Evaluation of Different Serological Diagnostic Methods for Tick-Borne Encephalitis Virus: Enzyme-Linked Immunosorbent, Immunofluorescence, and Neutralization Assay

2014 ◽  
Vol 14 (2) ◽  
pp. 149-159 ◽  
Author(s):  
Nadine Litzba ◽  
Hana Zelená ◽  
Thomas R. Kreil ◽  
Bo Niklasson ◽  
Ilona Kühlmann-Rabens ◽  
...  
Keyword(s):  
Neutralization Assay ◽  
Encephalitis Virus ◽  
Diagnostic Methods ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Tick-Borne Encephalitis Virus (TBEV) Infection in Two Horses

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1775
Author(s):  
Theresa Maria Conze ◽  
Zoltán Bagó ◽  
Sandra Revilla-Fernández ◽  
Jürgen Schlegel ◽  
Lutz S. Goehring ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Epidemiological Data ◽  
Final Diagnosis ◽  
Emerging Diseases ◽  
Encephalitis Virus ◽  
Diagnostic Methods ◽  
Molecular Diagnostic ◽  
Hybridization Technique ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

A final diagnosis in a horse with clinical signs of encephalopathy can be challenging despite the use of extensive diagnostics. Clinical signs are often not pathognomonic and need to be interpreted in combination with (specific) laboratory results and epidemiological data of the geographical region of the origin of the case(s). Here we describe the diagnostic pathway of tick-borne encephalitis virus infection in two horses using established molecular diagnostic methods and a novel in situ hybridization technique to differentiate between regionally important/emerging diseases for central Europe: (i) hepatoencephalopathy, (ii) Borna disease virus, and (iii) West Nile virus infections.

TBE in South Korea

2019 ◽  
Author(s):  
Joon Young Song
Keyword(s):  
South Korea ◽  
Human Case ◽  
Encephalitis Virus ◽  
Surveillance Studies ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

Although no human case of tick-borne encephalitis (TBE) has been documented in South Korea to date, surveillance studies have been conducted to evaluate the prevalence of tick-borne encephalitis virus (TBEV) in wild ticks.

TBE in Slovakia

2019 ◽  
Author(s):  
Jana Kerlik
Keyword(s):  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

The former Czechoslovak Republic was one of the first countries in Europe where the tick-borne encephalitis virus (TBEV) was identified.

Knowledge and vaccination practices among family physicians in northeastern France regarding tick-borne encephalitis virus.

2021 ◽  
pp. 101774
Author(s):  
Marie Dollat ◽  
Anne-Pauline Bellanger ◽  
Laurence Millon ◽  
Catherine Chirouze ◽  
Quentin Lepiller ◽  
...  
Keyword(s):  
Family Physicians ◽  
Encephalitis Virus ◽  
Tick Borne Encephalitis ◽  
Northeastern France ◽  
Tick Borne Encephalitis Virus

scholarly journals Computational and Rational Design of Single-Chain Antibody against Tick-Borne Encephalitis Virus for Modifying Its Specificity

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1494
Author(s):  
Ivan K. Baykov ◽  
Pavel Y. Desyukevich ◽  
Ekaterina E. Mikhaylova ◽  
Olga M. Kurchenko ◽  
Nina V. Tikunova
Keyword(s):  
Rational Design ◽  
Fold Increase ◽  
Encephalitis Virus ◽  
Chimeric Antibody ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Glycoprotein E ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern

Tick-borne encephalitis virus (TBEV) causes 5−7 thousand cases of human meningitis and encephalitis annually. The neutralizing and protective antibody ch14D5 is a potential therapeutic agent. This antibody exhibits a high affinity for binding with the D3 domain of the glycoprotein E of the Far Eastern subtype of the virus, but a lower affinity for the D3 domains of the Siberian and European subtypes. In this study, a 2.2-fold increase in the affinity of single-chain antibody sc14D5 to D3 proteins of the Siberian and European subtypes of the virus was achieved using rational design and computational modeling. This improvement can be further enhanced in the case of the bivalent binding of the full-length chimeric antibody containing the identified mutation.

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