Vector Competence of Australian Mosquitoes for Chikungunya Virus

2010 ◽  
Vol 10 (5) ◽  
pp. 489-495 ◽  
Author(s):  
Andrew F. van den Hurk ◽  
Sonja Hall-Mendelin ◽  
Alyssa T. Pyke ◽  
Greg A. Smith ◽  
John S. Mackenzie
Keyword(s):  
Chikungunya Virus ◽  
Vector Competence

scholarly journals Vector competence of Aedes bromeliae and Aedes vitattus mosquito populations from Kenya for chikungunya virus

2018 ◽  
Vol 12 (10) ◽  
pp. e0006746 ◽  
Author(s):  
Francis Mulwa ◽  
Joel Lutomiah ◽  
Edith Chepkorir ◽  
Samwel Okello ◽  
Fredrick Eyase ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Vector Competence

scholarly journals Sequential Infection of Aedes aegypti Mosquitoes with Chikungunya Virus and Zika Virus Enhances Early Zika Virus Transmission

Insects ◽  
2018 ◽  
Vol 9 (4) ◽  
pp. 177 ◽  
Author(s):  
Tereza Magalhaes ◽  
Alexis Robison ◽  
Michael Young ◽  
William Black ◽  
Brian Foy ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Blood Meal ◽  
Zika Virus ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Vector ◽  
Molecular Aspects ◽  
Virus Interactions ◽  
Sequential Infection

In urban settings, chikungunya, Zika, and dengue viruses are transmitted by Aedes aegypti mosquitoes. Since these viruses co-circulate in several regions, coinfection in humans and vectors may occur, and human coinfections have been frequently reported. Yet, little is known about the molecular aspects of virus interactions within hosts and how they contribute to arbovirus transmission dynamics. We have previously shown that Aedes aegypti exposed to chikungunya and Zika viruses in the same blood meal can become coinfected and transmit both viruses simultaneously. However, mosquitoes may also become coinfected by multiple, sequential feeds on single infected hosts. Therefore, we tested whether sequential infection with chikungunya and Zika viruses impacts mosquito vector competence. We exposed Ae. aegypti mosquitoes first to one virus and 7 days later to the other virus and compared infection, dissemination, and transmission rates between sequentially and single infected groups. We found that coinfection rates were high after sequential exposure and that mosquitoes were able to co-transmit both viruses. Surprisingly, chikungunya virus coinfection enhanced Zika virus transmission 7 days after the second blood meal. Our data demonstrate heterologous arbovirus synergism within mosquitoes, by unknown mechanisms, leading to enhancement of transmission under certain conditions.

scholarly journals Spread, circulation and predominance of chikungunya virus East/Central/South African genotype in Northeast and Southeast Brazil

2018 ◽  
Author(s):  
André R R Freitas ◽  
Robert Paulino-Ramírez ◽  
Rodrigo N Angerami ◽  
Pedro Mª Alarcón-Elbal
Keyword(s):  
South African ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Temperate Climate ◽  
Southeastern Brazil ◽  
East Central ◽  
Diapausing Eggs ◽  
Cold Tolerant ◽  
Asian Lineage ◽  
Central South

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed in Caribbean, identified the Asian as the circulating lineage of the chikungunya. However, da Charlys da Costa et al. and Cunha et al. reported the exclusive occurrence of ECSA in two different Brazilian regions: Northeast as well as in Rio de Janeiro State (Charlys da Costa et al. 2017, Cunha et al. 2017) , suggesting that the ECSA is the predominant lineage in highly populated Brazilian areas. Despite the well-described vector competence of Aedes mosquitoes for CHIKV transmission, Aedes(Stegomyia)albopictus seems to have a greater competence for transmission of ECSA lineage compared to the Asian lineage (Vega-Rúa et al. 2015) , particularly when variable temperatures mimicking daily fluctuations of temperate climate (Vega-Rúa et al. 2015) . This statement is consistent with the fact that A albopictus has not been denounced as a vector of large outbreaks of chikungunya caused by the Asian genotype. This invasive species have capability of cold-tolerant diapausing eggs, it is paramount to establishment in temperate areas (Mitchell 1995) and new regions are invaded each year (Kraemer et al. 2015) . The predominance of the ECSA lineage in Brazil represents a potential risk of CHIKV dispersion to areas where Ae. albopictus has a broader distribution, particularly in temperate climates, including United States and Europe (Kraemer et al. 2015) , territories with intense commercial and touristic relationship with Brazil. Furthermore, the predominance of ECSA in Brazil can contributes to a better comprehension of the current distinct epidemiological scenarios between Caribbean - where explosive epidemics occurred with Aedes(Stegomyia) aegypti and Asian lineage predominated - and Brazil - with an apparent slower dispersion of CHIKV, where Ae.aegypti predominate but ECSA was prevalent linage. Both studies highlighted the importance of virological surveillance for analysis of current epidemiological scenarios and prediction of potential patterns of spreading of arboviral diseases, locally and worldwide.

scholarly journals Spread, circulation and predominance of chikungunya virus East/Central/South African genotype in Northeast and Southeast Brazil

2018 ◽  
Author(s):  
André R R Freitas ◽  
Robert Paulino-Ramírez ◽  
Rodrigo N Angerami ◽  
Pedro Mª Alarcón-Elbal
Keyword(s):  
South African ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Temperate Climate ◽  
Southeastern Brazil ◽  
East Central ◽  
Diapausing Eggs ◽  
Cold Tolerant ◽  
Asian Lineage ◽  
Central South

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed in Caribbean, identified the Asian as the circulating lineage of the chikungunya. However, da Charlys da Costa et al. and Cunha et al. reported the exclusive occurrence of ECSA in two different Brazilian regions: Northeast as well as in Rio de Janeiro State (Charlys da Costa et al. 2017, Cunha et al. 2017) , suggesting that the ECSA is the predominant lineage in highly populated Brazilian areas. Despite the well-described vector competence of Aedes mosquitoes for CHIKV transmission, Aedes(Stegomyia)albopictus seems to have a greater competence for transmission of ECSA lineage compared to the Asian lineage (Vega-Rúa et al. 2015) , particularly when variable temperatures mimicking daily fluctuations of temperate climate (Vega-Rúa et al. 2015) . This statement is consistent with the fact that A albopictus has not been denounced as a vector of large outbreaks of chikungunya caused by the Asian genotype. This invasive species have capability of cold-tolerant diapausing eggs, it is paramount to establishment in temperate areas (Mitchell 1995) and new regions are invaded each year (Kraemer et al. 2015) . The predominance of the ECSA lineage in Brazil represents a potential risk of CHIKV dispersion to areas where Ae. albopictus has a broader distribution, particularly in temperate climates, including United States and Europe (Kraemer et al. 2015) , territories with intense commercial and touristic relationship with Brazil. Furthermore, the predominance of ECSA in Brazil can contributes to a better comprehension of the current distinct epidemiological scenarios between Caribbean - where explosive epidemics occurred with Aedes(Stegomyia) aegypti and Asian lineage predominated - and Brazil - with an apparent slower dispersion of CHIKV, where Ae.aegypti predominate but ECSA was prevalent linage. Both studies highlighted the importance of virological surveillance for analysis of current epidemiological scenarios and prediction of potential patterns of spreading of arboviral diseases, locally and worldwide.

Understanding the mechanism of Chikungunya virus vector competence in three species of mosquitoes

2019 ◽  
Vol 33 (3) ◽  
pp. 375-387
Author(s):  
A. Ghosh ◽  
T. Mullapudi ◽  
S. Bomanna ◽  
B. K. Tyagi ◽  
V. Ravi ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Vector

scholarly journals Vector competence of Aedes aegypti in transmitting Chikungunya virus: effects and implications of extrinsic incubation temperature on dissemination and infection rates

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Sophiah Mbaika ◽  
Joel Lutomiah ◽  
Edith Chepkorir ◽  
Francis Mulwa ◽  
Christopher Khayeka-Wandabwa ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Chikungunya Virus ◽  
Incubation Temperature ◽  
Vector Competence ◽  
Infection Rates

scholarly journals Three-way interactions between mosquito population, viral strain and temperature underlying chikungunya virus transmission potential

2014 ◽  
Vol 281 (1792) ◽  
pp. 20141078 ◽  
Author(s):  
Karima Zouache ◽  
Albin Fontaine ◽  
Anubis Vega-Rua ◽  
Laurence Mousson ◽  
Jean-Michel Thiberge ◽  
...  
Keyword(s):  
Chikungunya Virus ◽  
Environmental Variability ◽  
Vector Competence ◽  
Virus Transmission ◽  
Mosquito Population ◽  
Mosquito Vector ◽  
Human Pathogens ◽  
Public Health Importance ◽  
Transmission Potential ◽  
Vector Borne Diseases

Interactions between pathogens and their insect vectors in nature are under the control of both genetic and non-genetic factors, yet most studies on mosquito vector competence for human pathogens are conducted in laboratory systems that do not consider genetic and/or environmental variability. Evaluating the risk of emergence of arthropod-borne viruses (arboviruses) of public health importance such as chikungunya virus (CHIKV) requires a more realistic appraisal of genetic and environmental contributions to vector competence. In particular, sources of variation do not necessarily act independently and may combine in the form of interactions. Here, we measured CHIKV transmission potential by the mosquito Aedes albopictus in all combinations of six worldwide vector populations, two virus strains and two ambient temperatures (20°C and 28°C). Overall, CHIKV transmission potential by Ae. albopictus strongly depended on the three-way combination of mosquito population, virus strain and temperature. Such genotype-by-genotype-by-environment (G × G × E) interactions question the relevance of vector competence studies conducted with a simpler set of conditions. Our results highlight the need to account for the complex interplay between vectors, pathogens and environmental factors to accurately assess the potential of vector-borne diseases to emerge.

scholarly journals Experimental risk assessment for chikungunya virus transmission based on vector competence, distribution and temperature suitability in Europe, 2018

2018 ◽  
Vol 23 (29) ◽  
Author(s):  
Anna Heitmann ◽  
Stephanie Jansen ◽  
Renke Lühken ◽  
Michelle Helms ◽  
Björn Pluskota ◽  
...  
Keyword(s):  
Central Europe ◽  
Chikungunya Virus ◽  
Vector Competence ◽  
Virus Transmission ◽  
Control Measures ◽  
Italian Population ◽  
Entomological Surveillance ◽  
Spatial Risk ◽  
Mosquito Saliva ◽  
Vector Distribution

Background Over the last decade, the abundant distribution of the Asian tiger mosquito Aedes albopictus in southern Europe and the import of chikungunya virus (CHIKV) by infected travellers has resulted in at least five local outbreaks of chikungunya fever in France and Italy. Considering the ongoing spread of Ae. albopictus to central Europe, we performed an analysis of the Europe-wide spatial risk of CHIKV transmission under different temperature conditions. Methods: Ae. albopictus specimens from Germany and Italy were orally infected with CHIKV from an outbreak in France and kept for two weeks at 18 °C, 21 °C or 24 °C. A salivation assay was conducted to detect infectious CHIKV. Results: Analyses of mosquito saliva for infectious virus particles demonstrated transmission rates (TRs) of > 35%. Highest TRs of 50% for the mosquito population from Germany were detected at 18 °C, while the Italian population had highest TRs of 63% at 18 °C and 21 °C, respectively. Temperature data indicated a potential risk of CHIKV transmission for extended durations, i.e. sufficiently long time periods allowing extrinsic incubation of the virus. This was shown for areas already colonised by Ae. albopictus, as well as for large parts of central Europe that are not colonised. Conclusion: The current risk of CHIKV transmission in Europe is not primarily restricted by temperature, which allows extrinsic incubation of the virus, but rather by the vector distribution. Accordingly, all European countries with established populations of Ae. albopictus should implement respective entomological surveillance and monitoring systems, as basis for suitable control measures.

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