scholarly journals Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015–2017, Southern Italy

2018 ◽  
Vol 18 (6) ◽  
pp. 331-334 ◽  
Author(s):  
Daniela Loconsole ◽  
Angela Metallo ◽  
Anna Lisa De Robertis ◽  
Anna Morea ◽  
Michele Quarto ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Dengue Virus ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Southern Italy ◽  
West Nile ◽  
Virus West Nile ◽  
And Migration

Simultaneous detection of Dengue virus, Chikungunya virus, Zika virus, Yellow fever virus and West Nile virus

2019 ◽  
Vol 268 ◽  
pp. 53-55 ◽  
Author(s):  
José A. Boga ◽  
Marta E. Alvarez-Arguelles ◽  
Susana Rojo-Alba ◽  
Mercedes Rodríguez ◽  
María de Oña ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Dengue Virus ◽  
Yellow Fever ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Yellow Fever Virus ◽  
Simultaneous Detection ◽  
Fever Virus ◽  
West Nile ◽  
Virus Zika

scholarly journals Virus Zika (ZIKV): Struktur, Patogenesis, Diagnosis Laboratorium, dan Pencegahan

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Luh Ade Wilan Krisna
Keyword(s):  
West Nile Virus ◽  
Dengue Virus ◽  
Japanese Encephalitis ◽  
Zika Virus ◽  
Guillain Barre Syndrome ◽  
West Nile ◽  
Guillain Barré Syndrome ◽  
Virus West Nile ◽  
Virus Zika ◽  
Guillain Barré

Virus Zika (ZIKV) adalah flavivirus yang berhubungan dengan dengue, virus demam kuning, virus Japanese encephalitis dan virus west nile. Virus tersebut menyebabkan infeksi melalui gigitan nyamuk yang dikenal sebagai demam zika atau penyakit zika. Virus zika baru-baru ini menarik perhatian dunia pada pertengahan tahun 2016 karena adanya explosive pandemic di berbagai negara, termasuk di Indonesia. Penelitian telah menemukan bukti bahwa Zika dapat berhubungan dengan cacat kelahiran dan kondisi syaraf seperti microcephaly dan sindrom Guillain-Barre pada orang dewasa. Kata kunci: Zika virus, flavivirus, microcephaly, Guillain-Barre Syndrome

scholarly journals The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

Cell ◽  
2009 ◽  
Vol 139 (7) ◽  
pp. 1243-1254 ◽  
Author(s):  
Abraham L. Brass ◽  
I-Chueh Huang ◽  
Yair Benita ◽  
Sinu P. John ◽  
Manoj N. Krishnan ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Dengue Virus ◽  
Influenza A ◽  
H1n1 Virus ◽  
West Nile ◽  
Cellular Resistance ◽  
Influenza A H1n1 ◽  
Virus West Nile

scholarly journals Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses

mBio ◽  
2016 ◽  
Vol 7 (5) ◽  
Author(s):  
Leslie Goo ◽  
Kimberly A. Dowd ◽  
Alexander R. Y. Smith ◽  
Rebecca S. Pelc ◽  
Christina R. DeMaso ◽  
...  
Keyword(s):  
West Nile Virus ◽  
High Resolution ◽  
Dengue Virus ◽  
Zika Virus ◽  
Half Life ◽  
Alternative Mechanism ◽  
West Nile ◽  
Zikv Infection ◽  
Prolonged Incubation ◽  
The Stability

ABSTRACT Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat due in part to its association with congenital abnormalities. Other globally relevant flaviviruses include dengue virus (DENV) and West Nile virus (WNV). High-resolution structures of ZIKV reveal many similarities to DENV and suggest some differences, including an extended glycan loop (D. Sirohi, Z. Chen, L. Sun, T. Klose, T. C. Pierson, et al., 352:467–470, 2016, http://dx.doi.org/10.1126/science.aaf5316) and unique interactions among envelope (E) protein residues that were proposed to confer increased virion stability and contribute mechanistically to the distinctive pathobiology of ZIKV (V. A. Kostyuchenko, E. X. Lim, S. Zhang, G. Fibriansah, T. S. Ng, et al., Nature 533:425–428, 2016, http://dx.doi.org/10.1038/nature17994). However, in the latter study, virus stability was inferred by measuring the loss of infectivity following a short incubation period. Here, we rigorously assessed the relative stability of ZIKV, DENV, and WNV by measuring changes in infectivity following prolonged incubation at physiological temperatures. At 37°C, the half-life of ZIKV was approximately twice as long as the half-life of DENV (11.8 and 5.2 h, respectively) but shorter than that of WNV (17.7 h). Incubation at 40°C accelerated the loss of ZIKV infectivity. Increasing virion maturation efficiency modestly increased ZIKV stability, as observed previously with WNV and DENV. Finally, mutations at E residues predicted to confer increased stability to ZIKV did not affect virion half-life. Our results demonstrate that ZIKV is not uniquely stable relative to other flaviviruses, suggesting that its unique pathobiology is explained by an alternative mechanism. IMPORTANCE Zika virus (ZIKV) belongs to the Flavivirus genus, which includes other clinically relevant mosquito-borne pathogens such as dengue virus (DENV) and West Nile virus (WNV). Historically, ZIKV infection was characterized by a self-limiting, mild disease, but recent outbreaks have been associated with severe clinical complications, including Guillain-Barré syndrome and microcephaly, which are atypical of other flavivirus infections. Moreover, ZIKV has been detected in saliva, urine, and semen, and it may be sexually transmitted. Analysis of a high-resolution cryo-electron microscopic reconstruction of ZIKV hypothesized that the unusual stability of this virus contributes to its distinctive pathobiology. Here, we directly compared the stability of ZIKV to that of other flaviviruses following prolonged incubation in solution at physiological temperatures. We found that the stability of multiple ZIKV strains, including those from recent outbreaks, is intermediate between that of DENV and WNV, suggesting an alternative explanation for the unique clinical manifestations of ZIKV infection.

Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever

2018 ◽  
Vol 41 (6) ◽  
pp. e235-e243 ◽  
Author(s):  
H. Merle ◽  
A. Donnio ◽  
A. Jean-Charles ◽  
J. Guyomarch ◽  
R. Hage ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Dengue Fever ◽  
Yellow Fever ◽  
Zika Virus ◽  
West Nile ◽  
Ocular Manifestations ◽  
Virus West Nile

scholarly journals Arbovirus and seizures

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Mingrui Zheng ◽  
Shichuo Li ◽  
R. Edward Hogan ◽  
Meihua Yang
Keyword(s):  
West Nile Virus ◽  
Zika Virus ◽  
Poor Prognosis ◽  
Clinical Characteristics ◽  
Chikungunya Virus ◽  
Viral Encephalitis ◽  
High Prevalence ◽  
Virus West Nile ◽  
Vector Borne ◽  
Virus Zika

AbstractThe high prevalence and spread of arthropod-borne viruses (arboviruses) make them an important cause of viral encephalitis in humans. Most epidemic viral encephalitides have an etiology associated with arboviruses. Among various arboviruses, the Japanese encephalitis virus, West Nile virus, Zika virus, Dengue virus and Chikungunya virus can induce seizures. Arboviruses of the genus Flavivirus are usually transmitted by mosquitoes and other host animals. These vector-borne pathogens can cause epidemic viral encephalitis. Seizures may not be the major manifestation in these viral encephalitides, but may predict a poor prognosis. In this article, we discuss the relationships between these viruses and seizures from perspectives of clinical characteristics, pathogenesis, prognosis and treatments of each.

Repurposing of Potent Mtase Inhibitors Against ZIKV Utilizing Structure-Based Molecular Docking

2020 ◽  
Vol 5 (4) ◽  
pp. 53-68
Author(s):  
Sisir Nandi ◽  
Aaliya Naaz ◽  
Mridula Saxena
Keyword(s):  
West Nile Virus ◽  
Dengue Virus ◽  
Zika Virus ◽  
Viral Disease ◽  
Docking Studies ◽  
Mosquito Vector ◽  
West Nile ◽  
Methyl Transferase ◽  
Reference Drug ◽  
Virus Inhibition

Zika is an Aedes mosquito vector-borne pandemic viral disease. It is a goal for the scientists to destroy the virus completely by generating potent inhibitors. To explore the disease mechanism, various zika viral targets were explored. One of the major targets is Methyltransferase (Mtase), which is common with zika virus (ZIKV), dengue virus (DENV), and West Nile virus (WNV) belonging to the family of Flaviviridae. Therefore, an attempt has been made here to quest dengue virus and West Nile virus Mtase inhibitors, which could be repurposed on Zika virus inhibition by structure-based docking studies. The mode of interactions of 25 DENV and WNV inhibitors has been compared with natural reference drug sinefungin, which is a specific dengue virus and West Nile virus methyl transferase inhibitor. The docking results of compound numbers 4, 6, 10, 12, 13, 17, 18, and 20 exhibit the same mode of interaction with sinefungin. Therefore, these compounds could be proposed for a further experimental investigation to combat zika.

Effect of climate change on mosquito-borne pathogens.

2021 ◽  
pp. 400-404
Author(s):  
Michael Turell
Keyword(s):  
Climate Change ◽  
Global Warming ◽  
West Nile Virus ◽  
Expert Opinion ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Western Hemisphere ◽  
West Nile

Abstract This expert opinion discusses how global warming and climate change increase the risk of the introduction and severity of mosquito-borne pathogens, including West Nile virus, Chikungunya virus and Zika virus in the western hemisphere.

scholarly journals Schlafen 11 Restricts Flavivirus Replication

2019 ◽  
Vol 93 (15) ◽  
Author(s):  
Federico Valdez ◽  
Julienne Salvador ◽  
Pedro M. Palermo ◽  
Jonathon E. Mohl ◽  
Kathryn A. Hanley ◽  
...  
Keyword(s):  
Protein Folding ◽  
West Nile Virus ◽  
Dengue Virus ◽  
Zika Virus ◽  
Viral Genome ◽  
Rift Valley Fever Virus ◽  
Limiting Factor ◽  
Viral Infectivity ◽  
West Nile ◽  
Schlafen 11

ABSTRACTSchlafen 11 (Slfn11) is an interferon-stimulated gene that controls the synthesis of proteins by regulating tRNA abundance. Likely through this mechanism, Slfn11 has previously been shown to impair human immunodeficiency virus type 1 (HIV-1) infection and the expression of codon-biased open reading frames. Because replication of positive-sense single-stranded RNA [(+)ssRNA] viruses requires the immediate translation of the incoming viral genome, whereas negative-sense single-stranded RNA [(−)ssRNA] viruses carry at infection an RNA replicase that makes multiple translation-competent copies of the incoming viral genome, we reasoned that (+)ssRNA viruses will be more sensitive to the effect of Slfn11 on protein synthesis than (−)ssRNA viruses. To evaluate this hypothesis, we tested the effects of Slfn11 on the replication of a panel of ssRNA viruses in the human glioblastoma cell line A172, which naturally expresses Slfn11. Depletion of Slfn11 significantly increased the replication of (+)ssRNA viruses from theFlavivirusgenus, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV), but had no significant effect on the replication of the (−)ssRNA viruses vesicular stomatitis virus (VSV) (Rhabdoviridaefamily) and Rift Valley fever virus (RVFV) (Phenuiviridaefamily). Quantification of the ratio of genome-containing viral particles to PFU indicated that Slfn11 impairs WNV infectivity. Intriguingly, Slfn11 prevented WNV-induced downregulation of a subset of tRNAs implicated in the translation of 11.8% of the viral polyprotein. Low-abundance tRNAs might promote optimal protein folding and enhance viral infectivity, as previously reported. In summary, this study demonstrates that Slfn11 restricts flavivirus replication by impairing viral infectivity.IMPORTANCEWe provide evidence that the cellular protein Schlafen 11 (Slfn11) impairs replication of flaviviruses, including West Nile virus (WNV), dengue virus (DENV), and Zika virus (ZIKV). However, replication of single-stranded negative RNA viruses was not affected. Specifically, Slfn11 decreases the infectivity of WNV potentially by preventing virus-induced modifications of the host tRNA repertoire that could lead to enhanced viral protein folding. Furthermore, we demonstrate that Slfn11 is not the limiting factor of this novel broad antiviral pathway.

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