Apparent Requirement for CD4+T Cells in Primary Anti-Herpes Simplex Virus Cytotoxic T-Lymphocyte Induction Can Be Overcome by Optimal Antigen Presentation

1991 ◽  
Vol 4 (3) ◽  
pp. 177-186 ◽  
Author(s):  
CARMEN M. MERCADAL ◽  
STEPHEN MARTIN ◽  
BARRY T. ROUSE
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Antigen Presentation ◽  
T Lymphocyte ◽  
Cd4 T Cells ◽  
Cytotoxic T Lymphocyte ◽  
Simplex Virus

scholarly journals Identification and Characterization of Herpes Simplex Virus‐Specific CD4+T Cells in Corneas of Herpetic Stromal Keratitis Patients

1998 ◽  
Vol 177 (2) ◽  
pp. 484-488 ◽  
Author(s):  
Georges M. G. M. Verjans ◽  
Lies Remeijer ◽  
Robert S. van Binnendijk ◽  
José G. C. Cornelissen ◽  
Hennie J. Völker‐Dieben ◽  
...  
Keyword(s):  
T Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cd4 T Cells ◽  
Herpetic Stromal Keratitis ◽  
Stromal Keratitis ◽  
Simplex Virus ◽  
Identification And Characterization

scholarly journals Innate Immune Responses to Herpes Simplex Virus Type 2 Influence Skin Homing Molecule Expression by Memory CD4+ Lymphocytes

2006 ◽  
Vol 80 (6) ◽  
pp. 2863-2872 ◽  
Author(s):  
David M. Koelle ◽  
Jay Huang ◽  
Michael T. Hensel ◽  
Christopher L. McClurkan
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cd4 T Cells ◽  
Receptor Expression ◽  
Homing Receptor ◽  
Skin Homing ◽  
Simplex Virus

ABSTRACT Herpes simplex virus (HSV) infections of humans are characterized by intermittent, lytic replication in epithelia. Circulating HSV-specific CD4 T cells express lower levels of preformed cutaneous lymphocyte-associated antigen (CLA), a skin-homing receptor, than do circulating HSV-specific CD8 T cells but, paradoxically, move into infected skin earlier than CD8 cells. Memory CD4 T cells develop strong and selective expression of CLA and E-selectin ligand while responding to HSV antigen in vitro. We now show that interleukin-12, type I interferon, and transforming growth factor beta are each involved in CLA expression by memory HSV type 2 (HSV-2)-specific CD4 T cells in peripheral blood mononuclear cells (PBMC). A reduction of the number of monocytes and dendritic cells from PBMC reduces CLA expression by HSV-2-responsive CD4 lymphoblasts, while their reintroduction restores this phenotype, identifying these cells as possible sources of CLA-promoting cytokines. Plasmacytoid dendritic cells are particularly potent inducers of CLA on HSV-reactive CD4 T cells. These observations are consistent with cooperation between innate and acquired immunity to promote a pattern of homing receptor expression that is physiologically appropriate for trafficking to infected tissues.

Human Cytotoxic T Lymphocyte Responses to Cytomegalovirus and Herpes Simplex Virus

1988 ◽  
Vol 532 (1 Cytotoxic T C) ◽  
pp. 451-452 ◽  
Author(s):  
CHARLES R. RINALDO ◽  
DAVID J. TORPEY ◽  
MARK D. LINDSLEY ◽  
QUAN CAI
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Simplex Virus ◽  
Lymphocyte Responses

Human CD8+ Cytotoxic T Lymphocyte Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

2007 ◽  
Vol 123 ◽  
pp. S32
Author(s):  
Aziz Alami Chentoufi ◽  
Xiuli Zhang ◽  
Kasper Lamberth ◽  
Xiaoming Zhu ◽  
Gargi Dasgupta ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
T Lymphocyte ◽  
Herpes Simplex Virus Type ◽  
Cytotoxic T Lymphocyte ◽  
Glycoprotein D ◽  
Simplex Virus

scholarly journals HLA-A*0201-Restricted CD8+Cytotoxic T Lymphocyte Epitopes Identified from Herpes Simplex Virus Glycoprotein D

2007 ◽  
Vol 180 (1) ◽  
pp. 426-437 ◽  
Author(s):  
Aziz Alami Chentoufi ◽  
Xiuli Zhang ◽  
Kasper Lamberth ◽  
Gargi Dasgupta ◽  
Ilham Bettahi ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Glycoprotein D ◽  
Virus Glycoprotein ◽  
Herpes Simplex Virus Glycoprotein ◽  
Simplex Virus
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