Persistence of Anti-West Nile Virus-Specific Antibodies Among Asymptomatic Blood Donors in Northeastern Italy

2013 ◽  
Vol 13 (12) ◽  
pp. 892-893 ◽  
Author(s):  
Anna Pierro ◽  
Paolo Gaibani ◽  
Claudia Manisera ◽  
Giada Rossini ◽  
Alba Carola Finarelli ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
West Nile ◽  
Specific Antibodies ◽  
Northeastern Italy

Seroprevalence of West Nile Virus–Specific Antibodies in a Cohort of Blood Donors in Northeastern Italy

2011 ◽  
Vol 11 (12) ◽  
pp. 1605-1607 ◽  
Author(s):  
Anna Pierro ◽  
Paolo Gaibani ◽  
Claudia Manisera ◽  
Giorgio Dirani ◽  
Giada Rossini ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
West Nile ◽  
Specific Antibodies ◽  
Northeastern Italy

scholarly journals Persistence of West Nile Virus-Specific Antibodies in Viremic Blood Donors

2007 ◽  
Vol 14 (9) ◽  
pp. 1228-1230 ◽  
Author(s):  
Harry E. Prince ◽  
Leslie H. Tobler ◽  
Cindy Yeh ◽  
Nelly Gefter ◽  
Brian Custer ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Immunoglobulin M ◽  
Plasma Samples ◽  
West Nile ◽  
Specific Antibodies ◽  
Antibody Persistence

ABSTRACT We evaluated West Nile virus (WNV) antibody persistence by using follow-up plasma samples from 35 blood donors who made viremic donations in 2005. At 26 to 34 days of follow-up, all of the donors (n = 33) were positive for WNV immunoglobulin M (IgM), IgA, and IgG. At 1-year of follow-up, 17% of the donors (n = 23) were positive for WNV IgM, 57% were positive for WNV IgA, and 100% were positive for WNV IgG.

scholarly journals Geographic Factors Contributing to a High Seroprevalence of West Nile Virus-Specific Antibodies in Humans following an Epidemic

2006 ◽  
Vol 13 (3) ◽  
pp. 314-318 ◽  
Author(s):  
Beth K. Schweitzer ◽  
Wayne L. Kramer ◽  
Anthony R. Sambol ◽  
Jane L. Meza ◽  
Steven H. Hinrichs ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
The State ◽  
Eastern Region ◽  
Seroprevalence Rate ◽  
High Seroprevalence ◽  
West Nile ◽  
Geographic Factors ◽  
Specific Antibodies ◽  
High Prevalence

ABSTRACT Sera of 624 blood donors were evaluated to determine seroprevalence of West Nile virus (WNV) antibodies following the 2003 WNV epidemic in Nebraska. Geographic factors contributing to differences in WNV seropositivity were evaluated. The overall prevalence of WNV in Nebraska was higher than reported previously in other U.S. locations (9.5% WNV immunoglobulin G seroprevalence rate), with the highest prevalence identified in the western part of the state (19.7%), followed by the central (13.8%) and the eastern (4.2%) parts. Regions of the state with the highest WNV-positive mosquito rates correlated with the highest human WNV seroprevalence rates. The results showed that both the western and central parts of the state, where mosquito positivity rates were highest, had significantly higher seroprevalence rates than the eastern region. Additional studies are needed to determine whether the high prevalence rates in Nebraska will be reflected in other states and what impact environmental and geographical factors may have on future outbreaks of WNV infection.

scholarly journals Increase in human West Nile and Usutu virus infections, Austria, 2018

2018 ◽  
Vol 23 (43) ◽  
Author(s):  
Stephan W. Aberle ◽  
Jolanta Kolodziejek ◽  
Christof Jungbauer ◽  
Karin Stiasny ◽  
Judith H. Aberle ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Blood Donation ◽  
Virus Infections ◽  
West Nile Fever ◽  
West Nile ◽  
Usutu Virus ◽  
Neuroinvasive Disease ◽  
Human West Nile Virus ◽  
Imported Cases

Between 28 June and 17 September 2018, 27 cases of human West Nile virus infections were recorded in Austria; four cases of West Nile neuroinvasive disease, 11 cases of West Nile fever, six infections detected by blood donation screening and six imported cases. In addition, 18 cases of human Usutu virus infections (all blood donors) were recorded. This is the highest number of annual infections recorded in Austria since the introduction of both viruses.

The Informed Consent Process in Whole Blood Donation

2008 ◽  
Vol 132 (6) ◽  
pp. 947-951 ◽  
Author(s):  
Lindsay A. Alaishuski ◽  
Rodney D. Grim ◽  
Ronald E. Domen
Keyword(s):  
West Nile Virus ◽  
Informed Consent ◽  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Informed Consent Process ◽  
Positive Test ◽  
Consent Process ◽  
West Nile ◽  
Eligibility Requirements

Abstract Context.—Informed consent in transfusion medicine has been an area lacking of significant research and it is unknown if donors fully comprehend the risks associated with whole blood donation. Objective.—To assess the adequacy of the informed consent process in whole blood donation. Design.—A brief questionnaire was constructed and distributed to whole blood donors visiting various fixed and mobile donor sites of the Central Pennsylvania Blood Bank. Questions consisted of demographic information; donor opinions of information content, length, and comprehension; and a short quiz pertaining to donor risks and eligibility. Results.—Analysis of 849 surveys demonstrated that donors comprehended a mean of 73.5% of the various donor eligibility and risks that were surveyed. Female and younger donors scored statistically higher on comprehension questions compared with male and older counterparts. Donors were most aware of (1) donor eligibility requirements related to acquired immunodeficiency syndrome comprehension, (2) the risk of dizziness postdonation, and (3) having lived in a certain country (93.7%–95.6% comprehension, respectively). Donors were least aware of (1) the risk of a possible referral to a physician for outstanding medical conditions or positive test results, (2) the risk of a positive test result, and (3) West Nile virus testing information (22.4%–49.3% comprehension, respectively). Conclusions.—Whole blood donors believed that they were giving informed consent, but a significant percentage of donors were unaware of several of the risks associated with blood donation, including participation in West Nile virus research testing. Our data suggest that donors do not fully comprehend the risks of whole blood donation and that repetition of information to the donor, and in multiple formats, strengthens the level of comprehension and thus the informed consent process.

scholarly journals Human West Nile Virus Lineage 2 Infection: Epidemiological, Clinical, and Virological Findings

Viruses ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 458 ◽  
Author(s):  
Monia Pacenti ◽  
Alessandro Sinigaglia ◽  
Elisa Franchin ◽  
Silvana Pagni ◽  
Enrico Lavezzo ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Blood Donors ◽  
Case Fatality ◽  
West Nile ◽  
Neuroinvasive Disease ◽  
Human West Nile Virus ◽  
Large Outbreak ◽  
Study Population ◽  
Lineage 2

West Nile virus (WNV) lineage 2 is expanding and causing large outbreaks in Europe. In this study, we analyzed the epidemiological, clinical, and virological features of WNV lineage 2 infection during the large outbreak that occurred in northern Italy in 2018. The study population included 86 patients with neuroinvasive disease (WNND), 307 with fever (WNF), and 34 blood donors. Phylogenetic analysis of WNV full genome sequences from patients’ samples showed that the virus belonged to the widespread central/southern European clade of WNV lineage 2 and was circulating in the area at least since 2014. The incidence of WNND and WNF progressively increased with age and was higher in males than in females. Among WNND patients, the case fatality rate was 22%. About 70% of blood donors reported symptoms during follow-up. Within the first week after symptom onset, WNV RNA was detectable in the blood or urine of 80% of patients, while 20% and 40% of WNND and WNF patients, respectively, were WNV IgM-seronegative. In CSF samples of WNND patients, WNV RNA was typically detectable when WNV IgM antibodies were absent. Blunted or no WNV IgM response and high WNV IgG levels were observed in seven patients with previous flavivirus immunity.

West Nile virus infection in blood donors in the New York City area during the 2010 seasonal epidemic

Transfusion ◽  
2012 ◽  
Vol 52 (12) ◽  
pp. 2664-2670 ◽  
Author(s):  
Richard O. Francis ◽  
Donna Strauss ◽  
Joan Dunn Williams ◽  
Shavonne Whaley ◽  
Beth H. Shaz
Keyword(s):  
New York ◽  
New York City ◽  
West Nile Virus ◽  
Virus Infection ◽  
York City ◽  
Blood Donors ◽  
West Nile Virus Infection ◽  
West Nile ◽  
City Area ◽  
Seasonal Epidemic
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