Epitope Mapping of Rat Neutralizing Monoclonal Antibody Against Human Immunodeficiency Virus Type-1 by a Phage Peptide Library: Comparison with ELISA Using Synthetic Peptides

1999 ◽  
Vol 12 (1) ◽  
pp. 57-66
Author(s):  
KOUJI ICHIYAMA ◽  
DAI ISHIKAWA ◽  
YUETSU TANAKA ◽  
TAKAYUKI KASHIWA ◽  
YOSHIO KOYANAGI ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Synthetic Peptides ◽  
Epitope Mapping ◽  
Peptide Library ◽  
Immunodeficiency Virus ◽  
Neutralizing Monoclonal Antibody ◽  
Phage Peptide Library

scholarly journals Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes

2004 ◽  
Vol 78 (5) ◽  
pp. 2627-2631 ◽  
Author(s):  
Eve de Rosny ◽  
Russell Vassell ◽  
Shibo Jiang ◽  
Renate Kunert ◽  
Carol D. Weiss
Keyword(s):  
Monoclonal Antibody ◽  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Conformational Changes ◽  
Virus Entry ◽  
Immunodeficiency Virus ◽  
Late Step ◽  
Neutralizing Monoclonal Antibody

ABSTRACT We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a late step in virus entry. We also demonstrate conformational changes in the C heptad of gp41.

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