Changes in the Cytotoxic T-Cell Repertoire of HIV-1-Infected Individuals: Relationship to Disease Progression

1993 ◽  
Vol 6 (1) ◽  
pp. 85-95 ◽  
Author(s):  
MICHAEL D. GRANT ◽  
FIONA M. SMAILL ◽  
KAREN LAURIE ◽  
KENNETH L. ROSENTHAL
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cytotoxic T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hiv 1

scholarly journals Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors

2014 ◽  
Vol 211 (7) ◽  
pp. 1273-1280 ◽  
Author(s):  
Suzanne L. Campion ◽  
Tess M. Brodie ◽  
William Fischer ◽  
Bette T. Korber ◽  
Astrea Rossetti ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Peptide Mapping ◽  
Human Microbiome ◽  
Effector Memory ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Memory Cd4 T Cells ◽  
Hiv 1

The preexisting HIV-1–specific T cell repertoire must influence both the immunodominance of T cells after infection and immunogenicity of vaccines. We directly compared two methods for measuring the preexisting CD4+ T cell repertoire in healthy HIV-1–negative volunteers, the HLA-peptide tetramer enrichment and T cell library technique, and show high concordance (r = 0.989). Using the library technique, we examined whether naive, central memory, and/or effector memory CD4+ T cells specific for overlapping peptides spanning the entire HIV-1 proteome were detectable in 10 HLA diverse, HIV-1–unexposed, seronegative donors. HIV-1–specific cells were detected in all donors at a mean of 55 cells/million naive cells and 38.9 and 34.1 cells/million in central and effector memory subsets. Remarkably, peptide mapping showed most epitopes recognized by naive (88%) and memory (56%) CD4+ T cells had been previously reported in natural HIV-1 infection. Furthermore, 83% of epitopes identified in preexisting memory subsets shared epitope length matches (8–12 amino acids) with human microbiome proteins, suggestive of a possible cross-reactive mechanism. These results underline the power of a proteome-wide analysis of peptide recognition by human T cells for the identification of dominant antigens and provide a baseline for optimizing HIV-1–specific helper cell responses by vaccination.

Monozygotic Twins Display Differences in Their Allospecific Cytotoxic T‐Cell Repertoire

1996 ◽  
Vol 44 (6) ◽  
pp. 638-642 ◽  
Author(s):  
A. V. ReisÆter ◽  
J. E. Brinchmann ◽  
K. E. A. Lundin ◽  
E. Thorsby
Keyword(s):  
T Cell ◽  
Monozygotic Twins ◽  
Cytotoxic T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire

3.22 Diversity of T-Cell Repertoire Predicts Disease Progression in Chronic Lymphocytic Leukaemia

2011 ◽  
Vol 11 ◽  
pp. S212
Author(s):  
C. Holler ◽  
N. Zaborsky ◽  
J. Pinon-Hofbauer ◽  
T. Kocher ◽  
D. Trapin ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukaemia ◽  
Disease Progression ◽  
Lymphocytic Leukaemia ◽  
T Cell Repertoire ◽  
Cell Repertoire

Differences and similarities in the A2.1-restricted cytotoxic T cell repertoire in humans and human leukocyte antigen-transgenic mice

1996 ◽  
Vol 26 (1) ◽  
pp. 97-101 ◽  
Author(s):  
Peggy A. Wentworth ◽  
Antonella Vitiello ◽  
John Sidney ◽  
Elissa Keogh ◽  
Robert W. Chesnut ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Cytotoxic T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Leukocyte Antigen

scholarly journals Availability of a Diversely Avid CD8+T Cell Repertoire Specific for the Subdominant HLA-A2-Restricted HIV-1 Gag p2419–27Epitope

2007 ◽  
Vol 178 (12) ◽  
pp. 7756-7766 ◽  
Author(s):  
Keri L. Schaubert ◽  
David A. Price ◽  
Nicole Frahm ◽  
Jinzhu Li ◽  
Hwee L. Ng ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hiv 1

The influence of lymphocyte counts and disease progression on circulating and inducible anti-HIV-1 cytotoxic T-cell activity in HIV-1-infected subjects

AIDS ◽  
1992 ◽  
Vol 6 (10) ◽  
pp. 1085-1094 ◽  
Author(s):  
Michael D. Grant ◽  
Fiona M. Smaill ◽  
Dharam P. Singal ◽  
Kenneth L. Rosenthal
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Cell Activity ◽  
Cytotoxic T Cell ◽  
Anti Hiv ◽  
Hiv 1

scholarly journals Broadening of the T-Cell Repertoire to HIV-1 Gag p24 by Vaccination of HLA-A2/DR Transgenic Mice with Overlapping Peptides in the CAF05 Adjuvant

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e63575 ◽  
Author(s):  
Karen S. Korsholm ◽  
Ingrid Karlsson ◽  
Sheila T. Tang ◽  
Lea Brandt ◽  
Else Marie Agger ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
T Cell Repertoire ◽  
Cell Repertoire ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document