Presence of HLA-C-Restricted Cytotoxic T-Lymphocyte Responses in Long-Term Nonprogressors Infected with Human Immunodeficiency Virus

1998 ◽  
Vol 11 (3) ◽  
pp. 119-129 ◽  
Author(s):  
PRAMOD N. NEHETE ◽  
DOROTHY E. LEWIS ◽  
DEREK NG. TANG ◽  
MARILYN S. POLLACK ◽  
K. JAGANNADHA SASTRY
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Immunodeficiency Virus ◽  
Lymphocyte Responses

scholarly journals Persistent Antibody Responses but Declining Cytotoxic T-Lymphocyte Responses to Multiple Human Immunodeficiency Virus Type 1 Antigens in a Long-Term Nonprogressing Individual with a Defective p17 Proviral Sequence and No Detectable Viral RNA Expression

1998 ◽  
Vol 72 (4) ◽  
pp. 3472-3474 ◽  
Author(s):  
James M. Binley ◽  
Xia Jin ◽  
Yaoxing Huang ◽  
Linqi Zhang ◽  
Yunzhen Cao ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Antibody Responses ◽  
The Past ◽  
Immunodeficiency Virus ◽  
Lymphocyte Responses ◽  
Hiv 1

ABSTRACT Long-term nonprogressor AD-18 has been infected with human immunodeficiency virus type 1 (HIV-1) for at least 16 years. During the past 5 years, he has had undetectable levels of plasma viremia, and HIV-1 cannot be isolated from him. Sequencing of proviral DNA indicates that the only HIV-1 sequences that can be identified in AD-18 have gross defects in the p17-encoding regions of the gag gene (Y. Huang, L. Zhang, and D. D. Ho, Virology 240:36–49, 1998). However, AD-18 has strong, sustained antibody responses to several HIV-1 antigens, including p17. Cytotoxic T-lymphocyte responses to Env and Gag antigens have gradually diminished over the past 4 years, at a time when the titers of antibodies to the same proteins have remained stable. We discuss what these observations might mean for the generation and maintenance of immunological memory.

scholarly journals Cytotoxic T Lymphocyte Responses to Human Immunodeficiency Virus: Control and Escape

Stem Cells ◽  
2000 ◽  
Vol 18 (4) ◽  
pp. 230-244 ◽  
Author(s):  
Andrew K. Sewell ◽  
David A. Price ◽  
Annette Oxenius ◽  
Anthony D. Kelleher ◽  
Rodney E. Phillips
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Virus Control ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Control ◽  
Lymphocyte Responses

Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses

1997 ◽  
Vol 159 (1) ◽  
pp. 17-29 ◽  
Author(s):  
Philip Goulder ◽  
David Price ◽  
Martin Nowak ◽  
Sarah Rowland-Jones ◽  
Rodney Phillips ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Immunodeficiency Virus ◽  
Lymphocyte Responses
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