, in turn, are targets for antibody and cytotoxic T cell responses. mRNA-based vaccines have been the subject of research for over three decades as a platform to protect against or treat a variety of cancers, amyloidosis and infectious diseases. In this review, we discuss mRNA-based approaches for the generation of prophylactic and therapeutic vaccines to HIV. We examine the special immunological hurdles for a vaccine to elicit broadly neutralizing antibodies and effective T cell responses to HIV. Lastly, we outline an mRNA-based HIV vaccination strategy based on the immunobiology of broadly neutralizing antibody development.

Melanocyte-specific, cytotoxic T cell responses in vitiligo: the effective variant of melanoma immunity?

2005 ◽  
Vol 18 (4) ◽  
pp. 234-242 ◽  
Author(s):  
Silvia Garbelli ◽  
Stefania Mantovani ◽  
Belinda Palermo ◽  
Claudia Giachino
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cytotoxic T Cell ◽  
Cell Responses ◽  
Cytotoxic T Cell Responses

Cytotoxic T Cell Responses against Mesothelioma by Apoptotic Cell-pulsed Dendritic Cells

2004 ◽  
Vol 169 (12) ◽  
pp. 1322-1330 ◽  
Author(s):  
Frédéric Ebstein ◽  
Carole Sapede ◽  
Pierre-Joseph Royer ◽  
Marie Marcq ◽  
Catherine Ligeza-Poisson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Apoptotic Cell ◽  
T Cell Responses ◽  
Cytotoxic T Cell ◽  
Cell Responses ◽  
Cytotoxic T Cell Responses

Development of a recombinant adenovirus vector production system free of replication-competent adenovirus by utilizing a packaging size limit of the viral genome

2011 ◽  
Vol 158 (1-2) ◽  
pp. 154-160 ◽  
Author(s):  
Takayuki Suzuki ◽  
Tomomi Sasaki ◽  
Koyori Yano ◽  
Fuminori Sakurai ◽  
Kenji Kawabata ◽  
...  
Keyword(s):  
Production System ◽  
Viral Genome ◽  
Recombinant Adenovirus ◽  
Adenovirus Vector ◽  
Size Limit ◽  
Recombinant Adenovirus Vector

A simplified cloning strategy for the generation of an endothelial cell selective recombinant adenovirus vector

2006 ◽  
Vol 135 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Chitladda Mahanivong ◽  
Jörg A. Krüger ◽  
Dafang Bian ◽  
Ralph A. Reisfeld ◽  
Shuang Huang
Keyword(s):  
Endothelial Cell ◽  
Recombinant Adenovirus ◽  
Adenovirus Vector ◽  
Cloning Strategy ◽  
Recombinant Adenovirus Vector
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